The effect of different Intensities of circuit resistance training on plasma neuregulin and leptin concentrations in young men

Document Type : original article

Authors

1 Exercise Biochemistry Division, Faculty of Sports Sciences, University of Mazandaran, Baboulsar, Mazandaran, Iran

2 Department of Sports Science, School of Literature and Humanities, Ilam University, Ilam, Iran

Abstract

Purpose: The purpose of this study was to investigate the effect of different Intensities of circuit resistance training on plasma neuregulin and leptin concentrations in young men.
Methods: Forty-five healthy young men [21.55± 0.17 years old; height= 175.42± 0.88 cm, weight= 73.10±
1.63 Kg] were randomly divided into 5 groups (control, 20, 40, 60 and 80% 1RM). Men of training groups performed circuit resistance training 4 times a week with given intensities for 6 weeks. The blood sampling was conducted to determine the levels of neuregulin-1, leptin, insulin, and glucose before, and after 6 weeks. Data were analyzed using the analysis of covariance and paired T-test.
Results: The plasma neuregulin-1 (P= 0.0001), leptin (P= 0.009), and insulin (P=0.013) levels were significantly increased in the training groups compared with the control group while there were no significant differences between the glucose (P=0.27) level of groups.
Conclusion: The results showed circular resistance training plays a significant role in promoting the performance of NRG-1 and leptin.

Keywords

References

  1. Odiete O, Hill MF, Sawyer DB. Neuregulin in cardiovascular development and disease. Circulation research. 2012; 111(10): 1376-85.
  2. Lebrasseur NK, Coté GM, Miller TA, Fielding RA, Sawyer DB. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. American Journal of Physiology-Cell Physiology. 2003; 284(5): C1149-C55.
  3. Ghanbari-Niaki A. Neuregulins Response to Exercise: a Mini Review. Annals of Applied Sport Science. 2016; 4(1): 3-7.
  4. Ennequin G, Boisseau N, Caillaud K, Chavanelle V, Etienne M, Li X, et al. Neuregulin 1 Improves Glucose Tolerance in db/db Mice. PloS one. 2015; 10(7): e0130568.
  5. Cantó C, Pich S, Paz JC, Sanches R, Martínez V, Orpinell M, et al. Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells. Diabetes. 2007; 56(9): 2185-93.
  6. Cantó C, Suárez E, Lizcano JM, Griñó E, Shepherd PR, Fryer LG, et al. Neuregulin signaling on glucose transport in muscle cells. Journal of Biological Chemistry. 2004; 279(13): 12260-8.
  7. Gumà A, Martínez-Redondo V, López-Soldado I, Cantó C, Zorzano A. Emerging role of neuregulin as a modulator of muscle metabolism. American Journal of Physiology-Endocrinology And Metabolism. 2010; 298(4): E742-E50.
  8. Ennequin G, Boisseau N, Caillaud K, Chavanelle V, Gerbaix M, Metz L, et al. Exercise training and return to a well‐balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats. The Journal of physiology. 2015; 593(12): 2665-77.
  9. Cha Y, Kang Y, Moon A. HER2 induces expression of leptin in human breast epithelial cells. BMB reports. 2012; 45(12): 719.
  10. Cantó C, Chibalin AV, Barnes BR, Glund S, Suárez E, Ryder JW, et al. Neuregulins mediate calcium-induced glucose transport during muscle contraction. Journal of Biological Chemistry. 2006; 281(31): 21690-7.
  11. LeBrasseur NK, Mizer KC, Parkington JD, Sawyer DB, Fielding RA. The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training. European journal of applied physiology. 2005; 94(4): 371-5.
  12. WANG Q-a, CAI M-x, TIAN Z-j. Effects of Resistance Training on NRG1 Express of Heart and Skeletal Muscle in Different Gender Rats with Myocardial Infarction. Journal of Beijing Sport University. 2014; 11: 012.
  13. Emilsson V, Liu Y-L, Cawthorne MA, Morton NM, Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes. 1997; 46(2): 313-6.
  14. Fisher JS, Van Pelt RE, Zinder O, Landt M, Kohrt WM. Acute exercise effect on postabsorptive serum leptin. Journal of Applied Physiology. 2001; 91(2): 680-6.
  15. Lau PW, Kong Z, Choi C-r, Clare C, Chan DF, Sung RY, et al. Effects of short-term resistance training on serum leptin levels in obese adolescents. Journal of Exercise Science & Fitness. 2010; 8(1): 54-60.
  16. Alcaraz PE, Sánchez-Lorente J, Blazevich AJ. Physical performance and cardiovascular responses to an acute bout of heavy resistance circuit training versus traditional strength training. The Journal of Strength & Conditioning Research. 2008; 22(3): 667-71.
  17. Pichon CE, Hunter GR, Morris M, Bond RL, Metz J. Blood Pressure and Heart Rate Response and Metabolic Cost of Circuit Versus Traditional Weight Training. The Journal of Strength & Conditioning Research. 1996; 10(3): 153-6.
  18. Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE. Effect of the volume and intensity of exercise training on insulinsensitivity. Journal of Applied Physiology. 2004; 96(1): 101-6.
  19. Ghanbari Niaki A, Ardeshiri S, AliakbariBaydokhty M, Saeidi A. Effects of Circuit Resistance Training with Crocus sativus Supplementation on Insulin and Estradiol Hormones Response. Quarterly of Horizon of Medical Sciences. 2016; 22(2): 125-30.
  20. Ennequin G, Boisseau N, Caillaud K, Chavanelle V, Etienne M, Li X, et al. Neuregulin 1 affects leptin levels, food intake and weight gain in normal-weight, but not obese, db/db mice. Diabetes & metabolism. 2015; 41(2): 168-72.
  21. Horiuchi K, Zhou H-M, Kelly K, Manova K, Blobel CP. Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins β1 and β2. Developmental biology. 2005; 283(2): 459-71.
  22. Moondra V, Sarma S, Buxton T, Safa R, Cote G, Storer T, et al. Serum neuregulin-1β as a biomarker of cardiovascular fitness. The open biomarkers journal. 2009; 2: 1.
  23. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995; 269(5223): 543-6.
  24. Lee M-J, Fried SK. Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. American Journal of Physiology-Endocrinology And Metabolism. 2009; 296(6): E1230-E8.
  25. Rogers C, Moukdar F, McGee MA, Davis B, Buehrer BM, Daniel KW, et al. EGF receptor (ERBB1) abundance in adipose tissue is reduced in insulin-resistant and type 2 diabetic women. The Journal of Clinical Endocrinology & Metabolism. 2012; 97(3): E329-E40.
  26. Snodgrass-Belt P, Gilbert JL, Davis FC. Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters. Brain research. 2005; 1038(2): 171-82.
  27. Ennequin G, Capel F, Caillaud K, Chavanelle V, Etienne M, Teixeira A, et al. Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice. Scientific Reports. 2017; 7.
  28. Choi Y-H, Li C, Hartzell DL, Little DE, Della-Fera MA, Baile CA. ICV leptin effects on spontaneous physical activity and feeding behavior in rats. Behavioural brain research. 2008; 188(1): 100-8.
  29. Boudou P, Sobngwi E, Mauvais-Jarvis F, Vexiau P, Gautier J. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. European journal of endocrinology. 2003; 149(5): 421-4.
  30. Pullinen T, Nicol C, MacDonald E, Komi PV. Plasma catecholamine responses to four resistance exercise tests in men and women. European journal of applied physiology and occupational physiology. 1999; 80(2): 125-31.

Files

History

  • Receive Date: 11 February 2018
  • Revise Date: 13 October 2021
  • Accept Date: 31 December 2020
  • First Publish Date: 31 December 2020
  • Publish Date: 21 January 2019

Share

How to cite

Statistics