Effect of eight weeks continues and HIIT exercises on VEGF-A and VEGFR-2 levels in stratum, hippocampus and cortex of wistar rat brain

Document Type : original article

Abstract



The purpose of this study was to investigate the effect of eight week continues and HIIT exercise on VEGF-A
and VEGFR-2 levels in stratum, hippocampus and cortex of wistar rat brain. Methods: for this purpose, 24
wistar rats (age: 9 weeks, weight: 200±20gr) were selected. After one week of familiarization with laboratory
environment, they were randomly divided into three groups consisted of: control, continuous training and high
intensity interval training. They did continuous and high-intensity interval training for eight-weeks. Twentyfour
hours after last section of exercise they sacrificed and sampling of stratum, hippocampus and cortex were
performed. Then, for assessment of VEGF-A and VEGFR-2 level, western blot method was used and for
statistical analysis of the data's, the one-way ANOVA was used. Data of this study illustrated that VEGF-A
protein in the stratum in HIIT and in hippocampus, the continuous training and in the cortex HIIT group was
higher than the control group (P< 0/..5). Also VEGFR2 protein in the stratum and hippocampus area in both
groups were higher than control group. While this difference was not significant in cortex. The results showed
that both continuous and high-intensity interval training can increase the amount of VEGF-A and VEGFR2
proteins. Thus HIIT because of the time advantage can

Keywords

References

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Journal of Sport and Exercise Physiology
Volume 8, Issue 2 - Serial Number 16
September 2015
Pages 1213-1221

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History

  • Receive Date: 19 June 2016
  • Revise Date: 11 June 2024
  • Accept Date: 31 December 2020
  • First Publish Date: 31 December 2020
  • Publish Date: 22 November 2015

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