تأثیر تمرین مقاومتی دایره‌ای بر غلظت سرمی واسپین و شاخص‌ مقاومت انسولینی در بیماران مبتلا به دیابت نوع 2

نوع مقاله : علمی - پژوهشی

نویسندگان

1 داﻧﺸﮕﺎه آزاد اﺳﻼﻣﯽ واﺣﺪ ﺳﺎری

2 داﻧﺸﮕﺎه ﻣﺎزﻧﺪران

چکیده

مقدمه: مقاومت انسولینی در پاتولوژی دیابت نقش مهمی دارد. واسپین، آدیپوکین جدیدی است که در افزایش‌ حساسیت انسولین و بهبود تحمّل گلوکز نقش دارد. اطلاعات اندکی در مورد تأثیر تمرین منظم ورزشی به ویژه تمرین مقاومتی بر غلظت واسپین وجود دارد. از این‌رو هدف پژوهش حاضر بررسی تأثیر تمرین مقاومتی دایره‌ای بر غلظت پلاسمایی واسپین، شاخص‌ مقاومت انسولینی و ارتباط آن‌ها در مردان بزرگسال مبتلا به بیماری دیابت نوع 2 می‌باشد. روش‌‌ شناسی: 18 مرد بزرگسال مبتلا به دیابت نوع 2 (سن 73/7 ± 50/48 سال، وزن 60/12±41/79 کیلوگرم) به طور تصادفی به گروه‌های تجربی (تعداد 10 نفر) و کنترل (تعداد 8 نفر) تقسیم شدند. گروه تجربی در برنامه تمرین مقاومتی (3 روز در هفته، برای 8 هفته) با شدت 50 تا 80 درصد یک تکرار بیشینه شرکت کردند. نمونه‌گیری خون قبل و بعد از دوره تمرینی در حالت ناشتا 12 ساعته انجام شد و سطوح واسپین، گلوکز، انسولین و شاخص مقاومت انسولینی با روش الایزا اندازه‌گیری شدند. پس از سنجش متغیرها و تحلیل آماری با استفاده از آزمون t مشخص شد که: نتایج: پس از 8 هفته تمرین مقاومتی، سطوح گلوکز، انسولین و مقاومت به انسولین در گروه تمرین مقاومتی نسبت به گروه کنترل، به‌طور معنا‌داری کاهش یافتند (مقدار p به ترتیب برابر با 040/0، 021/0 و 011/0). در حالی‌که غلظت سرمی واسپین در گروه تمرین مقاومتی در مقایسه با گروه کنترل تغییر معناداری نشان نداد (380/0p=). هم-چنین ارتباط معناداری بین غلظت سرمی واسپین و گلوکز، انسولین و شاخص‌ مقاومت انسولینی در بین دو گروه مشاهده نشد. بحث و نتیجه‌گیری: نتایج پژوهش حاضر حاکی از آن است که تمرین مقاومتی دایره‌ای می‌تواند به عنوان یک عامل موثر در بهبود حساسیت انسولینی در بیماران دیابتی نوع 2 به‌کار گرفته شود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of circuit resistance training on serum vaspin concentration and insulin resistance in patients with type 2 diabetes

چکیده [English]


Introduction: Insulin resistance has an important role in the pathology of diabetes. Vaspin is a novel adipokine that
has a role in increase insulin sensitivity and improve glucose tolerance. There is limited information available
regarding the effect of regular exercise, particularly resistance training on serum vaspin concentrations. The purpose
of this study was to investigate the effect of Circuit Resistance training on serum vaspin levels, Insulin resistance
and its relation In adult men with type 2 diabetes. Methods: 18 adult men with type 2 diabetes (age: 48.50±7.73 yr,
weight: 79.41±12.60 kg) were randomly assigned to experimental (n= 10) and control (n= 8) groups. Experimental
group participated in a resistance training program (3 days a week for 8 weeks) with an intensity of 50 to 80% of
one repetition maximum. Blood samples collected in the 12-hour fasting state before and after training period and
levels of vaspin, insulin, glucose and insulin resistance index (HOMA-IR) were measured by ELISA method. After
evaluating variables and statistical analysis with t- test, It was found that: Results: After a 8 week resistance
training, levels of glucose, insulin and insulin resistance index (HOMA-IR) were significantly decreased (P= 0.040,
0.012 and 0.011, respectively). Whereas, serum vaspin concentration showed no significant changes in resistance
trained group when compared with their control groups (p=0/380). Also, no significant correlation between Serum
vaspin concentration and levels of glucose, insulin and HOMA-IR were observed between the two groups.
Conclusion: The results of the present study suggest that circuit resistance training can be used as an effective factor
in improving of insulin sensitivity in type 2 diabetic patients.

کلیدواژه‌ها [English]

  • Diabetes mellitus
  • Vaspin
  • Circuit resistance training

مراجع

  1. منابع
  2. - Raghow R. (2012). Metabolic balancing acts of
  3. vitamin a in type-2 diabetes and obesity. World
  4. Journal of Diabetes. 3(10):174-7.
  5. - Onat D, Brillon D, Colombo P, Schmidt A.
  6. (2011). Human vascular endothelial cells: a
  7. model system for studying vascular inflammation
  8. in diabetes and atherosclerosis. Current Diabetes
  9. Reports. 11(3): 193–202.
  10. - Olefsky J, Glass K. (2010). Macrophages,
  11. inflammation, and insulin resistance. Annual
  12. Review of Physiology. 72: 219–46.
  13. - Belfiore A, Malaguarnera R. (2011). Insulin
  14. receptor and cancer. Endocrine-related cancer.
  15. (4): 25-47.
  16. - Mlinar B, Marc J, Janez A, Pfeifer M. (2007).
  17. Molecular mechanisms of insulin resistance and
  18. associated diseases. Clinica Chimica Acta.
  19. (2): 20-35.
  20. - Defronzo RA. (2009). From the triumvirate to the
  21. ominous octet: a new paradigm for the treatment
  22. of type 2 diabetes mellitus. Diabetes. 58(4): 773-
  23.  
  24. - Hida K, Wada J, Eguchi J, Zhang H, Baba M,
  25. Seida A, et al. (2005). Visceral adipose tissuederived
  26. serine protease inhibitor: a unique insulinsensitizing
  27. adipocytokine in obesity. Proceedings
  28. of the National Academy of Sciences. 102(30):
  29. -5.
  30. - Flack KD, Davy KP, Hulver MW, Winett RA,
  31. Frisard MI, Davy BM. (2010). Aging, resistance
  32. training and diabetes prevention. Journal of Aging
  33. Research. 2011:1-12.
  34. - Praet SF, van Loon LJ. (2009). Exercise therapy in
  35. type 2 diabetes. Acta Diabetologica. 46(4): 263–
  36.  
  37. - Knowler WC, Barrett-Connor E, Fowler SE,
  38. Hamman R, Lachin J, Walker E, et al. (2002).
  39. Reduction in the incidence of type 2 diabetes with
  40. lifestyle intervention or metformin. The New
  41. England Journal of Medicine. 346( 6): 393–403.
  42. - Ghosh S, Khazaei M, Moien-Afshari F, Ang LS,
  43. Granville DJ, Verchere CB, et al. (2009).
  44. Moderate exercise attenuates caspase-3 activity,
  45. oxidative stress, and inhibits progression of
  46. diabetic renal disease in db/db mice. American
  47. Journal of Physiology - Renal Physiology. 296(4):
  48. –708.
  49. - Boule NG, Haddad E, Kenny GP, Wells GA,
  50. Sigal RJ. (2001). Effects of exercise on glycemic
  51. control and bodymass in type 2 diabetes mellitus:
  52. a meta-analysis of controlled clinical trials.
  53. Journal of the American Medical Association.
  54. (10): 1218–1227.
  55. - Eves ND, Plotnikoff RC. (2006). Resistance
  56. training and type 2 diabetes: considerations for
  57. implementation at the population level. Diabetes
  58. Care. 29(8): 1933-41.
  59. - Ibanez J, Izquierdo M, Arguelles I, Forga L,
  60. Larrion JL, Garcia-Unciti M, et al. (2005). Twiceweekly
  61. progressive resistance training decreases
  62. abdominal fat and improves insulin sensitivity in
  63. older men with type 2 diabetes. Diabetes Care.
  64. (3): 662–667.
  65. - Safarzade A, Gharakhanlou R, Hedayati M,
  66. Talebi-Garakani E. (2012). The effect of 4 weeks
  67. resistance training on serum vaspin, il-6, crp and
  68. tnf-α concentrations in diabetic rats. Iranian
  69. Journal of Endocrinology and Metabolism.
  70. (1).68-74.
  71. - Kyung Han T, hyun k. (2012). Effects of acute
  72. exercise on serum vaspin and insulin resistance in
  73. normal and pre-diabetes middle-aged women.
  74. Journal of Exercise Nutrition and Biochemistry.
  75. (1): 11-17.
  76. - Young KJ, Sung Kim E, Justin Y, Jekal Y.
  77. (2011). Improved insulin resistance, adiponectin
  78. and liver enzymes without change in plasma
  79. vaspin level after 12 weeks of exercise training
  80. among obese male adolescents. Korean Journal of
  81. Obesity. 20(3): 138-146.
  82. تأثیر تمرین مقاومتی دایرهای بر غلظت سرمی واسپین و شاخص مقاومت انسولینی در بیماران مبتلا به دیابت نوع 2
  83. - Youn BS, Kloting N, Kratzsch J, et al. (2008).
  84. Serum vaspin concentrations in human obesity
  85. and type 2 diabetes. Diabetes. 57(2): 372–7.
  86. - Kyung CJ, Kyung HT, Kang HS. (2010).
  87. Combined effects of body mass index and
  88. cardio/respiratory fitness on serum vaspin
  89. concentrations in korean young men. European
  90. Journal of Applied Physiology. 108(2): 347-53.
  91. - Hordern Md, Dunstan Dw, Prins Jb, Baker Mk,
  92. Fiatarone Singh Ma, Coombesb J. (2012).
  93. Exercise prescription for patients with type 2
  94. diabetes and pre-diabetes:a position statement
  95. from exercise and sport science australia. Journal
  96. of Science and Medicine in Sport. 15(1): 25-31.
  97. - Dunstan DW, Daly RM, Owen N, Jolley D, De
  98. Courten M, Shaw J, et al. (2002). High-intensity
  99. resistence traning improves glycemic control in
  100. older patients with type 2 diabetes. Diabetes Care.
  101. : 1729–1736.
  102. - Kwon h, Han k, Ku y, Ahn h, Koo b, Kim h, et
  103. al. (2010). The effects of resistance training on
  104. muscle and body fat mass and muscle strength in
  105. type 2 diabetic women. Korean Diabetes J.
  106. :101-110.
  107. - Oberbach A, Kirsch K, Lehmann S, Schlichting
  108. N, Fasshauer M, Zarse K et al. (2010). Serum
  109. vaspin concentrations are decreased after
  110. exercised-induced oxidative stress. Obesity Facts.
  111. (5): 328-330.
  112. - Lee MK, Jekal Y, Im JA, Kim E, Lee SH, Park
  113. JH, et al. (2010). Reduced serum vaspin
  114. concentrations in obese children following shortterm
  115. intensive lifestyle modification. Clin Chim
  116. Acta. 411:381-5.
  117. - Kim SM, Cho GJ, Yannakoulia M, Hwang TG,
  118. Kim IH, Park EK. (2011). Lifestyle modification
  119. increases circulating adiponectin concentrations
  120. but does not change vaspin concentrations.
  121. Metabolism. 60(9): 1294-9.
  122. - Koiou E, Kalaitzakis E, Tziomalos K, Mavridis
  123. S, Dinas K, Tantanasis T, et al. (2011). Vaspin: a
  124. novel adipokine, member of the family of serine
  125. protease inhibitors. Aristotle University Medical
  126. Journal. 38(3): 7-18.
  127. - You min W, Wen-ping W, Li-ping W, Qi-huan
  128. L, Xiao-hui Z. (2010). Calorie control increased
  129. vaspin levels of serum and periepididymal
  130. adipose tissue in diet-induced obese rats in
  131. association with serum free fatty acid and tumor
  132. necrosis factor alpha. Chinese Medical Journal.
  133. (7): 936-941.
  134. - Shavandi N, Shahrjerdi S, Sheikh Hoseini R,
  135. Ghorbani A. (2010). The effect of strengthening
  136. exercises on metabolic factors, quality of life and
  137. mental health in women with type 2 diabetes.
  138. Iranian Journal of Endocrinology and
  139. Metabolism. 12(3).222-230.
  140. - Balducci S, Zanuso S, Cardelli P, Salvi L,
  141. Mazzitelli G, Bazuro A, et al. (2012). Changes in
  142. physical fitness predict improvements in
  143. modifiable cardiovascular risk factors
  144. independently of body weight loss in subjects
  145. with type 2 diabetes participating in the Italian
  146. Diabetes and Exercise Study. Diabetes Care.
  147. (6): 1347-54.
  148. - Kwon. HR, Han. KA, Ku. YH, Ahn. HJ, Koo.
  149. BK, Kim. HC. et al. (2010). The effects of
  150. resistance training on muscle and body fat mass
  151. and muscle strength in type 2 diabetic women.
  152. Korean Diabetes journal. 34: 101-110.
  153. - Hordern. MD, Cooney. LM, Beller. EM, Prins.
  154. JB, Marwick. TH and Coombes. JS. (2008).
  155. Determinants of changes in blood glucose
  156. response to short-term exercise training in
  157. patients with Type 2 diabetes. Clinical Science.
  158. , 273–281.
  159. - Feng RN, Wang C, Sun CH, Guo FC, Zhao C
  160. Lia Y. (2011). Vaspin in newly and previously
  161. diagnosed Chinesetype 2 diabetic females: a casecontrol
  162. study. Asian Biomed. 5(4): 525-529.
  163. - Kraus WE, Houmard JA, Duscha BD, Knetzger
  164. KJ, Wharton MB, Jennifer S, McCartney JS, et al.
  165. (2002). Effects of the amount and intensity of
  166. exercise on plasma lipoproteins. New England
  167. Journal of Medicine. 347(19): 1483-1492

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سابقه مقاله

  • تاریخ دریافت: 27 اردیبهشت 1394
  • تاریخ بازنگری: 29 خرداد 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 اردیبهشت 1391

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