Shahid Beheshti University Journal of Sport and Exercise Physiology 2676-3710 13 2 2021 02 19 Effect of endurance training with two different intensities on serum levels of adipolin and some of its regulating factors in sedentary men Effect of endurance training with two different intensities on serum levels of adipolin and some of its regulating factors in sedentary men 45 56 100866 10.52547/joeppa.13.2.45 FA Rahman Soori Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran Mohammadreza Asad Department of physical education and sport Sciences, Payame Noor University, Tehran, Iran Zohreh Barahoiejamar Department of Sports Physiology, Payame Noor University, Tehran, Iran Najmeh Rezaian Department of physical education and sport Sciences, Bonjourd Branch, Islamic Azad University, Bojnourd, Iran Journal Article 2015 09 12 <strong>Purpose</strong>: Adipolin is a novel anti-inflammatory adipokine with insulin-sensitizing effects that ameliorates glucose intolerance and insulin resistance. Since physical activity and exercise are one of the effective and safe therapeutic interventions in improving insulin resistance; this study investigated effect of endurance training of two different intensities on adipolin and furin levels and insulin resistance index (HOMA-IR) in sedentary men. <br /><strong>Methods</strong>: 38 sedentary overweight men (BMI>25 Kg/m², aged 35-50 years) randomly assigned in to two training groups of low (n=13) and high intensity (n=12) and control (n=13) groups. Subjects in moderate intensity training group run on treadmill at intensity of 50-70 % of maximal heart rate and high intensity training group run at 70-90% of maximal heart rate, 30-45 minutes per session and three sessions per week for 10 weeks. Serum levels of adipolin, furin, insulin and fasting glucose and anthropometric indices measured before and 48 hours after last training session. Statistical analysis was done by one-way ANOVA and p < 0.05 considered significant. <br /><strong>Results</strong>: changes in adipolin levels were significantly different between group of moderate intensity training and high intensity training one. Moreover, there were significant differences between two groups of moderate and high intensity training and control group for changes in weight, body mass index, body fat percentage and waist to hip ratio. <br /><strong>Conclusion</strong>: it seems that intensity of endurance training in addition to effecting anthropometric indices, is the important factor to determine changes of adipolin levels in sedentary overweight men; however, it seems more studies are necessary to identify the mediated mechanism. <strong>Purpose</strong>: Adipolin is a novel anti-inflammatory adipokine with insulin-sensitizing effects that ameliorates glucose intolerance and insulin resistance. Since physical activity and exercise are one of the effective and safe therapeutic interventions in improving insulin resistance; this study investigated effect of endurance training of two different intensities on adipolin and furin levels and insulin resistance index (HOMA-IR) in sedentary men. <br /><strong>Methods</strong>: 38 sedentary overweight men (BMI>25 Kg/m², aged 35-50 years) randomly assigned in to two training groups of low (n=13) and high intensity (n=12) and control (n=13) groups. Subjects in moderate intensity training group run on treadmill at intensity of 50-70 % of maximal heart rate and high intensity training group run at 70-90% of maximal heart rate, 30-45 minutes per session and three sessions per week for 10 weeks. Serum levels of adipolin, furin, insulin and fasting glucose and anthropometric indices measured before and 48 hours after last training session. Statistical analysis was done by one-way ANOVA and p < 0.05 considered significant. <br /><strong>Results</strong>: changes in adipolin levels were significantly different between group of moderate intensity training and high intensity training one. Moreover, there were significant differences between two groups of moderate and high intensity training and control group for changes in weight, body mass index, body fat percentage and waist to hip ratio. <br /><strong>Conclusion</strong>: it seems that intensity of endurance training in addition to effecting anthropometric indices, is the important factor to determine changes of adipolin levels in sedentary overweight men; however, it seems more studies are necessary to identify the mediated mechanism. https://joeppa.sbu.ac.ir/article_100866_a0723260f5448fce85d3d36f3247b7ee.pdf