مقایسه تاثیر 8 هفته فعالیت تناوبی با شدت بالا و تداومی بر سطح پایه بیان پی سلکتین و شاخص‌های پلاکتی در بیماران قلبی- عروقی

نوع مقاله : علمی - پژوهشی

نویسندگان

1 دانشیار، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی

2 استاد، مرکز تحقیقات قلب و عروق شهید رجائی، دانشگاه علوم پزشکی ایران

3 دانشیار، مرکز تحقیقات قلب و عروق شهید رجائی، دانشگاه علوم پزشکی ایران

4 دانشجوی دکترای فیزیولوژی ورزش، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی

5 استادیار، عضو هیات علمی گروه علوم آزمایشگاهی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی کاشان

6 استادیار، مرکز تحقیقات قلب و عروق شهید رجائی، دانشگاه علوم پزشکی ایران

چکیده

هدف: پلاکت‌ها نقش مهمی را در علت شناسی بیماری‌های قلبی عروقی بازی می‌کنند. هدف از این تحقیق مقایسه تاثیر 8 هفته فعالیت تناوبی با شدت بالا و تداومی بر سطح پایه بیان پی سلکتین و شاخص‌های پلاکتی در بیماران قلبی-عروقی بود. روش شناسی:  به همین منظور تعداد 30 بیمار قلبی CABG و PCI به صورت داوطلبانه انتخاب و در سه گروه 10 نفره کنترل، تمرین تداومی و تمرین تناوبی با شدت بالا تقسیم شدند. آزمودنی‌های دو گروه تمرین به مدت 8 هفته و هفته ای سه جلسه تمرین ورزشی داشتند. زمان هر جلسه 40 دقیقه بود که فعالیت تناوبی شامل گرم کردن، 8 تکرار 4 دقیقه‌ای فعالیت (2 دقیقه فعالیت باشدت 90  درصد و 2 دقیقه استراحت فعال با شدت 30 درصد) و سرد کردن بود تمرین تداومی شامل 30 دقیقه فعالیت با شدت 60 درصد اوج اکسیژن مصرفی بود. گروه کنترل طی دوره تمرین هیچگونه فعالیت ورزشی نداشتند. نمونه‌های خونی قبل و بعد از هشت هفته گرفته شده و برای اندازه گیری پی سلکتین  به روش فلوسیتومتری و شاخص‌های پلاکتی آنالیز شد. از تحلیل واریانس مکرر با عامل بین گروهی و رگرسیون خطی چندگانه برای تحلیل آماری داده‌ها استفاده شد. نتایج: نتایج نشان داد بین تغییرات پی سلکتین در سه گروه تفاوت معنی‌دار وجود دارد (013/0=P). با مراجعه به آزمون تعقیبی بانفرونی مشاهده شد که بین تغییرات قبل و بعد از دروه تمرینی گروه کنترل و تمرین تناوبی تفاوت معتی داری وجود دارد (011/0=P). اما تغییرات شاخص‌های پلاکتی در سه گروه تفاوت معنی داری نشان نداد (05/0P>). بحث و نتیجه گیری:  براساس یافته‌های تحقیق حاضر می‌توان نتیجه گیری نمود که هشت هفته فعالیت ورزشی منجر به کاهش پی سلکتین می‌شود که این کاهش تحت تاثیر نوع فعالیت می‌باشد و با توجه به تاثیر بیشتر تمرین تناوبی در مقایسه با تمرین تداومی در بیماران قلبی-عروقی، می‌توان از تمرینات تناوبی نیز در برنامه بازتوانی این بیماران استفاده کرد.

عنوان مقاله [English]

Comparison of the effects of 8 weeks of high intensity interval training and continuous training on P-selectin expression and platelet indices in cardiovascular disease

چکیده [English]



Platelets play an important role in the etiology of cardiovascular disease. The aim of this study was to
compare the effects of 8 weeks of high intensity interval training and continuous training on P-selectin
expression and platelet indices in cardiovascular patients. Therefore, 30 CABG and PCI heart patient
voluntary participated and divided into three groups (n=10): control, continuous and high-intensity interval
group. Anthropometric characteristics and peak oxygen consumption was recorded before starting a workout.
Each session was 40 minutes. Interval session consists of warm-up, 8 reps/ four min (exercise: 2min, active
recovery: 2min, intensity: 90 /30) and cool down, but continues session includes 30 minutes of continuous
exercise intensity activity with 60% of peak oxygen consumption. The control group did not have a regular
activity. Blood samples taken before and after the eight-week and their P-selectin (by flow cytometry) and
platelet indices were measured. Repeated measure ANOVA with between group factor and multiple linear
regression were used for statistical analysis. The results showed that P-selectin expression changes between
the groups were significantly different (P=.013). Post-hoc test show that the changes between control and
interval groups were significant (P=.011). But no significant changes were observed in all platelet indices
(P>0.05).It is concluded that eight weeks of exercise leads to reduction in P-selectin expression that was also
affected by type of activity. Based on more effects of interval training in cardiovascular patients, use of
interval training can be suggested in their rehabilitation program.

کلیدواژه‌ها [English]

  • P-selectin
  • high intensity interval training
  • platelet indices
  • CABG
  • PCI

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سابقه مقاله

  • تاریخ دریافت: 23 شهریور 1395
  • تاریخ بازنگری: 22 خرداد 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 خرداد 1395

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