تأثیر فعالیت ورزشی حاد بر عامل رشد اندوتلیال عروقی در بزرگسالان: مروری نظام‌مند با فراتحلیل

نوع مقاله : مقاله مروری

نویسندگان

گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه کاشان، کاشان، ایران

چکیده

زمینه و هدف: عامل رشد اندوتلیال عروق (VEGF) مهم‌ترین شاخص آنژیوژنز است که ممکن است در پاسخ به فعالیت ورزشی افزایش پیدا کند. با این همه، آثار حاد فعالیت ورزشی بر این شاخص متناقض گزارش شده است. ازاین‌رو هدف تحقیق حاضر فراتحلیل حاضر بررسی اثر حاد فعالیت ورزشی بر VEGF گردش خون در بزرگسالان است.
مواد و روش‌ها: به‌منظور استخراج مقالات اصیل، جست‌وجوی جامع در پایگاه‌های اطلاعاتی PubMed ,Scopus ,Web of Science، مرکز جهاد دانشگاهی، مگیران و Google Scholar تا تاریخ 10 اسفند 1401 برای مطالعات فعالیت ورزشی حاد بر سطوح گردش خونی VEGF انجام گرفت. معیارهای ورود به فراتحلیل شامل مطالعات چاپ‌شده در مجلات فارسی‌زبان و انگلیسی‌زبان، مطالعات با آزمودنی‌های انسان با میانگین سنی بیشتر از 18 سال، مطالعات بررسی‌کنندۀ اثر حاد فعالیت ورزشی و مطالعات با اندازه‌گیری مقادیر سرمی یا پلاسمایی VEGF بود. برای تعیین اندازة اثر مقادیر تفاوت میانگین استانداردشده (SMD) و فاصلة اطمینان 95 درصد (CIs) با استفاده از نرم‌افزار CMA2 محاسبه شد. سطح ناهمگونی با استفاده از آزمون I2 و سوگیری انتشار نیز با آزمون Egger بررسی شد. همچنین تحلیل زیرگروهی برای وضعیت سلامتی (دارای بیماری مزمن و سالم) و نوع فعالیت ورزشی (هوازی، مقاومتی و تناوبی با شدت بالا) انجام گرفت.
 نتایج: روی‌هم‌رفته 27 مقاله (49 مداخلة ورزشی) شامل 704 آزمودنی وارد فراتحلیل حاضر شدند. نتایج تحلیل داده‌ها نشان داد که فعالیت ورزشی حاد به تغییرات معنادار در VEGF بلافاصله پس از فعالیت ورزشی نسبت به پیش از فعالیت ورزشی منجر نمی‌شود [14/0P= ,(40/0 تا 05/0CI: -) 17/0]. نتایج تحلیل زیرگروهی بر پایة وضعیت سلامت آزمودنی نشان داد که فعالیت ورزشی اثر معناداری بر VEGF در افراد سالم نداشت [40/0 P=،10/0SMD: ]، درحالی‌که تمایل به افزایش VEGF در بیماران شد [05/0 P=،30/0SMD: ]. نتایج تحلیل زیرگروهی بر پایة نوع فعالیت ورزشی نیز نشان داد که فعالیت ورزشی مقاومتی [008/0P=، 58/0SMD: ] به افزایش معنادار و فعالیت ورزشی تناوبی با شدت بالا [06/0P= ,29/0SMD: ] به افزایش غیرمعناداری VEGF منجر می‌شود، درحالی‌که اثر فعالیت ورزشی هوازی [95/0P= ,009/0SMD: ] معنادار نبود.
نتیجه‌گیری: روی‌هم‌رفته یافته‌های فراتحلیل حاضر نشان می‌دهد که نوع فعالیت ورزشی نقش مؤثری در پاسخ VEGF به فعالیت ورزشی حاد ایفا می‌کند. فعالیت ورزشی مقاومتی و تناوبی با شدت بالا ممکن است به افزایش VEGF گردش خون بلافاصله پس از فعالیت ورزشی منجر شوند، درحالی‌که فعالیت هوازی تأثیر چشمگیری ندارد. همچنین فعالیت ورزشی ممکن است VEGF را در افراد با بیماری‌های سوخت‌وسازی-قلبی افزایش دهد، درحالی‌که در افراد بدون بیماری مزمن مؤثر نباشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of acute exercise on vascular endothelial growth factor in adults: a systematic review with meta-analysis

نویسندگان [English]

  • Mohammad Javad Pourvaghar
  • Saeid reza Noorimofrad
  • Mousa Khalafi
Department of Physical Education and Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran
چکیده [English]

Background and Purpose: Vascular endothelial growth factor (VEGF) is the most important marker of angiogenesis that may increase in response to exercise. However, the effect of acute exercise on this marker has been reported inconsistently. Therefore, the aim of this systematic review and meta-analysis is to investigate the effect of acute exercise on circulating VEGF in adults.
Materials and Methods: In order to extract original articles, a comprehensive search was conducted in the databases of PubMed, Scopus, Web of Science, SID, Magiran and Google Scholar until 2023 March 1 for studies investigating the effects of acute exercise on circulating levels of VEGF. The meta-analysis criteria included studies published in Persian and English language journals, studies with human subjects with an average age of more than 18 years, studies investigating the effect of acute exercise, and studies measuring serum or plasma VEGF levels. To determine the effect size, standardized mean differences (SMD) values and 95% confidence intervals (CIs) were calculated using CMA2 software. The level of heterogeneity was assessed using the I2 test and the publication bias was also assessed with Egger's test.  Furthermore, subgroup analysis was performed for health status (with chronic disease and healthy) and type of exercise (aerobic, resistance and high-intensity interval exercise).
Results: In total, 27 articles (49 exercise interventions) including 704 subjects were included in the meta-analysis. The results of data analysis showed that acute exercise did not lead to significant changes in VEGF immediately after exercise compared to baseline [0.17, (CI: -0.05 to 0.40, p=0.14). The results of subgroup analysis based on the health status showed that exercise had no significant effect on VEGF in healthy subjects [SMD: 0.10, p=0.40], while it tended to increase VEGF in patients [SMD: 0.30, p=0.05]. The results of the subgroup analysis based on the type of exercise also showed that resistance exercise [SMD: 0.58, p=0.008] leads to a significant increase and high-intensity interval exercise [SMD: 0.29, p=0.06] leads to a non-significant increase in VEGF, while the effect of aerobic exercise [SMD: 0.009, p=0.95] was not significant.
Conclusion: In general, the findings of this meta-analysis showed that the type of exercise plays an effective role in the responses of VEGF to acute exercise. Resistance and high intensity interval exercise may lead to an increase in circulating VEGF immediately post exercise, while aerobic exercise does not have significant effects. In addition, exercise may increase VEGF in people with metabolic-cardiovascular disease, whereas, it is not effective in healthy individuals.
 

کلیدواژه‌ها [English]

  • Exercise
  • angiogenesis
  • VEGF

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سابقه مقاله

  • تاریخ دریافت: 03 مرداد 1402
  • تاریخ بازنگری: 16 شهریور 1402
  • تاریخ پذیرش: 26 شهریور 1402
  • تاریخ اولین انتشار: 28 شهریور 1402
  • تاریخ انتشار: 01 آذر 1402

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