تاثیر هشت هفته تمرین پیلاتس بر سطوح سرمی آیریزین و شاخص مقاومت به انسولین زنان چاق

نوع مقاله : علمی - پژوهشی

نویسنده

دانشگاه شهید چمران اهواز

چکیده

چکیده:هدف تحقیق :آیریزین مایوکین، آدیپوکین، و نوروکین جدیدی است که اخیراً در انسان و موش کشف شده است، شواهد نشان می‌دهد آیریزین در انسان، با چاقی و دیابت ارتباط دارد، لذا پژوهش حاضر با هدف تاثیر تمرین بلند‌مدت پیلاتس بر سطح سرمی آیریزین و شاخص مقاومت به انسولین زنان چاق، انجام شده است.روش تحقیق: پژوهش حاضر از نوع نیمه­تجربی با طرح پیش آزمون- پس آزمون بود. در این تحقیق 24 زن چاق(میانگین سنی61/8±4/38 سال و میانگین BMI 95/2±6/35 کیلوگرم بر مترمربع)، به طور داوطلبانه شرکت کردند و به طور تصادفی به دو گروه تمرین پیلاتس(15 نفر) و کنترل(9 نفر) تقسیم شدند. گروه تمرین به مدت هشت هفته، سه جلسه در هفته به تمرین پیلاتس با RPE 16-14پرداختند، در حالی که گروه کنترل هیچ­گونه تمرینی نداشتند. نمونه‌های خونی قبل و بعد از تمرین اندازه‌گیری شد. برای تجزیه‌و‌تحلیل داده‌های آماری از آزمون تی­وابسته و تحلیل کواریانس استفاده شد.نتایج تحقیق: تحلیل آماری نشان داد، پس از هشت هفته تمرین پیلاتس سطوح سرمی گلوکز، انسولین، مقاومت به انسولین و آیریزین در گروه تمرین در مقایسه با گروه کنترل تغییر معناداری پیدا نکرد(05/0<P). همچنین، هیچ رابطه ای بین آیریزین با BMI، وزن، گلوکز، انسولین و شاخص مقاومت به انسولین مشاهده نشد.بحث‌ونتیجه­گیری: نتایج حاکی از این است که انجام هشت هفته تمرین پیلاتس، اثری بر سطوح گلوکز، انسولین، مقاومت به انسولین و آیریزین زنان چاق ندارد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Eight Weeks Pilates Training On Irisin Serum Levels and Insulin Resistance Index in Obese Women

چکیده [English]

Abstract
Aim: Irisin is a novel myokine, adipokine and neurokine that recently discovered in humans and mice. Evidence suggests that Irisin is associated with obesity and diabetes. The purpose of this study was to determine the effect of 8-weeks Pilates training programs on serum irisn levels and insulin resistance index in obese women.
Methods: In this quasi-experimental study, 24 obese women (mean age 38/4±8/61 years and BMI 35/6±2/95 kg/m2) volunteered to participate in this study and were randomly divided into Pilates group (n=15) and control group (n=9). Pilates training program performed in 8 weeks, 3 times per week, and 14-16 RPE. Blood samples were collected before and after training. Data were analyzed with paired-sample t-test and ANCOVA.
Results: The results indicated no significant changes in blood glucose, insulin, insulin resistance index and serum Irisin levels in Pilate’s group compared with the control group after 8 weeks (p≥0.05). Furthermore, correlation was not between Irisin to BMI, weight, glucose, insulin, and insulin resistance index (p≥0.05).
Conclusion: This finding revealed that 8 weeks Pilates training cannot be considerable impact on glucose, insulin, insulin resistance index and serum Irisin levels in obese women.

کلیدواژه‌ها [English]

  • Pilates
  • Obese
  • Insulin resistance index
  • Irisin
  1. Zakavi, I., Sharifi, M., Panahizadeh, M., & Valipour, A. A. (2014). Effect of Eight Weeks Roping on Interleukin 18 and Creactive protein The in Overweight and Obese Adolescents.
  2. Vazquez-Vela, M. E. F., Torres, N., & Tovar, A. R. (2008). White adipose tissue as endocrine organ and its role in obesity. Archives of medical research, 39(8), 715-728.
  3. Gesta, S., Tseng, Y. H., & Kahn, C. R. (2007). Developmental origin of fat: tracking obesity to its source. Cell, 131(2), 242-256.
  4. Joung, K. E., Park, K. H., Zaichenko, L., Sahin-Efe, A., Thakkar, B., Brinkoetter, M., ... & Mantzoros, C. S. (2014). Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults. The Journal of Clinical Endocrinology & Metabolism, 99(6), E1055-E1060.
  5. Handschin, C., & Spiegelman, B. M. (2008). The role of exercise and PGC1α in inflammation and chronic disease. Nature, 454(7203), 463-469.
  6. Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., ... & Kajimura, S. (2012). A PGC1-[agr]-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468.
  7. Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., ... & Pardo, M. (2013). FNDC5/irisin is not only a myokine but also an adipokine. PloS one, 8(4), e60563.
  8. Piya, M. K., Harte, A. L., Sivakumar, K., Tripathi, G., Voyias, P. D., James, S., ... & Kumar, S. (2014). The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes. American Journal of Physiology-Endocrinology and Metabolism, 306(5), E512-E518.
  9. Schumacher, M. A., Chinnam, N., Ohashi, T., Shah, R. S., & Erickson, H. P. (2013). The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer IMPLICATIONS FOR RECEPTOR ACTIVATION. Journal of Biological Chemistry, 288(47), 33738-33744.
  10. Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., ... & Yang, L. J. (2014). Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes, 63(2), 514-525.
  11. Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009). Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences, 106(48), 20405-20410.
  12. Hee Park, K., Zaichenko, L., Brinkoetter, M., Thakkar, B., Sahin-Efe, A., Joung, K. E., ... & Davis, C. R. (2013). Circulating irisin in relation to insulin resistance and the metabolic syndrome. The Journal of Clinical Endocrinology & Metabolism, 98(12), 4899-4907.
  13. Blüher, S., Panagiotou, G., Petroff, D., Markert, J., Wagner, A., Klemm, T., ... & Mantzoros, C. S. (2014). Effects of a 1‐year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity, 22(7), 1701-1708.
  14. Liu, J. J., Wong, M. D., Toy, W. C., Tan, C. S., Liu, S., Ng, X. W., ... & Lim, S. C. (2013). Lower circulating irisin is associated with type 2 diabetes mellitus. Journal of Diabetes and its Complications, 27(4), 365-369.
  15. Villarroya, F. (2012). Irisin, turning up the heat. Cell metabolism, 15(3), 277-278.
  16. Hashemi, A., Taghian, F., & Kargar Fard, M. (2015). Effect of Pilates for 8 Weeks on Cortisol and Lipid Profile in Obese Women. The Horizon of Medical Sciences, 20(4), 249-255.
  17. Segal, N. A., Hein, J., & Basford, J. R. (2004). The effects of Pilates training on flexibility and body composition: an observational study. Archives of physical medicine and rehabilitation, 85(12), 1977-1981.
  18. Kloubec, J. A. (2010). Pilates for improvement of muscle endurance, flexibility, balance, and posture. The Journal of Strength & Conditioning Research, 24(3), 661-667.
  19. Smith, K., & Smith, E. (2005). Integrating Pilates‐based Core Strengthening Into Older Adult Fitness Programs: Implications for Practice. Topics in Geriatric Rehabilitation, 21(1), 57-67.
  20. Bernardo, L. M. (2007). The effectiveness of Pilates training in healthy adults: An appraisal of the research literature. Journal of Bodywork and Movement Therapies, 11(2), 106-110.
  21. Azamian Jazi A ، Ghasemi Mobarekeh B، Vismeh Z، Parsa Gohar N(2015). Effect of 12 weeks of selected Pilates exercise training on serum adiponectin level and insulin resistance in female survivors of breast cancer and its role in prevention of recurrence. Scientific Journal of Kurdistan University of Medical. 20(5): 61-73. (Persian)
  22. Hew‐Butler, T., Landis‐Piwowar, K., Byrd, G., Seimer, M., Seigneurie, N., Byrd, B., & Muzik, O. (2015). Plasma irisin in runners and nonrunners: no favorable metabolic associations in humans. Physiological reports, 3(1), e12262.
  23. Kurdiova, T., Balaz, M., Vician, M., Maderova, D., Vlcek, M., Valkovic, L., ... & Jelok, I. (2014). Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. The Journal of physiology, 592(5), 1091-1107.
  24. Olefsky, J. M., Ciaraldi, T. P., & Kolterman, O. G. (1985). Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. The American journal of medicine, 79(3), 12-22.
  25. Tanner, C. J., Koves, T. R., Cortright, R. L., Pories, W. J., Kim, Y. B., Kahn, B. B., ... & Houmard, J. A. (2002). Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. American Journal of Physiology-Endocrinology And Metabolism, 282(1), E147-E153.
  26. Huh, J. Y., Mougios, V., Skraparlis, A., Kabasakalis, A., & Mantzoros, C. S. (2014). Irisin in response to acute and chronic whole-body vibration exercise in humans. Metabolism, 63(7), 918-921.
  27. Tsuchiya, Y., Ando, D., Goto, K., Kiuchi, M., Yamakita, M., & Koyama, K. (2014). High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. The Tohoku journal of experimental medicine, 233(2), 135-140.
  28. Daskalopoulou, S. S., Cooke, A. B., Gomez, Y. H., Mutter, A. F., Filippaios, A., Mesfum, E. T., & Mantzoros, C. S. (2014). Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. European journal of endocrinology, 171(3), 343-352.
  29. Soori R, Ravasi AA, HazratiMolaee S.(2015) . Comparing the Effects of High Intensity Endurance
  30. Training and Resistance Training on Irisin Levels and Insulin Resistance in Rats. Iranian Journal of Endocrinology and Metabolism. 17(3):pp224-229. (Persian)
  31. Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., ... & Fernandez-Real, J. M. (2013). Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 98(4), E769-E778.
  32. Dun, S. L., Lyu, R. M., Chen, Y. H., Chang, J. K., Luo, J. J., & Dun, N. J. (2013). Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience, 240, 155-162.
  33. Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pöllänen, E., ... & Alen, M. (2013). Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?. The Journal of physiology, 591(21), 5393-5400.
  34. Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., ... & Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS Journal, 281(3), 739-749.
  35. Ranjbar R، Ahmadizad S ، Khoshniat M، Salimi A.( 1391). Effect of endurance training with a period of fasting and exercise on plasma levels Adiponectin and insulin resistance in non-active men. Sport physiology. 15. PP163-180. (Persian)
  36. Poirier, P., Tremblay, A., Broderick, T. L., Catellier, C., Tancrède, G., & Nadeau, A. (2002). Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: is insulin sensitivity enhanced only in nonobese subjects?. Medical Science Monitor, 8(2), CR59-CR65.
  37. Goodpaster, B. H., Kelley, D. E., Wing, R. R., Meier, A., & Thaete, F. L. (1999). Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes, 48(4), 839-847.
  38. Sadiya, A., Ahmed, S., Siddieg, H. H., Babas, I. J., & Carlsson, M. (2011). Effect of Ramadan fasting on metabolic markers, body composition, and dietary intake in Emiratis of Ajman (UAE) with metabolic syndrome. Diabetes Metab Syndr Obes, 4, 409-16.
  39. Reinehr, T., Elfers, C., Lass, N., & Roth, C. L. (2015). Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis. The Journal of Clinical Endocrinology & Metabolism, 100(5), 2123-2130.
  40.