Shahid Beheshti University Journal of Sport and Exercise Physiology 2676-3710 9 1 2016 05 21 Inflammatory Responses of Children with Idiopathic Short Stature to Two Weeks of Inactivity After the One Period of Physical Activity Inflammatory Responses of Children with Idiopathic Short Stature to Two Weeks of Inactivity After the One Period of Physical Activity 1325 1332 98803 10.48308/joeppa.2016.98803 FA Journal Article 2016 09 13 background and aim: physical activity is an important factor in improving the immune system and decreasing inflammatory agents, which can expand the growth by influencing anabolic and catabolic mediators. This study is being done with the purpose of determine inflammatory responses of children with idiopathic short stature to two weeks inactivity after the one period of physical activity. Materials and Methods: this semi-experimental study was conducted on the population of children attending to endocrine clinic of Atieh hospital of Tehran. 14 idiopathic short stature children (4 girls, 10 boys) were randomly divided into control and experimental groups. Experimental group performed eight weeks, three sessions each week and each session 60 minutes. The intensity of physical activity was 40-60% of HRmax. IL-6, TNF-α and IL-1β were also measured before and after eight weeks of physical activity and after two weeks inactivity. Data were analyzed by kolmogorov-smirnov, independent t test and one-way ANOVA with repeated measures. Results: The result indicate that after eight weeks of physical activity, IL-6 increased insignificantly and IL-1β decreased insignificantly(p>0.05). Also, following two weeks of inactivity after eight weeks, inflammatory cytokines TNF-α , IL-1β decrease and IL-6 increase, but this changes were not significant(p>0.05). There was a significant difference between groups in the TNF-α (P=0.005) response after two weeks of inactivity. Conclusion: It seems that some positive effects of physical activity remain even after two weeks of inactivity. Therefore, in order to determine the required time for the inflammatory cytokines to be increased, researches with workout cycles longer than eight weeks are needed. background and aim: physical activity is an important factor in improving the immune system and decreasing inflammatory agents, which can expand the growth by influencing anabolic and catabolic mediators. This study is being done with the purpose of determine inflammatory responses of children with idiopathic short stature to two weeks inactivity after the one period of physical activity. Materials and Methods: this semi-experimental study was conducted on the population of children attending to endocrine clinic of Atieh hospital of Tehran. 14 idiopathic short stature children (4 girls, 10 boys) were randomly divided into control and experimental groups. Experimental group performed eight weeks, three sessions each week and each session 60 minutes. The intensity of physical activity was 40-60% of HRmax. IL-6, TNF-α and IL-1β were also measured before and after eight weeks of physical activity and after two weeks inactivity. Data were analyzed by kolmogorov-smirnov, independent t test and one-way ANOVA with repeated measures. Results: The result indicate that after eight weeks of physical activity, IL-6 increased insignificantly and IL-1β decreased insignificantly(p>0.05). Also, following two weeks of inactivity after eight weeks, inflammatory cytokines TNF-α , IL-1β decrease and IL-6 increase, but this changes were not significant(p>0.05). There was a significant difference between groups in the TNF-α (P=0.005) response after two weeks of inactivity. Conclusion: It seems that some positive effects of physical activity remain even after two weeks of inactivity. Therefore, in order to determine the required time for the inflammatory cytokines to be increased, researches with workout cycles longer than eight weeks are needed.

https://joeppa.sbu.ac.ir/article_98803_589d5d2fa9e8bb175b760e68f93fee94.pdf