Shahid Beheshti University Journal of Sport and Exercise Physiology 2676-3710 4 1 2011 04 21 The effect of endurance training and curcumin supplement on lung HIF- α1 levels in rat exposed to lead acetate The effect of endurance training and curcumin supplement on lung HIF- α1 levels in rat exposed to lead acetate 98598 10.48308/joeppa.2011.98598 FA Journal Article 2015 05 17 Background and purpose: Hypoxia inducible factor-1α (HIF- α1) as a key regulator of molecular responses to hypoxia is regarded as a mediator for a large scope of cellular and physiological mechanisms necessary for compatibility with decrease of oxygen. The aim of present research was to study the effet of endurance training, curcumin supplement and lead on the lung HIF- α1 levels.Methods: Sixty 50-day- old male wistar rat are divided to two control groups, two exercise groups (exercise + lead and exercise + lead + supplement) and two groups without exercise (curcumine + lead and lead). The exercise includes running with speed of 15 to 22 meter per minute on the animal treadmill without slope for 25 to 64 minutes for eight weeks. After the eight weeks of exercise and seventy-two hours after the last exercise the rat are killed and the intended tissues are used for measuring HIF- α1 using kit and ELISA method. Kolmograph Smirnov test and LSD test in the level P < 0.05 are used to analyze the findings of the research. Results: The results of the research indicate intra peritoneum injection of lead increase the amount of lead in the lead group. A significant increase in the level of HIF- α1 in lung is seen in the control group in contrast to lead group and exercise + lead + supplement group and in vehicle group in contrast to exercise + lead + supplement group and in lead + supplement group in contrast to exercise + lead + supplement group. A significant decrease in the level of HIF- α1 in lung is seen in lead group in contrast to exercise + lead group and in exercise + lead + supplement group in contrast to exercise + lead group. The results of the research indicate intra-peritoneum injection of lead increase the amount of lead in the lead group. A significant decrease in the level of HIF- α1 in liver is seen only in lead group in contrast to exercise + lead + supplement group and lead group. Conclusion: The results of this research indicate regular endurance exercise can counteract the effects of stat lead and it can be regarded as a useful solution for pollution caused by lead. Also according to previous research the presence curcumin in of the train and lead, are expected to reduce and inhibit HIF- α1 but there was no such thing, in lung tissue combined exercise, curcumin, lead, HIF- α1 is increased because it can be attributed to the dose. Background and purpose: Hypoxia inducible factor-1α (HIF- α1) as a key regulator of molecular responses to hypoxia is regarded as a mediator for a large scope of cellular and physiological mechanisms necessary for compatibility with decrease of oxygen. The aim of present research was to study the effet of endurance training, curcumin supplement and lead on the lung HIF- α1 levels.Methods: Sixty 50-day- old male wistar rat are divided to two control groups, two exercise groups (exercise + lead and exercise + lead + supplement) and two groups without exercise (curcumine + lead and lead). The exercise includes running with speed of 15 to 22 meter per minute on the animal treadmill without slope for 25 to 64 minutes for eight weeks. After the eight weeks of exercise and seventy-two hours after the last exercise the rat are killed and the intended tissues are used for measuring HIF- α1 using kit and ELISA method. Kolmograph Smirnov test and LSD test in the level P < 0.05 are used to analyze the findings of the research. Results: The results of the research indicate intra peritoneum injection of lead increase the amount of lead in the lead group. A significant increase in the level of HIF- α1 in lung is seen in the control group in contrast to lead group and exercise + lead + supplement group and in vehicle group in contrast to exercise + lead + supplement group and in lead + supplement group in contrast to exercise + lead + supplement group. A significant decrease in the level of HIF- α1 in lung is seen in lead group in contrast to exercise + lead group and in exercise + lead + supplement group in contrast to exercise + lead group. The results of the research indicate intra-peritoneum injection of lead increase the amount of lead in the lead group. A significant decrease in the level of HIF- α1 in liver is seen only in lead group in contrast to exercise + lead + supplement group and lead group. Conclusion: The results of this research indicate regular endurance exercise can counteract the effects of stat lead and it can be regarded as a useful solution for pollution caused by lead. Also according to previous research the presence curcumin in of the train and lead, are expected to reduce and inhibit HIF- α1 but there was no such thing, in lung tissue combined exercise, curcumin, lead, HIF- α1 is increased because it can be attributed to the dose.

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