مقایسه سه شیوه تمرین ورزشی بر غلظت پروتئین واکنش‌دهندهC و گلبول‌های سفید خونی در بیماران دیابتی نوع2

نوع مقاله : علمی - پژوهشی

نویسندگان

1 دانشیار فیزیولوژی ورزشی دانشگاه بوعلی همدان

2 کارشناسی ارشد فیزیولوژی ورزش دانشگاه بوعلی همدان

چکیده

چکیدههدف: دیابت از جمله بیماری‌هایی است که باعث کاهش عملکرد سیستم دفاعی بدن در برابر عفونت‌ها می‌شود. از گونه میانجی‌های التهابی که به‌دنبال فعل‌و‌انفعالات التهاب در کنار گلبول‌های سفید ترشح می‌شود، پروتئین واکنش‌دهنده(CRP) C  است، که نشانگر حساسی برای التهاب سیستمیک محسوب می‌شود. تمرین منظم با کنترل سوخت و ساز در دیابتی‌ها باعث کنترل قند خون می‌شود و به‌دنبال آن پاسخ دفاعی بدن را افزایش می‌دهد. به‌همین منظور این مطالعه به‌مقایسه اثر سه شیوه تمرین ورزشی بر CRPو گلبول‌های سفید در بیماران دیابتی نوع II  طراحی شده است. روش شناسی: در این پژوهش، 52 بیمار مرد دیابتی نوعII (65-40 سال) بطور تصادفی به 4 گروه تمرینی هوازی، مقاومتی، ترکیبی و کنترل تقسیم شدند. در هر گروه 13 نفر قرار گرفت. تمرینات سه جلسه در هفته، هر جلسه 60 دقیقه بمدت 10هفته بطول انجامید. hs-CRP  به روش الایزا و شمارش عناصر WBC در ابتدا و پایان مطالعه اندازه‌گیری شد.  نتایج: یافته‌ها تحقیق نشان داد که تمرینات هوازی بطور معنی‌داری باعث کاهشhs-CRP و افزایش مونوسیت‌ها شد. همچنین تمرینات ترکیبی نیز باعث کاهش سطح CRP و نوتروفیل‌ها و افزایش مونوسیت‌ها و لنفوسیت‌ها شد. کاهش CRP در گروه ترکیبی نسبت به گروه هوازی بتنهایی بارزتر بود ولی در عناصرWBC تفاوتی نداشت. بحث و نتیجه‌گیری: براساس یافته‌های پژوهش تجویز تمرینات ورزشی هوازی و بویژه ترکیبی می‌تواند روش مناسب برای جلوگیری از بروز عوارض دیابت نوع IIباشد.   

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of three exercise training method on plasma CRP levels and WBC in patients with type II diabetes

چکیده [English]



Purpose Diabetes is a disease that causes a decrease in the function of the immune system of the body against infections.
One of the inflammatory mediators, secreted along the white corpuscles after the interactions of inflammation, is CRP,
which is a sensitive marker for systemic inflammation. Regular exercise with controlling metabolism in diabetes controls
the blood glucose level and subsequently increases the immune response of body. For this purpose, this study has been
designed to compare three different ways of training on CRP and WBC levels in type 2 diabetic patients. Methods: 52
patients with type 2 diabetes (40-65 years old) were randomly divided into four groups: aerobic training, resistance,
combined (aerobic and resistance) and control groups and each group consisted of 13 subjects. The exercises were done 3
times a week for 60 minutes each session and lasted for 10 weeks. The WBC counts and high-sensitivity CRP (hs-CRP) at
baseline and at the end of the study were measured by ELISA. Results: The research findings showed significant
reduction in hs-CRP and increased MONO, aerobic exercise group and decrease in CRP and NEUT levels and increase in
MONO and LYM were seen in the combination group. CRP in the combination group was significantly higher than
aerobic alone, but no difference in WBC groups was noticed. Conclusions: According to the findings, the research
prescribes aerobic exercise training can be a particularly suitable compound to prevent complications of type 2 diabetes.

کلیدواژه‌ها [English]

  • C-reactive protein
  • white blood cell
  • exercise training
  • type 2 diabetes
  1. منابع
  2. Festa A, D’Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM. (2002).) Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation; 102(1):42-7
  3. WHO. ;(1999). Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Department of Noncommunicable Disease Surveillance. Geneva. WHO.
  4. Russo AF, Dickerson IM. (2006). CGRP: A multifunctional neuropeptide. In: Lim R, editor. Handboook of Neurochemistry and Molecular Neurobiology. 3rd. springer-Verlag Berlin Heidelberg;. P 390-426.
  5. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. (2001). Low-grade systemic inflammation in overweight children. Pediatrics; 107:E13.
  6. Peter P. The immune system is body. translator, Niknam, kaghazian M, Tehran, vafagh (1384), vol 1 (Persian)
  7. McLaughlin, T., FahimLamendola, CindyLiang, LynnReaven, GeraldSchaaf, PatriciaReaven, Peter. (2002). "Differentiation between obesity and insulin resistance in the association with C-reactive protein." Circulation.106(23): 2908-2912.
  8. Bots, M. L. L. Lenore J Lindemans, Jan Hoes, Arno W Hofman, Albert Witteman, Jacqueline Koudstaal, Peter J Grobbee, Diederick E. (1999). Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam Study. Archives of internal medicine. 159(1): 38
  9.  
  10. Hotamisligil, G. S. S., Narinder S Spiegelman, Bruce M. (1993). Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science.259(5091): 87-91.
  11. Barzilay JI, Abraham L, Heckbert SR, et al. (2001). The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes; 50: 2384–2389
  12. Dehghan A, Kardys I, de Maat MP, et al. (2007). Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes;56:872–878
  13. Duncan BB, SchmidtMI, Pankow JS, et al.; (2003). Atherosclerosis Risk in Communities Study. Low-grade systemic inflammation and the development of type 2 diabetes: the Atherosclerosis Risk in Communities Study. Diabetes;52:1799–1805
  14. Festa A, D’Agostino R Jr, Tracy RP, Haffner SM; (2002). Insulin Resistance Atherosclerosis Study. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes;51:1131–1137
  15. Kasapis C, Thompson P. (2005). The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers: A Systematic Review. Journal of the American College of Cardiology; 45(10):1563-9.
  16. Frydelund-Larsen L, Akerstrom T, Nielsen S, Keller P, Keller C, Pedersen BK. (2007).VisfatinmRNA expression in human subcutaneous adipose tissue is regulated by exercise. Am J Physiol Endocrinol Metab; 292(1): E24-31.
  17. Ellinger, V., Carlini, L. T., Moreira, R. O., & Meirelles, R. M. (2006). Relation between insulin resistance and hematological parameters in a Brazilian sample. Arquivos Brasileiros de Endocrinologia & Metabologia, 50(1), 114-117.
  18. Harrison T, Cecil, Lafayette R. Hematology and Oncology, translation: khodaamorzide D.(1388), Tehran , lofty thoughts. (Persian)
  19. Nyström T. (2007). C-reactive protein: a marker or a player? Clin Sci (Lond); 113(2):79-81.
  20. Balducci, S., SNicolucci, AFernando, FCavallo, SCardelli, PFallucca, SAlessi, ELetizia, CJimenez, A. (2010). "Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss." Nutrition, Metabolism and Cardiovascular Diseases. 20(8): 608-617.
  21. Jorge, M. L. M. P., de Oliveira, V. N., Resende, N. M., Paraiso, L. F., Calixto, A., Diniz, A. L. D., & Geloneze, B. (2011). The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism, 60(9), 1244-1252.
  22. zamani M. (1391). Effect of 8 week aerobic exercise on hematological parameters dependent on morphine withdrawal syndrome. MA thesis Faculty of Literature and Human Sciences, Bu-Ali Sina University (Persian)
  23. Nikseresht, A., Sh, F. H., Solhjoo, K., & Kargar Jahromy, H. (2013). Effect of maximum activity on the immune system cells in diabetic rats. Journal of Jahrom University of Medical Sciences, 10(4), 43.
  24. Çakamakci, E., Sanioglu, A., Vatansev, H., & Marakoglu, K. (2010). The effects of 8-week step-aerobic exercise on the body composition and hematologlic parameters in the obese and overweight females. Sci Mov Health, 10, 808-813.
  25. Mel nikov AA, Kylosov AA, Vikulov AD. (2007). Relationships of Inflammatory Activitywith biochemical parameters of the blood and sympathovagal balance of young athletes.Human Physiology,vol.33,No.5. PP624-631.
  26. Shin .Y, Keun Oh. J, Sik Sohn. H, Sang Bae. J,Young Lee. M , Beom Lee J, Mo Yang .H,Ki Min .Y, Yeon Song H, Kyune Ko. K, Matsumot.T(2004). Expression of exercise-induced HSP70 in long-distance runner’s leukocytes, Journal of Thermal Biology, 29:769–774.
  27. Bhatti R, Shaikh D, (2007). The effect of exercise on blood parameters, Pak J Physiology;3(2).
  28. Bobeuf, F., Labonte, M., Khalil, A., & Dionne, I. J. (2009). Effect of resistance training on hematological blood markers in older men and women: a pilot study. Current gerontology and geriatrics research,
  29. Karanysh M, Islami S, Marandi S, zandmoghadam A and Hqyqyzadh M., ( 1387). Effect of protein whey supplementation on blood parameters in healthy young Drvrzshkaran resistance activities. Journal of Endocrinology. Shaheed Beheshti University of Medical Sciences (period I, No. Y4, page-Hay373-379)( Persian)
  30. Arazi H, Damirchi A, Mostafalu, Ardabil. (1390). Changes in haematological parameters after repeated sessions of resistance training and endurance simultaneously. University Journal of Medical Sciences. Volume 9, Volume 2 (Persian)
  31. Abul Abbas, Laytmn A, Play S , Translator Mohamdnya M, (1391). amozegar A Cellular and molecular immunology ,Tehran: the next generation (Persian)
  32. Alba-Loureiro, T, Hirabara, S., Mendonca, J, Curi, R, & Pithon-Curi, T. (2006). Diabetes causes marked changes in function and metabolism of rat neutrophils. Journal of endocrinology, 188(2), 295-3
  • تاریخ دریافت: 08 اسفند 1395
  • تاریخ بازنگری: 22 خرداد 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 آذر 1395