The effect of Aerobic training on Klotho-FGF23 axis and arterial calcification in type 2 diabetic Postmenopausal women

Document Type : original article

Authors

Faculty of Physical Education and Sports Sciences, Kharazmi University, Tehran, Iran

Abstract

Purpose: Although exercise is one of the Medical aid strategies to reduce arterial stiffness in diabetic patients, but the mechanism remains unclear. The purpose of this study was to determine the effect of aerobic exercise on Klotho-fibroblast growth factor-23 (FGF23) axis and arterial calcification in type 2 diabetic Postmenopausal women.
Methods: Twenty-four type-2 diabetic Postmenopausal women who were registered at the diabetes association of Shahrood, randomly assigned into two groups including exercise (n=12, 51±6 yrs, 31.9±5 kg/m2) and control (n=12, 52±5 yrs, 29.23.8 kg/m2). The aerobic training consisted of 45 to 60 minutes running with 45 to 70 percent of heart rate reserve, three sessions per week for 8 weeks. Before and after the experimental period, blood fasting samples were taken and the ELISA method was used to analyzed klotho and FGF23. Arterial stiffness analysis was also performed using VaSera-VS-2000. The data were analyzed using the statistical tests of Paired and Independent t-test (P0.05). But, that calcium levels in exercise group decreased significantly following the experimental period (P

Keywords

References

  1. Nathan DM. Long-term complications of diabetes mellitus. New England Journal of Medicine. 1993;328(23):1676-85.
  2. Gale EA, Gillespie KM. Diabetes and gender. Diabetologia. 2001;44(1):3-15.
  3. Moosavi J, Habibian M, Farzanegi P. The effect of regular aerobic exercise on plasma levels of 25- hydroxy Vitamin D and insulin resistance in hypertensive postmenopausal women with type 2 diabetes. RJMS. 2016;22:80–90.
  4. Matsubara T, Miyaki A, Akazawa N, Choi Y, Ra SG, Tanahashi K, Kumagai H, Oikawa S, Maeda S. Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women. American Journal of Physiology-Heart and Circulatory Physiology. 2014 Feb 1;306(3):H348-55.
  5. Fakhrzadeh H, Sharifi F. Pre-clinical atherosclerosis, a review article. Iran Journal of Diabetes and Metabolis. 2017 Jan 15;10(2):117-29.‎
  6. Hassanzade S, Raz A, Mansouri M, Mirzaeezadeh Z, Larijani B. ASSESSMENT OF THE RELATIONSHIP BETWEEN (THR399ILE) POLYMORPHISM OF TLR4 GENE WITH DIABETIC FOOT ULCER IN TYPE 2 DIABETIC PATIENTS REFERRED TO THE CLINIC OF DIABETES & METABOLIC DISEASES. Iranian Journal of Diabetes and Metabolism. 2017 Aug 15;16(1):9-16.
  7. ARAZI H, AFKHAMI M. Effects of acute resistance exercise on blood pressure and pain threshold in type 2 diabetic overweight patients. 2013, [Persian].
  8. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000 Sep 19;102(12):1351-7.
  9. Llaurado G, Ceperuelo-Mallafre V, Vilardell C, Simo R, Albert L, Berlanga E, Vendrell J, Gonzalez-Clemente JM. Impaired endothelial function is not associated with arterial stiffness in adults with type 1 diabetes. Diabetes & metabolism. 2013 Sep 1;39(4):355-62.
  10. Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D, Hsiao LL. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation. 2012 May 8;125(18):2243-55.
  11. Kuro-o M. Klotho and βKlotho. InEndocrine FGFs and Klothos 2012 (pp. 25-40). Springer US.
  12. Kuro-o M. The FGF23 and Klotho system beyond mineral metabolism. Clinical and Experimental Nephrology. 2016 Nov 12:1-6.
  13. Saghiv M, Sherve C, Ben-Sira D, Sagiv M, Goldhammer E. Aerobic Training Effect on Blood S-Klotho Levels in Coronary Artery Disease Patients. Journal of Clinical & Experimental Cardiology. 2016;7:1-4.
  14. Xiao NM, Zhang YM, Zheng Q, Gu J. Klotho is a serum factor related to human aging. Chinese medical journal. 2004 May;117(5):742-7at different intensities and volumes. Physical Education and Sport. v. 7, n. 2: 171-179; 2009.
  15. Atkinson J. Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences. Journal of applied physiology. 2008 Nov 1;105(5):1643-51.
  16. Hu MC, Shi M, Zhang J, Quiñones H, Griffith C, Kuro-o M, Moe OW. Klotho deficiency causes vascular calcification in chronic kidney disease. Journal of the American Society of Nephrology. 2011 Jan 1;22(1):124-36.
  17. Kitagawa M, Sugiyama H, Morinaga H, Inoue T, Takiue K, Ogawa A, Yamanari T, Kikumoto Y, Uchida HA, Kitamura S, Maeshima Y. A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PloS one. 2013 Feb 19;8(2):e56695.
  18. Ding HY, Ma HX. Significant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular disease. Journal of geriatric cardiology: JGC. 2015 Jul;12(4):439.17. Raglin, JS, Turner PE, Eksten F. State anxiety and blood pressure following 30 min of leg ergometry or weight training. Med Sci Sports Exerc. 25(9): 1044-1048; 1993.
  19. Avin KG, Coen PM, Huang W, Stolz DB, Sowa GA, Dube JJ, Goodpaster BH, O'Doherty RM,
  20. Ambrosio F. Skeletal muscle as a regulator of the longevity protein, Klotho. Frontiers in physiology. 2014 Jun 17;5:189.
  21. Fakhrpour R, Ebrahim Kh, Ahmadizad S, Tayebi Khoroshahi H. Effects of Combined Training on FGF23 and Some Vascular Calcification Risk Factors in Hemodialysis Patients. Med J Tabriz Uni Med Sciences Health Services. 2016;38(3):84-91.
  22. Seneli RM, Ebersole KT, O'Connor KM, Snyder AC. Estimated V [Combining Dot Above] O2max From the Rockport Walk Test on a Nonmotorized Curved Treadmill. The Journal of Strength & Conditioning Research. 2013;27(12):3495-505.
  23. Mitsumura H, Sakuta K, Bono K, Yamazaki M, Sengoku R, Kono Y, Kamiyama T, Suzuki M, Furuhata H, Iguchi Y. Stiffness parameter β of cardioembolism measured by carotid ultrasound was lower than other stroke subtypes. Journal of Stroke and Cerebrovascular Diseases. 2014 Jul 1;23(6):1391-5.
  24. Hayashi K, Yamamoto T, Takahara A, Shirai K. Clinical assessment of arterial stiffness with cardio-ankle vascular index: theory and applications. Journal of Hypertension. 2015;33(9):1742-57.
  25. Izuhara M, Shioji K, Kadota S, Baba O, Takeuchi Y, Uegaito T, et al. Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis. Circulation Journal. 2008;72(11):1762-7.
  26. Nagayama D, Watanabe Y, Saiki A, Shirai K, Tatsuno I. Lipid Parameters are Independently Associated with Cardio–Ankle Vascular Index (CAVI) in Healthy Japanese Subjects. Journal of atherosclerosis and thrombosis. 2018 Jan 12:42291.
  27. Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, Rucker J, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. Journal of Diabetes and its Complications. 2012;26(5):424-9.
  28. Medicine ACoS. ACSM's guidelines for exercise testing and prescription: Lippincott Williams & Wilkins; 2013.
  29. SHAVANDI N., SAREMI A., GHORBANI A., PARASTESH M. EFFECTS OF AEROBIC TRAINING ON RESISTIN, ADIPONECTIN AND INSULIN RESISTANCE INDEX IN TYPE 2 DIABETIC MEN. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) SUMMER 2011; 3 (10): 89-102.
  30. Donley DA, Fournier SB, Reger BL, DeVallance E, Bonner DE, Olfert IM, et al. Aerobic exercise training reduces arterial stiffness in metabolic syndrome. Journal of Applied Physiology. 2014;116(11):1396-404.
  31. Mostafidi E, Moeen A, Nasri H, Hagjo AG, Ardalan M. Serum Klotho Levels in Trained Athletes. Nephro-urology monthly. 2016 Jan;8(1).
  32. Nathan D, Turgeon H, Regan S. Relationship between glycated haemoglobin levels and mean glucose levels over time. Diabetologia. 2007;50(11):2239-44.
  33. Martin A, David V, Quarles LD. Regulation and function of the FGF23/klotho endocrine pathways. Physiological Reviews. 2012 Jan 1;92(1):131-55.
  34. Kizilgul M, Kan S, Beysel S, Apaydin M, Ozcelik O, Caliskan M, Ozbek M, Ozdemir S, Cakal E. Is fibroblast growth factor 23 a new cardiovascular risk marker in gestational diabetes?. Archives of Endocrinology and Metabolism. 2017(AHEAD):0-.
  35. Shirinzadeh M, Shakerhoseini R, Navaee L, Hoshyar rad A, Saadat N, Golestan B. Assessment of Vitamin D Supplementation Effect on Insulin Resistance among Type 2 Diabetic Patients. Iranian Journal of Nutrition Sciences & Food Technology. 2008; 15;1(2):1-6
  36. Su H, Peng J, Zhou J, Ying L, Jia W, Hu X, Ma X, Pan X, He X, Bao Y. Elevated serum fibroblast growth factor 23 levels as an indicator of lower extremity atherosclerotic disease in Chinese patients with type 2 diabetes mellitus. Cardiovascular diabetology. 2017 Dec;16(1):77.
  37. Razzaque MS. FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player? American Journal of Physiology-Renal Physiology. 2009 Mar 1;296(3):F470-6.
  38. Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D, Hsiao LL. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation. 2012 May 8;125(18):2243-55.

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History

  • Receive Date: 19 February 2018
  • Revise Date: 07 February 2021
  • Accept Date: 31 December 2020
  • First Publish Date: 31 December 2020
  • Publish Date: 22 August 2020

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