تأثیر تمرین مقاومتی دایره‌ای بر غلظت سرمی واسپین و شاخص‌ مقاومت انسولینی در بیماران مبتلا به دیابت نوع 2

نوع مقاله : علمی - پژوهشی

نویسندگان

1 داﻧﺸﮕﺎه آزاد اﺳﻼﻣﯽ واﺣﺪ ﺳﺎری

2 داﻧﺸﮕﺎه ﻣﺎزﻧﺪران

چکیده

مقدمه: مقاومت انسولینی در پاتولوژی دیابت نقش مهمی دارد. واسپین، آدیپوکین جدیدی است که در افزایش‌ حساسیت انسولین و بهبود تحمّل گلوکز نقش دارد. اطلاعات اندکی در مورد تأثیر تمرین منظم ورزشی به ویژه تمرین مقاومتی بر غلظت واسپین وجود دارد. از این‌رو هدف پژوهش حاضر بررسی تأثیر تمرین مقاومتی دایره‌ای بر غلظت پلاسمایی واسپین، شاخص‌ مقاومت انسولینی و ارتباط آن‌ها در مردان بزرگسال مبتلا به بیماری دیابت نوع 2 می‌باشد. روش‌‌ شناسی: 18 مرد بزرگسال مبتلا به دیابت نوع 2 (سن 73/7 ± 50/48 سال، وزن 60/12±41/79 کیلوگرم) به طور تصادفی به گروه‌های تجربی (تعداد 10 نفر) و کنترل (تعداد 8 نفر) تقسیم شدند. گروه تجربی در برنامه تمرین مقاومتی (3 روز در هفته، برای 8 هفته) با شدت 50 تا 80 درصد یک تکرار بیشینه شرکت کردند. نمونه‌گیری خون قبل و بعد از دوره تمرینی در حالت ناشتا 12 ساعته انجام شد و سطوح واسپین، گلوکز، انسولین و شاخص مقاومت انسولینی با روش الایزا اندازه‌گیری شدند. پس از سنجش متغیرها و تحلیل آماری با استفاده از آزمون t مشخص شد که: نتایج: پس از 8 هفته تمرین مقاومتی، سطوح گلوکز، انسولین و مقاومت به انسولین در گروه تمرین مقاومتی نسبت به گروه کنترل، به‌طور معنا‌داری کاهش یافتند (مقدار p به ترتیب برابر با 040/0، 021/0 و 011/0). در حالی‌که غلظت سرمی واسپین در گروه تمرین مقاومتی در مقایسه با گروه کنترل تغییر معناداری نشان نداد (380/0p=). هم-چنین ارتباط معناداری بین غلظت سرمی واسپین و گلوکز، انسولین و شاخص‌ مقاومت انسولینی در بین دو گروه مشاهده نشد. بحث و نتیجه‌گیری: نتایج پژوهش حاضر حاکی از آن است که تمرین مقاومتی دایره‌ای می‌تواند به عنوان یک عامل موثر در بهبود حساسیت انسولینی در بیماران دیابتی نوع 2 به‌کار گرفته شود.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of circuit resistance training on serum vaspin concentration and insulin resistance in patients with type 2 diabetes

چکیده [English]


Introduction: Insulin resistance has an important role in the pathology of diabetes. Vaspin is a novel adipokine that
has a role in increase insulin sensitivity and improve glucose tolerance. There is limited information available
regarding the effect of regular exercise, particularly resistance training on serum vaspin concentrations. The purpose
of this study was to investigate the effect of Circuit Resistance training on serum vaspin levels, Insulin resistance
and its relation In adult men with type 2 diabetes. Methods: 18 adult men with type 2 diabetes (age: 48.50±7.73 yr,
weight: 79.41±12.60 kg) were randomly assigned to experimental (n= 10) and control (n= 8) groups. Experimental
group participated in a resistance training program (3 days a week for 8 weeks) with an intensity of 50 to 80% of
one repetition maximum. Blood samples collected in the 12-hour fasting state before and after training period and
levels of vaspin, insulin, glucose and insulin resistance index (HOMA-IR) were measured by ELISA method. After
evaluating variables and statistical analysis with t- test, It was found that: Results: After a 8 week resistance
training, levels of glucose, insulin and insulin resistance index (HOMA-IR) were significantly decreased (P= 0.040,
0.012 and 0.011, respectively). Whereas, serum vaspin concentration showed no significant changes in resistance
trained group when compared with their control groups (p=0/380). Also, no significant correlation between Serum
vaspin concentration and levels of glucose, insulin and HOMA-IR were observed between the two groups.
Conclusion: The results of the present study suggest that circuit resistance training can be used as an effective factor
in improving of insulin sensitivity in type 2 diabetic patients.

کلیدواژه‌ها [English]

  • Diabetes mellitus
  • Vaspin
  • Circuit resistance training
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  • تاریخ دریافت: 27 اردیبهشت 1394
  • تاریخ بازنگری: 29 خرداد 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 اردیبهشت 1391