تأثیر 8 هفته تمرین تناوبی با شدت بالا بر تجمع پلاکت و میزان فسفریلاسیون 239VASPser در مردان مبتلابه بیماری انسداد رگ های قلبی

نوع مقاله : علمی - پژوهشی

نویسندگان

1 دانشگاه ارومیه گروه فیزیولوژی ورزشی و حرکات اصلاحی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ایران

2 گروه علوم زیستی در ورزش و تندرستی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران

3 گروه علوم آزمایشگاهی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی کاشان، کاشان، ایران

چکیده

هدف: فعالیت به ویژه با شدت بالا، باعث افزایش فعالیت و تجمع پلاکت در بیماران قلبی میشود. هدف از انجام این تحقیق بررسی
تأثیر 8 هفته فعالیت تناوبی با شدت بالا بر فعالیت و تجمع و میزان فسفریلاسیون 239VASPser پلاکتی در مردان مبتلابه بیماری
قلبی- عروقی بود.
روش ها: بیست بیمار قلبی CABG و PCI که از زمان جراحی آنان کمتر از سه ماه گذشته بود، به صورت داوطلبانه انتخاب و به دو
گروه 10 نفرۀ کنترل و تمرین تناوبی تقسیم شدند. یک هفته پس از اندازه گیری مشخصات تن سنجی و تعیین اوج اکسیژن مصرفی،
آزمودنی ها به مدت 8 هفته و هفتهای 3 جلسه در تمرین های تناوبی شرکت کردند. هر جلسه شامل 40 دقیقه فعالیت بود. هفته
اول با شدت 75 به 15 شروع و هر دو هفته 5 % افزایش یافت. در دو هفته پایانی، شدت 90 به 30 درصد اوج اکسیژن مصرفی
رسید. گروه کنترل در طول دوره، فعالیت ورزشی نداشتند. نمونه های خونی قبل و 48 ساعت پس از آخرین جلسه تمرینی اخذ
شد. نمونه ها برای اندازه گیری تجمع پلاکتی، پی- سلکتین و فسفریلاسیون 239VASPser آنالیز شدند. آزمون تی وابسته و مستقل
برای تحلیل آماری داده ها استفاده شد.
نتایج: تجمع و پی- سلکتین پلاکتی گروه تمرین در پاسخ به ADP در مقایسه با گروه کنترل کاهش معنی داری داشت.
فسفریلاسیون 239VASPser در پاسخ به NO در گروه تمرین، افزایش معنی داری یافت ) 05 / 0
 
نتیجه گیری: هشت هفته تمرین تناوبی باعث بهبود عوامل فعالیت و مهار پلاکتی در بیماران قلبی گردید. احتمالاً تمرین های
منظم ورزشی با شدت بالا از طریق کاهش بیان CD62P و افزایش حساسیت به NO تولیدی در بافت پوششی رگ خونی، باعث
بهبود عملکرد پلاکت شود.

کلیدواژه‌ها

عنوان مقاله [English]

The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease

نویسندگان [English]

  • Akbar Nouri-habashi 1
  • Sajad Ahmadizad 2
  • Morteza Salimian 3
  • Hiwa Rahmani 2
1 Department of Exercise Physiology and Corrective Exercises, Faculty of Sports Sciences, Urmia University, Urmia, Iran
2 Department of Sport and Exercise Physiology, Faculty of Sports Sciences, Shahid Beheshti University, Tehran, Iran
3 Department of Medical Laboratory, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
چکیده [English]

Purpose: Exercises increase platelet activation and aggregation in patients with cardiovascular diseases especially at high intensities. The aim of the study was to investigate the effect of 8 weeks of high-intensity interval training on platelet activation and aggregation and phosphorylation of VASPser239 in the coronary heart patients.
Methods: For this purpose, twenty CABG and PCI patients (≤ 3 months) participated voluntarily and were randomly divided into two groups; i.e. control (N=10) and interval training (N=10) groups. Anthropometric characteristics and peak oxygen consumption were recorded a week before the start. High-intensity interval training group patients participated in an 8 weeks exercise training program, three times a week. The interval training program consisted of a warm-up, 8 reps/ four min (exercise: 2min, active recovery: 2min, intensity: 90/ 30) and finally, cool down. Each session lasted 40 min. The training intensity was started 75/ 15% of the peak oxygen consumption but gradually increased during the first two weeks to reach 90/ 30% of peak oxygen consumption in the last two weeks. The control group did not participate in regular exercises during this period. Blood samples were taken before and 48h after the last exercise session and analyzed for platelet aggregation, CD62p expression, and phosphorylation of VASPser239. The dependent and independent t-tests were used for statistical analysis.
Results: A significant difference was observed between the two groups in the amount of decrease in platelet aggregation and CD62p expression in response to ADP (P <0.05). Also, the VASP phosphorylation at ser239 was increased significantly in response to NO in the interval training group (P<0.05).
Conclusion: Eight weeks of high-intensity interval training led to the improvement in platelet activation and aggregation factors in coronary heart patients of this study. It seems that regular high-intensity exercise may improve platelet function, due to a decrease in CD62P expression and an increase in sensitivity to NO production by endothelial cells.

کلیدواژه‌ها [English]

  • High-intensity interval training
  • Platelet aggregation
  • P selectin
  • VASP phosphorylation

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سابقه مقاله

  • تاریخ دریافت: 13 دی 1395
  • تاریخ بازنگری: 28 مهر 1400
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 بهمن 1397

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