پاسخهای متابولیکی به هایپرگلیسمی طی فعالیت ورزشی در مردان سالمند

نوع مقاله : علمی - پژوهشی

نویسنده

دانشکده تربیت بدنی و علوم ورزشی، دانشگاه عالمه طباطبائی، تهران، ایران

چکیده

هدف: این تحقیق برای تعیین پاسخهای متابولیکی به تزریق گلوکز )هایپرگلیسمی( طی فعالیت ورزشی در مردان سالمند طراحی
شد.
روشها: هشت مرد سالم )میانگین سن 2/5±3/63 سال( داوطلبانه در این تحقیق شرکت کردند و در دو جلسه مجزا به فاصله
یک هفته به آزمایشگاه فیزیولوژی مراجعه کردند. آزمودنیها در هر جلسه 40 دقیقه فعالیت ورزشی روی دوچرخه با 60 درصد
حداکثر اکسیژن مصرفی بعد از 30 دقیقه تزریق گلوکز یا دارونما اجرا کردند. گازهای تنفسی طی فعالیت اندازهگیری شدند و 4
نمونه خونی قبل از تزریق گلوکز، بعد از اتمام 30 دقیقه تزریق گلوکز، در دقیقه 20 فعالیت، و سریعا بعد از اتمام فعالیت برای
اندازهگیری فاکتورهای متابولیکی، گرفته شدند. نمونههای خونی برای اندازهگیری انسولین، اسید چرب آزاد استریفیهنشده،
گلیسرول، بتاهیدروکسی بوتیرات (OHB-3 (و مقاومت به انسولین (HOMA (استفاده شدند. اکسیداسیون چربی و کربوهیدرات با
استفاده ار گازهای تنفسی دیاکسید کربن و اکسیژن مصرفی محاسبه شد.
نتایج: آنالیز آماری دادهها افزایش معنادار )05/P0 )انسولین و گلوکزو کاهش اسید چرب آزاد غیراستریفیه و گلیسرول را طی
فعالیت ورزشی بعد از تزریق گلوکز نشان داد اما تاثیر معناداری بر سوخت چربی و کربوهیدرات مشاهده نشد.
نتیجهگیری: بر اساس یافتههای این تحقیق میتوان نتیجهگیری کرد که در مردان سالمند حفظ سطح گلوکز خون حین فعالیت
ورزشی از طریق تزریق گلوکز بر لیپولیز و عوامل متابولیکی تاثیر دارد اما بر اکسیداسیون چربی و کربوهیدرات در عضله تاثیر ندارد.

کلیدواژه‌ها


عنوان مقاله [English]

Metabolic responses to hyperglycaemia during exercise in elderly men

نویسنده [English]

  • Minoo Bassami
Faculty of physical education and sports sciences, Allameh Tabataba'i University, Tehran, Iran
چکیده [English]

Purpose: The present study was designed to determine the metabolic responses to hyperglycaemia during
exercise in elderly men.
Methods: Eight healthy males (Age, 63.3±5.2 years) voluntarily participated and reported to the physiology
laboratory on two separate occasions. With one week intervening subjects performed 40 min exercise on a
cycle ergometer at 60% VO2max after 30 minutes of ‘prime’ glucose or placebo infusion. Respiratory gases
were undertaken throughout the exercise and four blood samples were taken before infusion, after 30 min
infusion, after 20 min exercise and immediately after exercise. Blood samples were analyzed to determine
insulin, NEFA, glycerol, 3- OHB and HOMA Scores. Fat and carbohydrate oxidation were calculated by using
respiratory gases of O2 and CO2.
Results: Insulin and glucose concentrations were significantly (p<0.05) higher, and NEFA and glycerol were
lower during exercise after glucose infusion. However, 3-OHB, fat and carbohydrate oxidations were not
significantly different between two trials (p>0.05).
Conclusions: Based on the findings of the present study it could be concluded that in elderly men the
maintenance of blood glucose during exercise through glucose infusion affects on lipolysis and metabolic
factors, but has no effect on muscular fat and carbohydrate oxidation.

کلیدواژه‌ها [English]

  • Cycling: Cycling
  • Fat oxidation
  • Carbohydrate oxidation
  • Elderly
1. Rita B, Matthew L. Johnson P, Yogish C, Kudva,
MD and Ananda B,. Exercise, Hypoglycemia,
and Type 1 Diabetes. Diabetes Technology and
Therapeutics. 2014; 16(6). 331-337
2. Jeng C, Chang S. R, Chen, and Tseng I. J. Effects
of arm exercise on serum glucose response in
type 2 DM patients. The Journal of Nursing
Research. 2002; 10 (3). 187–194.
3. Jeng C, and Huang W. H. Establishment of a
predictive model of serum glucose changes
under different exercise intensities and
durations among patients with type 2 diabetes
mellitus. The Journal of Nursing Research.
2003; 11(4). pp. 287–294.
4. Tasuku T, Alanna F, Baljot S. Chahal, G. J, Bell
L. J, McCargar, and Normand G. B. Exploring
the Variability in Acute Glycemic Responses to
Exercise in Type 2 Diabetes. Journal of
Diabetes Research. Volume 2013; 6-12
5. Bassami M, MacLaren D.P, Ahmadizad S,
Doran D. Effects of mixed isoenergetic meals
on fat and carbohydrate metabolism during
exercise in older men. Journal of Nutrition and
Metabolism. Volume 2011;10: 1-6
6. Jackson R.A. Mechanisms of age-related
glucose intolerance. Diabetes Care 1990; 13:
9- 19.
7. Steven J, Prior A. S, Ryan T. G. Stevenson, and
Andrew P. G. Metabolic inflexibility during
submaximal aerobic exercise is associated
with glucose intolerance in obese older adults
Obesity. Obesity Biology and Integrated
Physiology. 2014; 22(2): 451–457.
8. DeFronzo R.A., Tobin J.D., Andres R. Glucose
clamp technique: a method for quantifying
insulin secretion and resistance. American
Journal of Physiology 1979; 237(3):E214-23.
9. Hagberg J.M., Seals D.R., Yerg J.E., Gavin J.,
Gingerich R., Premachandra B., et al.
Metabolic responses to exercise in young and
older athletes and sedentary men. Journal of
Apply Physiology 1988; 65: 900-908.
10. Hawley J.A., Burke L.M., Angus D.J., Fallon K.E.,
Martin D.T., Febbraio M.A. Effect of altering
substrate availability on metabolism and
performance during intense exercise. British
Journal of Nutrition. 2000; 84: 829-38
11. MacLaren D.P, Mohebbi H, Nirmalan M,
Keegan M.A, Best C.T, Perera D, Haevie M.N,
et al. Effect of a 2-h hyperglycemichyperinsulinemic glucose clamp to promote
glucose storage on endurance exercise
performance. European Journal of Apply
physiology.2011; 111:2105-2114.
12. MacLaren DP, Reilly T, Campbell IT, Hopkin C.
Hormonal and metabolic responses to
maintained hyperglycemia during prolonged
exercise. Journal of Apply Physiology. 1999;
87:124-31.
13. Frayn K.N. Calculation of substrate oxidation
rates in vivo from gaseous exchange. Journal
of Apply Physiology. 1983; 55:628-34.
14. Abumrad N.N, Rabin D, Diamond M.P, Lacy
W.W. Use of a heated superficial hand vein as
an alternative site for the measurement of
amino acid concentrations and for the study of
glucose and alanine kinetics in man.
Metabolism 1981; 30: 936-40 15. Wallace, TM, Levy, JC, Matthews, D R. Use and
abuse HOMA modeling. Diabetes Care. 2004.
26(6): 1487-1495.
16. Green CJ, Campell IT, Sullivan E. Septic patients
in multiple organ failure can oxidise infused
glucose, but non-oxidative disposal (storage) is
impaired. Clinical Science. 1995; 89:601-609.
17. Sherman W.M. and Leenders N. Fat loading:
the next magic bullet? International Journal of
Sport Nutrition. 1995; 5: S1-S12
18. Fanelli C, Calderone S, Epifano L, De Vincenzo
A, Modarelli F, Pampanelli S, et al.
Demonstration of a critical role for free fatty
acids in mediating counter regulatory
stimulation of gluconeogenesis and
suppression of glucose utilization in humans.
Journal of Clinical Investigation. 1993;
92:1617-22.
19. Boden G, Chen X, Ruiz J, White J V, Rossetti L.
Mechanisms of fatty acid-induced inhibition of
glucose uptake. Journal of Clinical
Investigation.1994; 93(6):2438-46.
20. Wahren J, Hagenfeldt L, Felig P. Glucose and
free fatty acid utilization in exercise. Studies in
normal and diabetic man. Journal of Medicine
and Sciences 1975; 11(6):551-9.
21. Vukovich MD, Costill DL, Hickey MS, Trappe
SW, Cole KJ, Fink WJ. Effect of fat emulsion
infusion and fat feeding on muscle glycogen
utilization during cycle exercise. Journal of
Apply Physiology. 1993; 75:1513-8.
22. Manetta J, Brun JF, Prefaut C, Mercier J.
Substrate oxidation during exercise at
moderate and hard intensity in middle-aged
and young athletes vs sedentary men.
Metabolism. 2005; 54:1411-9.
23. Hansen BF, Asp S, Kiens B, Richter EA.
Galycogen concentration in human skeletal
muscle: effect of prolonged insulin and
glucose infusion. Scandinavian Journal of
Medicine and Science in Sports. 1999; 9: 209-
213.
24. Tasuku Terada, Alanna Friesen, Baljot S,
Chahal, Gordon J, Bell, Linda J, McCargar et al.
Exploring the Variability in acute glycemic
responses to exercise in type 2 diabetes.
Journal Diabetes Research. 2013; 10.1155
25. Romijn JA, Coyle EF, Sidossis LS, Rosenblatt J,
Wolfe RR. Substrate metabolism during
different exercise intensities in endurancetrained women. Journal of Apply Physiology.
2000; 88:1707-14.
26. Bassamin M, Ahmadizad S, Doran D, MacLaren
D.P. Effects of exercise intensity and duration
on fat metabolism in trained and untrained
older males. European Journal of Apply
physiology. 2007; 101:525-532.
27. Fink R I, Wallace P, Olefsky J M. Effects of aging
on glucose-mediated glucose disposal and
glucose transport. Journal of Clinical
Investigation. 1986; 77:2034-41.
28. Horowitz JF, Klein S. Lipid metabolism during
endurance exercise. American Journal of
Clinical Nutrition. 2000; 72:558S-63S.
29. Partha C, Joun Kim JU, Maneet S, yu-kyong Sh,
Jessica K, Kumbrink J, et al. Insulin inhibits
lipolysis in adipocytes via the evolutionarily
conserved mTORCI-Egr1- ATGL- Mediated
pathway. Molecular and Cellular Biology.
2013; 33: 18, 3659-3666 30. Sarah M C, David F T, Danielle N G, Rachael M
E, Lisa M D, Abigial S D, et al. Insulin regulates
adipocyte lipolysis via an Akt- Independent
Signaling pathway. Molecular and Cellular
Biology. 2010; 30 (21). 5009-5020.
  • تاریخ دریافت: 14 اسفند 1395
  • تاریخ بازنگری: 24 شهریور 1396
  • تاریخ پذیرش: 03 مهر 1396
  • تاریخ اولین انتشار: 01 شهریور 1397
  • تاریخ انتشار: 01 شهریور 1397