Effect of Selected Combined Training Program on leptin serum levels of men with multiple sclerosis

The purpose of this study was to determine the effect of eight weeks combined training on leptin serum
levels in men with multiple sclerosis (MS). Twenty men with MS age 34.45±3.75 yrs, mean Expanded
Disability Status Scale 1.80±0.65, weight 71.95±7.45 Kg and body mass index 24.78±2.01 Kg/m2, were
randomly divided to subgroup, experimental (n=10) and control (n=10) groups. The experimental group,
beside consuming the prescribed drugs, participated in eight weeks combined training (include warming
for 20 minutes, aerobic training for 15 minutes with 50-60% maximum heart rate strength exercises with
upper and lower extremities for 15 minutes with 50-70% 1RM and recovery for 10 minutes) 3 times a
week for 60 minutes, while control group only consumed prescribed drugs. In each group two resting
blood samples were taken before and after training. The data were analyzed with t-student method with
significant level at (P<0.05). The result of this study showed that serum leptin levels in experimental
group were significantly decreased (P<0.0001), But increased in control group did not significantly
increased (P<0.75). However, the result suggests that combined training program can decrease serum
leptin levels in men with multiple sclerosis.