The effect of a session of moderate intensity aerobic exercise on inflammatory factors and flow-mediated dilation in pre-menopausal and post-menopausal women

Damirchi, Arsalan; Shiravi, Sanaz

doi:10.48308/joeppa.2024.234549.1224

The effect of a session of moderate intensity aerobic exercise on inflammatory factors and flow-mediated dilation in pre-menopausal and post-menopausal women

Document Type : original article

Authors

Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Guilan, Iran

10.48308/joeppa.2024.234549.1224

Abstract

Background and purpose: Cardiovascular diseases are the most important cause of death among women. Hormonal changes around and after menopause can affect inflammatory factors such as interleukins and tumor necrosis factor alpha (TNF-α) as well as vascular function. The aim of this research was to determine the effect of a session of aerobic exercise with moderate intensity on interleukins 6 and 8, TNF-α, as well as vascular function (flow mediated dilation) in premenopausal and postmenopausal women.
Materials and methods: In this semi-experimental study, 30 inactive women without any cardiovascular disease participated in the study voluntarily, which were allocated into two equal groups (n=15) of premenopausal women (age, 47.7±1.3 years) and postmenopausal women (age, 56.8±1.5 years). Participants in both groups performed a session of moderate intensity aerobic exercise included 30 min of running on a treadmill at 60-70% of heart rate reserve. Participants' blood samples were collected 30 min before and 30 min after the exercise and were analyzed to measure inflammatory factors (interleukin 6, interleukin 8 and TNF-α). Vascular function was evaluated by measuring flow mediated dilation at 15 min before and 15 min after aerobic exercise. Data were analyzed by using SPSS software and covariance test (P>0.05).
Results: In response to a session of moderate intensity aerobic exercise, no significant difference was seen in interleukin 6 and 8 between two groups of premenopausal and postmenopausal women (P=0.432, P=0.097), but TNF-α decreased significantly in premenopausal whereas it it did not change in postmenopausal women (P=0.003). In addition, vascular dilation after a session of moderate intensity aerobic exercise was significantly (P=0.001) different between premenopausal and postmenopausal women , where, flow mediated dilation increased in premenopausal compared to postmenopausal women.
Conclusion: Based on the increased FMD and decreased TNF-α in premenopausal women, in general our findings show that following acute exercise factors associated with endothelial responsiveness are improved in premenopausal women while responses are decreased in postmenopausal womenHowever, lack of differences in interleukins 6 and 8 between premenopausal and postmenopausal women might indicate increased inflammation in premenopausal women, which is a reason for the onset or increases in disorders of endothelial function during menopause.

Keywords

Main Subjects

cardiovascular and circulatory

References

1. El Hajj A, Wardy N, Haidar S, Bourgi D, Haddad ME, Cham- mas DE, et al. Menopausal symptoms, physical activity level and quality of life of women living in the Mediterranean region. PLoS One 2020; 15: e0230515.
2. Hamoda H, Moger S. Developing the Women's health strategy: The British Menopause Society's recommendations to the department of health and social care's call for evidence. Post Re- prod Health 2022; 28: 13-8.
3. Gebretatyos H, Ghirmai L, Amanuel S, Gebreyohannes G, Tsighe Z, Tesfamariam EH. Effect of health education on knowledge and attitude of menopause among middle-age teachers. BMC Womens Health 2020; 20: 232.
4. Moore, K.J.; Sheedy, F.J.; Fisher, E.A. Macrophages in atherosclerosis: A dynamic balance. Nat. Rev. Immunol. 2013, 13, 709–721.
5. Ait-Oufella, H.; Taleb, S.; Mallat, Z.; Tedgui, A. Recent advances on the role of cytokines in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2011, 31, 969–979.
6. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab. 2012a;97(12):4692–700.
7. Andrew Maiorana, Gerry Daniel J Green، O'Driscoll and Roger Taylor. Effect of Exercise training on endothelium derived nitric oxide function in humans. J Physiol. 2004 November 15; 561(Pt 1): 1–25.
8. Musa Khalafi, Pejman Taghibeikzadehbadr, Eisa Naebi Alamdari. The comparison the effect of resistance training versus aerobic training on endothelial function in adults: a systematic review and meta-analysis. JAHSSP.2023.28623.1554. (In Persia)
9. Lansford KA, Shill DD, Dicks AB, Marshburn MP, Southern WM, Jenkins NT. Effect of acute exercise on circulating cell and microparticle populations. Exp Physiol. 2016, 101:155–167.
10. Durrer C, Robinson E, Wan Z, Martinez N, Hummel ML, Jenkins NT, Kilpatrick M, Little JP. Differential impact of acute high-intensity exercise on circulating endothelial microparticles and insulin resistance between overweight/obese males and females. PLoS One. 2015, 10: e0115860.
11. Corinna Serviente, Lisa M. Troy, Maxine de Jonge, Daniel D. Shill, Nathan T. Jenkins, and Sarah Witkowski. Endothelial and inflammatory responses to acute exercise in perimenopausal and late postmenopausal women. Am J Physiol Regul Integr Comp Physiol. 2016, 311: R841–R850.
12. Moreau KL, Deane KD, Meditz AL, Kohrt WM. Tumor necrosis factor-􏰂 inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Atherosclerosis. 2018, 230: 390–396.
13. Tani A, Yasui T, Matsui S, Kato T, Kunimi K, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M. Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition. Cytokine. 2017, 62: 86–90.
14. Mohammad Kazemipour, Hasan Matinhomaee, Parvin Farzanegi. The effect of aerobic exercise with pistachio skin extract on the expression of IL-6, IL-1 and TNF-α in heart tissue of obese rats. Journal of Sport and Exercise Physiology Winter 2023/Vol.15/No.4/93-102. (In Persia)
15. Mittermayer F, Pleiner J, Schaller G, et al. Tetrahydro-biopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction. The American Journal of Physiology: Heart and Circulatory Physiology. 2015; 289(4):H1752–H1757.
16. Madge LA, Pober JS. TNF signaling in vascular endothelial cells. Experimental and Molecular Pathology. 2011; 70(3):317–325.
17. Geleeson, M.(2007).“Immune function in sport and exercise. ”. J Appl Physiol (1985). Aug;103(2)PP:693-9.
18. Muller, M., Liesen, H., Kirchner, H.“ Moderate and exhaustive endurance exercise influencesthe interferon-gamma levels in whole–blood culture supernatants”. Eur J Appl Physiol, 2017, 76:PP: 165-9.
19. Simona, Armstrong SJ “ Diet or exercise: what is more effective in preventing or reducing metabolic alterations?”, European Journal of Endocrinology, 2018, 159:PP: 685–691.
20. Moreau KL, Deane KD, Meditz AL, Kohrt WM. Tumor necrosis factor-􏰂 inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Atherosclerosis. 2013, 230: 390–396.
21. Sivro A, Lajoie J, Kimani J, Jaoko W, Plummer FA, Fowke K, Ball TB. Age and menopause affect the expression of specific cytokines/ chemokines in plasma and cervical lavage samples from female sex workers in Nairobi, Kenya. Immun Ageing. 2013, 10: 42.
22. Scott JP, Sale C, Greeves JP, Casey A, Dutton J, Fraser WD. Effect of exercise intensity on the cytokine response to an acute bout of running. Med Sci Sports Exerc. 2019, 43: 2297–2306.
23. Dorneles GP, Haddad DO, Fagundes VO, Vargas BK, Kloecker A, Romão PR, Peres A. High intensity interval exercise decreases IL-8 and enhances the immunomodulatory cytokine interleukin-10 in lean and overweight-obese individuals. Cytokine. 2016, 77: 1–9.
24. Musa Khalafi, Pejman Taghibeikzadehbadr, Behzad Aria, Zahra Mohammadi, The effect of resistance training on endothelial function in young and older with chronic diseases and those with health conditions: a systematic review and meta-analysis. Journal of Sport and Exercise Physiology 2023/Vol.16/No.2/105-120. (In Persia)
25. Moreau KL, Stauffer BL, Kohrt WM, Seals DR. Essential role of estrogen for improvements in vascular endothelial function with endur- ance exercise in postmenopausal women. J Clin Endocrinol Metab. 2018, 98: 4507–4515.
26. Swift DL, Weltman JY, Patrie JT, Saliba SA, Gaesser GA, Barrett EJ, Weltman A. Predictors of improvement in endothelial function after exercise training in a diverse sample of postmenopausal women. J Womens Health. 2013, 23: 260–266.
27. Hallmark R, Patrie J T, Liu Z, Gaesser G A, Barrett E J, Weltman A. The effect of exercise intensity on endothelial function in physically inactive lean and obese adult. PLoS One. 2014; 9(1): 85450.
28. Franklin NC, Ali M, Goslawski M, Wang E, Phillips SA. Reduced vasodilator function following acute resistance exercise in obese women. Front Physiol 5: 253, 2014.
29. Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol. 2011, 300: H2–H12.