Aim: Cytokines are a group of proteins that play a central role in mediating inflammatory responses to
pathological stimuli such as infection and tissue damage.The goal of present research was to investigation
the effect of resistance training along with omega-3 fatty acid supplementation on resting levels of some
pro-inflammatory cytokine (TNF-α, IL-6) of older women. Methods: Subjects were whom 24 elderly
women (average age: 79.6 ± 4.2 years, height 151.7± 4.2 cm, weight 60.8±8.7kg, BMI 26.4±3.3kg/m²).
Subjects were chosen purposefully and randomly divided in to 3 groups of the first empirical group (n=8),
resistance training along with omega-3 fatty acid, the second empirical group (n=8) just resistance
training, and the third one (n=8) as a control group. The subjects participated in resistance training for 8
weeks, 3 sessions every week by 60-80% intensity with maximum repitation incloding foot press, chest
press, shoulder press, the front arm, triceps, sheet pool, hip flextion, hip extention, hip abduction .The
ferst empirical group recived 3gr of omega-3 fatty acid at a day within 8 weeks. Pro-inflammatory
cytokine was measured using blood sample and ELISA method after 8 hours of an empty stomach in the
amount of 3 c.c from interior vein of subjects arms befor and after 8 weeks of exercise. Results: Results
show Interleukin-6 and TNF-α have significant decrees after the test into empirical groups while there is
no significant in control group. Also, there is graet difference of IL-6 and TNF-α among 3 groups. Posthoc
test showed a mean difference in training and supplementation group is greater than training along
group. Conclusion: It seems resistance training along with omega-3 fatty acid supplementation. Can have
greater effect than training along on pro-inflammatory cytokine of older women decrees.