Response of cortisol TNF- α, and plasma lactate levels, to the coenzyme Q10 during exercise at a constant intensity in active females

doi:10.48308/joeppa.2016.98773

Response of cortisol TNF- α, and plasma lactate levels, to the coenzyme Q10 during exercise at a constant intensity in active females

Document Type : original article

10.48308/joeppa.2016.98773

Abstract

Purpose: The purpose of this study was to investigate the response of cortisol levels, TNF-α and plasma
lactate to acute Q10 supplementation during constant load exercise in active females. Methods: 24 subjects
were randomly assigned to supplementation and placebo groups. Supplement containing 2 mg per kg of body
weight, coenzyme Q10, which was dissolved in 250 ml water. Placebo also contained water with food colour.
Supplement and placebo consumed 120 min before the exercise test. Before and immediately after the test
blood samples were collected. Data were analysed using the t test. Results: The results showed no significant
differences between the rest and after exercise in the value of cortisol levels, TNF-α and lactate (p>.05).
Conclusion: According to the results of this study and not positive effects of this supplement on the lactate
and immune system, it seems that there is no need for the use of this supplement in active people.

Keywords

References

مسعود احمد، ثابتی خشایار، (1382). ایمونولوژی ورزشی، نشر اکنون. چاپ اول.
Bishop NC. (2006). Exercise and infection risk. In Gleeson M (Ed.) Immune‌‌ functions in sport and exercise. Churchill Liv.
Peters EM, Goetzsche JM, Joseph LE, Noakes TD. (1996). Vitamin C as effective as combinations of anti-oxidant nutrients in reducing symptoms of upper respiratory tract infections in ultra marathon runners. S Afr Sports Med. 11:23–27.
Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, Sjoberg LB, Pedersen BK. (2004). Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiology 558:633–645.
Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. (2006). Recent advance in the relationship between obesity, inflammation, and insulin resistance. Euro Cytokine Netw; 17(1):4–12.
Robson, P. J., Boric, P. J. D., & Myburgh, K. H. (2003).Antioxidant supplementation enhances neutrophil oxidative burst in trained runners following prolonged exercise. International Journal of Sport Nutrition and Exercise Metabolism, 13,369_381.
Bhagavan HN, Chopra RK. (2006). Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 40:445–453.
Hoffman. Goetz and Pederson B. K. (1994). Exercise and the immune system: A model of the stress Immunoresponse .Today, 15:345-392.
Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K & Kitahara M. (2007). Study on safety and bioavailability of ubiquinol (KanekaQH) after single and 4-week multiple oral administrations to healthy volunteers. Regul Toxicol Pharmacol 47, 19–28.
Banerjee AK, Mandal A, Chanda D & Chakraborti S. (2003). Oxidant, antioxidant and physical exercise. Mol Cell Biochem 253, 307–312.
Matthew Cooke et al. (2008). Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. Journal of the International Society of Sports Nutrition, 5:8
Tauler P , Miguel D. F , Sureda A , Pujol P , Drobnic F, Josep A. Pons T.A. (2008). Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer. Euro J Appl Physiol 104:777–785
Bengt Östman, Anders Sjödin C, Karl Michaëlsson DE, Liisa Byberg (2012). Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans. Nutrition 28: 403–417.
Weber C, Bysted A & Holmer G. (1996). the coenzyme Q10 content of the average Danish diet. Int J Vitam Res 67, 123–129.
Vassilakopoulos T, Karatza M, Katsaounou P, Kollintza A, Zakynthinos S, and Roussos C. (2003). Antioxidants attenuate the plasma cytokine response to exercise in humans. J Appl Physiol 94: 1025–1032
Kumar CT, Reddy VK, Prasad M, Thyagaraju K & Reddanna P. (1992). Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Mol Cell Biochem 111, 109–115.
Nieman DC, Nehlson C.SL, Markoff PA, Balk L.AJ, Yang H, Chritton DB, Lee JW, Arabatzis K. (1990). the effect of moderately exercise training of natural killer cells and acute upper respiratory tract infections. Int. J. Sport. Med; 11(6):467-73.7-
Mastaloudis A, Morrow JD, Hopkins DW, Devaraj S & Traber MG. (2004). Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inﬂammation, in ultramara-thon runners. Free Radic Biol Med 36, 1329–1341.
Neiman, David. C., L.S. Berk, M. Simpson-Westerberg, K. Arabatzis, S. Youngberg, S.A. Tan, J.W. Lee, and W.C. Eby. (1998). Effect of long-endurance running on immune system parameters and lymphocyte function in experienced marathoners Int. J. Sport. Med; 10:317-323.
Nieman DC. (1994). Effect of high- versus moderate- intensity Int J. sports med. vol. 15: 199-206,
Antuna P.B et al. (2007). Adipokines: The missing link between insulin resistance and obesity. Diabetes &Metabolism Volume 34, Issue 1, Pages 2-11
Nieman DC, Henson DA, Butterworth DE, Warren BJ, Davis JM, Fagoaga OR and Nehlsen-Cannarella SL. (1997). Vitamin C supplementation does not alter the immune response to 2.5 hours of running. Int J Sport Nutr 7(3):173–184.
Kaltschmidt B, Sparna T, Kaltschmidt C. (1999). Activation of NFKB by reactive oxygen intermediates in the nervous system. Antioxi Redox Signal 1:129–144
Strieter, R., Kunkel, S., Bone, R. (1993). Role of Tumour Necrosis Factor-Alpha in Disease States and Inflammation. Critical Care Medicine. 21 (10 Supplement): S447-S463.
Rink, L., Kirchner, H. (1996). Recent Progress in the Tumor Necrosis Factor-Alpha Field. International Archives of Allergy and Immunology. 111 (3): 199-209.
Pedersen, B.K., Steensberg, A., Fischer, C., Keller, C., Keller, P., Plomgaard, P., Febbraio, M. and Saltin, B. (2003). Searching for the exercise factor: is IL-6 a candidate? Journal of Muscle Research Cell Motility 24, 113-119.
Kandere G.K., Letourneau R., Boucher W., Bery J., Kempuraj D., Poplawski S., Athanassiou A., and Theoharides T.C. (2003). IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J. Immunology; 171:4830–4836.
Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, Okamoto T, Kono I. (2008). Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr; 100(4):903-9.
Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. (2008). Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition; 24(4):293-9.