Shahid Beheshti University Journal of Sport and Exercise Physiology 2676-3710 4 1 2011 04 21 The effects of short-term creatine monohydrate supplementation on a single resistance exercise induced-indirect indicators some of cellular damage in male wrestler The effects of short-term creatine monohydrate supplementation on a single resistance exercise induced-indirect indicators some of cellular damage in male wrestler 98612 10.48308/joeppa.2011.98612 FA Journal Article 2015 05 17 <br /><br />Purpose: Creatine monohydrate as one of the most widely consumed nutritional supplements to increase<br />athletic performance is widely popular among athletes. However, there are recent concerns about some of<br />the adverse effects of short and long term use of creatine on health indices. Therefore this study was<br />conducted to identify the effect of creatine monohydrate loading on total serum cellular damage indices<br />changes (Creatine Kinase & Lactate Dehydrogenase) following one session resistance exercise in male<br />wrestler. Methods: Eighteen volunteer collegiate young male wrestlers (aged 21.11±1.13 years, fat<br />12.67±1.84 %, and BMI 21.96±0.70 kg/m2) in a quasi-experimental, randomized and double-blind design<br />were allocated equally into supplement and placebo groups. After six consecutive days supplementation<br />(300 mg.kg-1.day body weight creatine monohydrate or dextrose), all subjects were participated in a<br />single- session circle resistance exercise protocol (with 80 % 1-RM in 3 sets with 6 repetition) include six<br />station participated. Changes in cellular damage indices were determined in three phases (before and after<br />the supplement phase, 24 hours after the exercise protocol). Data were analyzed by repeated measure<br />ANOVA, Bonferroni and independent t test at α≤0.05. Results: The results show that the creatine loading<br />has only significant effect on the basal total serum CK in supplement group (P<0.05). Moreover, the total<br />serum CK and LDH in both groups (supplement & placebo) were significantly increased 24 hour after the<br />resistance exercise (P<0.05). However, the change range of the cellular damage indices 24 hours in<br />supplement group was insignificantly lower than in placebo group (P>0.05).Conclusion: According to<br />normal variation of total serum Creatine Kinase in the base case and due to the lack of effect of creatine<br />on 24 hours indicators of cellular damage in male wrestler after the resistance exercise, definitive<br />comment in related creatine supplementation induced- cellular damage, more research is needed in the<br />further.<br /><br /><br /> <br /><br />Purpose: Creatine monohydrate as one of the most widely consumed nutritional supplements to increase<br />athletic performance is widely popular among athletes. However, there are recent concerns about some of<br />the adverse effects of short and long term use of creatine on health indices. Therefore this study was<br />conducted to identify the effect of creatine monohydrate loading on total serum cellular damage indices<br />changes (Creatine Kinase & Lactate Dehydrogenase) following one session resistance exercise in male<br />wrestler. Methods: Eighteen volunteer collegiate young male wrestlers (aged 21.11±1.13 years, fat<br />12.67±1.84 %, and BMI 21.96±0.70 kg/m2) in a quasi-experimental, randomized and double-blind design<br />were allocated equally into supplement and placebo groups. After six consecutive days supplementation<br />(300 mg.kg-1.day body weight creatine monohydrate or dextrose), all subjects were participated in a<br />single- session circle resistance exercise protocol (with 80 % 1-RM in 3 sets with 6 repetition) include six<br />station participated. Changes in cellular damage indices were determined in three phases (before and after<br />the supplement phase, 24 hours after the exercise protocol). Data were analyzed by repeated measure<br />ANOVA, Bonferroni and independent t test at α≤0.05. Results: The results show that the creatine loading<br />has only significant effect on the basal total serum CK in supplement group (P<0.05). Moreover, the total<br />serum CK and LDH in both groups (supplement & placebo) were significantly increased 24 hour after the<br />resistance exercise (P<0.05). However, the change range of the cellular damage indices 24 hours in<br />supplement group was insignificantly lower than in placebo group (P>0.05).Conclusion: According to<br />normal variation of total serum Creatine Kinase in the base case and due to the lack of effect of creatine<br />on 24 hours indicators of cellular damage in male wrestler after the resistance exercise, definitive<br />comment in related creatine supplementation induced- cellular damage, more research is needed in the<br />further.<br /><br /><br /> https://joeppa.sbu.ac.ir/article_98612_689a985e9ab6cd6d6989c08a1dfcdae8.pdf