The effect of eight weeks of resistance training on adropin plasma level and insulin resistance index in overweight men

Document Type : original article

Authors

1 Department of Sports Science, North Tehran branch, Islamic Azad University, Tehran, Iran

2 Department of Sports Science, School of Literature and Humanities, Ilam University, Ilam, Iran

Abstract

Purpose: Adropin  a secreted protein is encoded by a gene Energy Homeostasis Associated (Enho) expressed in different tissues. The purpose of this study was to investigate the effect of eight weeks of resistance training on adropin plasma level and insulin resistance index in overweight men.
Methods: For this purpose, 24 volunteer overweight men (age 25.3 ± 5.1, body mass index 27.74 ± 2.54) were randomly divided into two groups of training and control. The training group held a resistance program for eight weeks, three sessions in each. The resistance program included three sets of 10 repetitions with 65, 75 and 85% 1RM for eight movements. One minute rest time was considered between sets and movements. Before and after the training period, the interested indices were measured by standard methods.
Results: ANOVA with Repeated measure test showed that there was a significant difference between the changes in adropin, glucose, insulin and insulin resistance (P = 0.001), also showed that adropin, glucose, insulin and insulin resistance (P = 0.001) are significant only in the training group.
Conclusion: It seems that this kind of resistance training has been able to stimulate adropin due to the sufficient duration and intensity of the activity.

Keywords

References

  1. Aydin, S., Three new players in energy regulation: preptin, adropin and irisin. Peptides, 2014. 56: p. 94-110.
    2. Kumar, K.G., et al., Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell metabolism, 2008. 8(6): p. 468-481.
    3. Aydin, S., et al., Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes. Molecular and cellular biochemistry, 2013. 380(1-2): p. 73-81.
    4. Gao, S., et al., Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin. Diabetes, 2014: p. DB_140388.
    5. Butler, A.A., et al., Low circulating adropin concentrations with obesity and aging correlate withrisk factors for metabolic disease and increase after gastric bypass surgery in humans. The Journal of Clinical Endocrinology & Metabolism, 2012. 97(10): p. 3783-3791.

6. Ganesh-Kumar, K., et al., Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity, 2012. 20(7): p. 1394-1402.
7. Goodyear, L.J. and B.B. Kahn, Exercise, glucose transport, and insulin sensitivity. Annual review of medicine, 1998. 49(1): p. 235-261.
8. Fujie, S., et al., Association between aerobic exercise training effects of serum adropin level, arterial stiffness, and adiposity in obese elderly adults. Applied Physiology, Nutrition, and Metabolism, 2016. 42(1): p. 8-14.
9. Soori, R., et al., Effect of aerobic exercise and caloric restriction on serum chemerin levels and insulin resistance index in women with type 2 diabetes. Iranian Journal of Diabetes and Metabolism, 2017. 16(2): p. 111-120.
10. Sanchis-Gomar, F., et al., Adropin and apelin fluctuations throughout a season in professional soccer players: Are they related with performance? Peptides, 2015. 70: p. 32-36.
11. Sato, K., et al., Acute bout of exercise induced prolonged muscle glucose transporter-4 translocation and delayed counter-regulatory hormone response in type 1 diabetes. PloS one, 2017. 12(6): p. e0178505.
12. WANG, Q.-a., M.-x. CAI, and Z.-j. TIAN, Effects of Resistance Training on NRG1 Express of Heart and Skeletal Muscle in Different Gender Rats with Myocardial Infarction. Journal of Beijing Sport University, 2014. 11: p. 012.
13. Eves, N.D. and R.C. Plotnikoff, Resistance training and type 2 diabetes. Diabetes care, 2006. 29(8): p. 1933-1941.
14. Irvine, C. and N.F. Taylor, Progressive resistance exercise improves glycaemic control in people with type 2 diabetes mellitus: a systematic review. Australian Journal of Physiotherapy, 2009. 55(4): p. 237-246.
15. Cooke, W.H. and J.R. Carter, Strength training does not affect vagal–cardiac control or cardiovagal baroreflex sensitivity in young healthy subjects. European journal of applied physiology, 2005. 93(5-6): p. 719-725.
16. soori, R., et al., Effect of endurance training on serum Apelin levels, C-reactive protein and insulin resistance index in middle-aged sedentary men. EBNESINA- Journal of Medical, 2017. 19(3): p. 32-40.
17. Kraemer, W.J. and N.A. Ratamess, Fundamentals of resistance training: progression and exercise prescription. Medicine and science in sports and exercise, 2004. 36(4): p. 674-688.
18. Matthews, D., et al., Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985. 28(7): p. 412-419.
19. Fujie, S., et al., Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults. American Journal of Physiology-Heart and Circulatory Physiology, 2015. 309(10): p. H1642-H1647.
20. Yosaee, S., et al., Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects. American journal of men’s health, 2017. 11(2): p. 426-434.
21. Eriksen, L., et al., Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus. Diabetologia, 2007. 50(11): p. 2245-2253.
22. Praet, S.F. and L.J. Van Loon, Optimizing the therapeutic benefits of exercise in type 2 diabetes. Journal of Applied Physiology, 2007. 103(4): p. 1113-1120.
23. Dela, F., et al., Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM. Diabetes, 1994. 43(7): p. 862-5.
24. Ebeling, P., et al., Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. J Clin Invest, 1993. 92(4): p. 1623-31.
25. Ivy, J.L., Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports Med, 1997. 24(5): p. 321-36.

26. Andersson, A., et al., Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle. Am J Physiol, 1998. 274(3 Pt 1): p. E432-8.
27. Kriketos, A.D., et al., Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care, 2004. 27(2): p. 629-30.
28. Hulver, M.W. and J.A. Houmard, Plasma leptin and exercise: recent findings. Sports Med, 2003. 33(7): p. 473-82.

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History

  • Receive Date: 28 August 2018
  • Accept Date: 07 June 2020
  • First Publish Date: 22 June 2021
  • Publish Date: 22 June 2021

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