تأثیر هشت هفته تمرین یوگا بر سطوح سرمی اینترلوکین 6، اینترلوکین 10، فاکتور نکروز توموری آلفا و ترکیب بدن در زنان مبتلا به مولتیپل اسکلروزیس

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه علوم ورزشی، دانشکدة علوم انسانی، دانشگاه سمنان، سمنان، ایران

چکیده

زمینه و هدف: مولتیپل اسکلروزیس شایع‌ترین بیماری دمیلینه‌کنندة التهابی خودایمنی سیستم عصبی مرکزی است که بر آکسون‌های میلین‌دار سیستم عصبی مرکزی تأثیر می‌گذارد و سبب زوال عصبی می‌شود. میزان شیوع این بیماری در زنان سه برابر مردان گزارش شده است. در سال‌های اخیر، تعداد بیشتری از افراد مبتلا به این بیماری در پی روش‌های درمانی جایگزین دارو برای مدیریت علائم بیماری، از جمله درمان‌های ذهن و بدن مانند یوگا، مدیتیشن، تنفس و تکنیک‌های تمدد اعصاب بوده‌اند. پژوهش حاضر با هدف بررسی تأثیر هشت هفته تمرین یوگا بر سطوح سرمی فاکتور نکروز توموری آلفا، اینترلوکین 6 و اینترلوکین 10 و ترکیب بدن در زنان مبتلا به مولتیپل اسکلروزیس انجام گرفت.
مواد و روش‌ها: در این تحقیق نیمه‌تجربی، 20 نفر از زنان مبتلا به بیماری مولتیپل اسکلروزیس مراجعه‌کننده به مراکز درمانی شهرستان سمنان (میانگین سن 10/6±75/36 سال و شاخص تودة بدنی 02/6±88/26 کیلوگرم بر مترمربع) و با شاخص 5/3 >EDSS انتخاب و به‌طور تصادفی به دو گروه تمرین یوگا (10n=) و کنترل (10n=) تقسیم شدند. گروه تجربی به مدت هشت هفته و سه جلسه در هفته (24 جلسه) به تمرین یوگا در سالن سرپوشیده با دمای 25 تا 26 درجة سانتی‌گراد پرداختند. تعداد حرکات جلسة تمرین 15 حرکت در دو نوبت ده‌ثانیه‌ای بود و هر دو هفته پنج ثانیه به مدت هر حرکت تمرینی و یک حرکت جدید طبق اصل اضافه ‌بار به پروتکل تمرین اضافه شد که در انتهای هشت هفته به 18 حرکت و 15 ثانیه رسید. به‌منظور کنترل فشار تمرین از مقیاس RPE و بر اساس مقیاس بورگ استفاده شد. گروه کنترل طی این هشت هفته، فعالیت بدنی منظمی نداشتند و فقط به فعالیت‌های روزمره پرداختند. تجزیه‌وتحلیل آماری داده‌ها از طریق آزمون تحلیل واریانس با اندازه‌گیری مکرر و آزمون تی مستقل و تی وابسته در سطح معناداری 05/0P≤ انجام گرفت.
نتایج: یافته‌های پژوهش حاضر کاهش معناداری را در سطوح سرمی فاکتور نکروز توموری آلفا، اینترلوکین 6 و اینترلوکین 10 در گروه تجربی نسبت به گروه کنترل پس از هشت هفته تمرین نشان داد (001/0P=)؛ اما تفاوت معناداری در ترکیب بدن زنان مبتلا به مولتیپل اسکلروزیس پس از هشت هفته یوگا در مقایسه با گروه کنترل مشاهده نشد (05/0P≥).
نتیجه‌گیری: نتایج این پژوهش نشان داد که هشت هفته تمرین یوگا می‌تواند با کاهش سایتوکاین‌های التهابی، مانند فاکتور نکروز توموری آلفا و اینترلوکین 6 به‌عنوان یک راهکار درمانی مکمل در کنار درمان‌های دارویی برای بیماران مولتیپل اسکلروزیس استفاده شود.
 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of eight-week yoga training on serum levels of interleukin 6, interleukin 10, tumor necrosis factor alpha and body composition in women with multiple sclerosis

نویسندگان [English]

  • Elham Maddah
  • Seyed Mohsen Avandi
  • Rouhollah Haghshenas
  • Hossein Porhabibi
Department of Sport Sciences, Faculty of Humanities, Semnan University, Semnan, Iran
چکیده [English]

Background and Purpose: Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system that affects the myelinated axons of the central nervous system and causes neurological deterioration. The prevalence of this disease in women is reported to be 3 times that of men. In recent years, more people with the disease have sought alternative drug therapies to manage symptoms, including mind-body therapies such as yoga, meditation, breathing, and relaxation techniques. The present study was conducted with the aim of investigating the effect of eight weeks of yoga training on the serum levels of tumor necrosis factor alpha, interleukin 6, interleukin 10 and body composition in women with multiple sclerosis.
Materials and Methods: In this semi-experimental study, 20 women with multiple sclerosis who were referred to the medical centers of Semnan city (mean±SD; age, 36.75±6.10 years; body mass index, 26.88±6.02 kg/m2; and with EDSS index >3.5) were selected and randomly divided into two groups of yoga training (n=10) and control (n=10). The experimental group performed yoga training for eight weeks, three sessions per week (24 sessions) in an indoor hall with a temperature of 25-26°C. The training protocol started with performing two sets of 10 seconds for 15 movements and to observe the overload principle every two weeks, 5 seconds were added for each training movement and one movement was added to the training protocol, where at the final week number of movements reached 18 movements and 15 seconds. During this period, the control group had no regular physical activity and had normal daily activities. In order to determine and control the training pressure, the Borg’s rate of perceived exertion (RPE) scale was used. Statistical analysis of the data was performed by using the repeated measures of ANOVA, independent t-test and dependent t-test at a significance level of p≤0.05.
Results: The results of this study showed a significant decrease in the serum levels of tumor necrosis factor alpha, interleukin 6 and interleukin 10 in the experimental group compared to the control group after eight weeks of training (p=0.001). However, no significant difference was observed in the body composition of women with multiple sclerosis compared to the control group after eight weeks of yoga (p>0.05).
Conclusion: Finally, the results of this research showed that eight weeks of yoga training by reducing inflammatory cytokines and adjusting the serum index of tumor necrosis factor alpha and interleukin 6, can be used as a complementary treatment along with drug treatments for patients with multiple sclerosis.
 

کلیدواژه‌ها [English]

  • Yoga
  • Interleukin 6
  • Interleukin 10
  • Tumor Necrosis Factor alpha
  • Multiple Sclerosis

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سابقه مقاله

  • تاریخ دریافت: 03 اردیبهشت 1403
  • تاریخ بازنگری: 28 تیر 1403
  • تاریخ پذیرش: 02 مرداد 1403
  • تاریخ اولین انتشار: 02 مرداد 1403
  • تاریخ انتشار: 01 شهریور 1403

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