نوع مقاله : علمی - پژوهشی

نویسندگان

بخش علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شیراز، شیراز، ایران

چکیده

هدف: فعالیت ورزشی هوازی بسته به شدت و مدت فعالیت منجر به تغییراتی در عوامل همودینامیکی و دستگاه هموستاتیک در بیماران پرفشار خونی می­شود که در صورت اعمال محدودیت جریان خون در زمان فعالیت می­توان انتظار تغییرات متفاوتی داشت. بنابراین، هدف از پژوهش حاضر، بررسی پاسخ برخی شاخص‌های همودینامیک و انعقادی به یک جلسه فعالیت ورزشی هوازی با و بدون محدودیت جریان خون در بیماران پرفشار خونی بود.
روش‌ها: تعداد 10 بیمار پرفشار خونی در 2 جلسه فعالیت هوازی (5 نوبت، هر نوبت 2 دقیقه‌ فعالیت با سرعت 4 کیلومتر در ساعت با یک دقیقه استراحت‌ غیرفعال) با و بدون محدودیت جریان خون با طرح توازن متقابل شرکت کردند. فشارخون قبل، بلافاصله، 5، 10، 15، 30 و 60 دقیقه پس از فعالیت، تعداد پلاکت­ها، زمان پروترومبین و زمان نسبی ترومبوپلاستین فعال شده قبل، بلافاصله، 30 دقیقه و 24 ساعت پس از فعالیت، ضربان قلب و شاخص درک از فشار نیز در نوبت‌های مختلف فعالیت اندازه‌گیری شد.
نتایج: اثر زمان در همه عوامل اندازه‌گیری شده غیر از تعداد پلاکت­ها (055/0=P) معنا­دار بود (001/0>P) در حالی که تعامل زمان- شرایط فعالیت غیر از ضربان قلب (011/0=P) در بقیه عوامل غیرمعنا­دار بود ­(05/0<P).
نتیجه‌گیری: براساس نتایج، محدودیت جریان خون منجر به افزایش عوامل همودینامیکی و کاهش زمان تشکیل لخته در بیماران پرفشارخونی شد ولی تفاوت‌های موجود بین فعالیت هوازی با و بدون جریان خون معنا‌دار نبود، بنابراین، به نظر می‌رسد فعالیت با محدودیت جریان خون خطر اضافی را بر دستگاه قلبی- عروقی و عوامل انعقادی افراد میانسال دارای پرفشار خونی اعمال نمی‌کند.

کلیدواژه‌ها

عنوان مقاله [English]

Acute Effect of Single Bout Aerobic exercise with and without Blood Flow Restriction on Hemodynamic and Coagulation Indicators in Hypertension Disease

نویسندگان [English]

  • Zahra Karimi Ahmadabadi
  • Javad Nemati
  • Seyed Hesamuddin Mousavinia
  • Rasoul Rezaei

Department of Sports Science, Faculty of Educational Sciences and Psychology, Shiraz University, Shiraz, Iran

چکیده [English]

Purpose: Depending on the intensity and duration of activity, aerobic exercise leads to changes in hemodynamic factors and the hemostatic system in hypertensive patients, which can be expected to change if blood flow is restricted during exercise. Therefore, the purpose of the present study was to investigate the response of some hemodynamic and coagulation indicators to aerobic exercise with and without blood flow restriction in hypertensive patients.
Methods: 10 hypertensive patients participated in two sessions of aerobic exercise (five bouts, two minutes of exercise at a speed of four km / h /one minute of inactive recovery) with and without blood flow restriction in a cross-over design. Blood pressure was measured before, immediately, five, 10, 15, 30 and 60 minutes after exercise. Platelet counts, Prothrombin Time and activated Partial Thromboplastin Time were taken before, immediately, 30 minutes and 24 hours after exercise. Heart rate and rate of perceived exertion were also measured at different times of exercise.
Results: The effect of time was significant on all measured factors (P < 0.001) except platelet counts (P = 0.055), while the time-condition interaction was non-significant on other factors (P > 0.05) except heart rate (P = 0.011).
Conclusion: Based on the results, blood flow restriction increased hemodynamic factors and decreased clotting time in hypertensive patients, but the differences between aerobic exercise with and without blood flow restriction were not significant, so it seems that exercise with limited blood flow does not pose an additional risk on the cardiovascular system and coagulation factors of middle-aged people with hypertension.

کلیدواژه‌ها [English]

  • Blood pressure
  • heart rate
  • Platelet counts
  • Prothrombin Time
  • activated Partial Thromboplastin Time
  1. Chockalingam A. Impact of world hypertension day. Canadian Journal of Cardiology. 2007;23(7):517-9.
  2. Lip G. Hypertension and the prothrombotic state. Journal of human hypertension. 2000;14(10):687-90.
  3. Blumenthal JA, Babyak MA, Hinderliter A, Watkins LL, Craighead L, Lin P-H, et al. Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Archives of internal medicine. 2010;170(2):126-35.
  4. Lippi G, Maffulli N. Biological influence of physical exercise on hemostasis. Semin Thromb Hemost. 2009;35(3):269-76.
  5. Cadroy Y, Pillard F, Sakariassen KS, Thalamas C, Boneu B, Riviere D. Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers. Journal of applied physiology. 2002;93(3):829-33.
  6. Ersöz G, Zergeroǧlu A, Fıçıcılar H, Özcan H, Öztekin P, Aytaç S, et al. Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. Thrombosis research. 2002;108(5-6):297-301.
  7. Smith DL, Fernhall B. Advanced cardiovascular exercise physiology: Human Kinetics; 2011.
  8. Tahmasebi W, Ahmadizad S, Howanloo F, Jamshidi AA. Acute responses of platelet indices to concentric isotonic and isokinetic contractions in healthy men Sport and Exercise Physiology. 2012;5(2):811-20.
  9. Lippi G, Salvagno GL, Tarperi C, Gelati M, Montagnana M, Danese E, et al., editors. Prothrombotic state induced by middle-distance endurance exercise in middle-aged athletes. Seminars in thrombosis and hemostasis; 2018: Thieme Medical Publishers.
  10. Tarperi C, Salvagno GL, Schena F, Lippi G. Strenuous physical exercise and hematological indices of cardiovascular risk: the exception case of a 93-year-old man running a 100-km distance. Ann Blood. 2017;2(8).
  11. Lekakis J, Triantafyllidi H, Galea V, Koutroumbi M, Theodoridis T, Komporozos C, et al. The immediate effect of aerobic exercise on haemostatic parameters in patients with recently diagnosed mild to moderate essential hypertension. Journal of thrombosis and thrombolysis. 2008;25(2):179-84.
  12. Pope ZK, Willardson JM, Schoenfeld BJ. Exercise and blood flow restriction. The Journal of Strength & Conditioning Research. 2013;27(10):2914-26.
  13. Suga T, Okita K, Morita N, Yokota T, Hirabayashi K, Horiuchi M, et al. Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. Journal of Applied Physiology. 2009;106(4):1119-24.
  14. Anderson G, Rhodes E. A review of blood lactate and ventilatory methods of detecting transition thresholds. Sports Medicine. 1989;8(1):43-55.
  15. Klabunde R. Cardiovascular physiology concepts: Lippincott Williams & Wilkins; 2011.
  16. Neto GR, Sousa MS, Costa PB, Salles BF, Novaes GS, Novaes JS. Hypotensive effects of resistance exercises with blood flow restriction. The Journal of Strength & Conditioning Research. 2015;29(4):1064-70.
  17. Cezar MA, De Sá CA, Corralo VdS, Copatti SL, Santos GAGd, Grigoletto MEdS. Effects of exercise training with blood flow restriction on blood pressure in medicated hypertensive patients. Motriz: Revista de Educação Física. 2016;22(2):9-17.
  18. Madarame H, Kurano M, Takano H, Iida H, Sato Y, Ohshima H, et al. Effects of low‐intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects. Clinical physiology and functional imaging. 2010;30(3):210-3.
  19. Madarame H, Kurano M, Fukumura K, Fukuda T, Nakajima T. Haemostatic and inflammatory responses to blood flow‐restricted exercise in patients with ischaemic heart disease: a pilot study. Clinical physiology and functional imaging. 2013;33(1):11-7.
  20. Karabulut M, Esparza B, Dowllah IM, Karabulut U. The impact of low-intensity blood flow restriction endurance training on aerobic capacity, hemodynamics, and arterial stiffness. The Journal of Sports Medicine and Physical Fitness. 2020.
  21. Abe T, Kearns CF, Sato Y. Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training. Journal of applied physiology. 2006;100(5):1460-6.
  22. Barili A, da Silva Corralo V, Cardoso AM, Mânica A, Bonadiman BdSR, Bagatini MD, et al. Acute responses of hemodynamic and oxidative stress parameters to aerobic exercise with blood flow restriction in hypertensive elderly women. Molecular biology reports. 2018;45(5):1099-109.
  23. Silva JCG, Neto EP, Brittar ST, Domingos-Gomes JR, Neto GR, Cirilo-Sousa MS. Effect of interval and continuous aerobic exercise with and without restriction of blood flow on post-exercise blood pressure/Efeito do exercicio aerobio intervalado e continuo com e sem restricao de fluxo sanguineo sobre a pressao arterial pos-exercicio. Motricidade. 2018;14(S1):89-97.
  24. SILVA JC, NETO EP, Neto GR, Bemben MG, Patterson SD, Batista G, et al. Acute and chronic adaptations of aerobic exercise with blood flow restriction: a systematic review. Frontiers in Physiology. 2019;10:1239.
  25. Loenneke JP, Thrower AD, Balapur A, Barnes JT, Pujol TJ. The energy requirement of walking with restricted blood flow. Sport Science. 2011;4(2):7-11.
  26. de Souza Pfeiffer P, Cirilo-Sousa MS, Dos Santos HH. Effects of different percentages of blood flow restriction on energy expenditure. International journal of sports medicine. 2019;40(03):186-90.
  27. Renzi CP, Tanaka H, Sugawara J. Effects of leg blood flow restriction during walking on cardiovascular function. Medicine and science in sports and exercise. 2010;42(4):726.
  28. Silva JC, Domingos-Gomes JR, Freitas ED, Neto GR, Aniceto RR, Bemben MG, et al. Physiological and perceptual responses to aerobic exercise with and without blood flow restriction. J Strength Cond Res doi. 2019;10.
  29. Naserkhani F, Mehdizadeh R. The acute response of hemodynamic parameters to walking on a treadmill with blood flow restriction in sedentary young girls. Sport Physiology & Management Investigations. 2018;9(4):43-53.
  30. Karabulut M, Garcia SD. Hemodynamic responses and energy expenditure during blood flow restriction exercise in obese population. Clinical physiology and functional imaging. 2017;37(1):1-7.
  31. Ozaki H, Brechue WF, Sakamaki M, Yasuda T, Nishikawa M, Aoki N, et al. Metabolic and cardiovascular responses to upright cycle exercise with leg blood flow reduction. Journal of sports science & medicine. 2010;9(2):224.
  32. Ilbeigi S, Yousefi M, Ghasemi F. Effect of one session of high intensity interval exercise with and without blood flow restriction on electrical selected muscles activity of brachial in trained female

Paramedical Sciences & Rehabilitation. 2021;9(4):7-15.

  1. Schamne JC, Ferreira Junior A, Araújo ACd, Lima-Silva AE, Bertuzzi RCdM, Okuno NM. Cardiac autonomic responses during and after a single session of aerobic exercise with and without blood flow restriction. Motriz: Revista de Educação Física. 2019;25(3).
  2. Rock G, Tittley P, Pipe A. Coagulation factor changes following endurance exercise. Clinical journal of sport medicine: official journal of the Canadian Academy of Sport Medicine. 1997;7(2):94-9.
  3. Ikarugi H, Taka T, Nakajima S, Kato N, Ueda T, Matsumura K, et al. Detection of a prothrombotic state after acute aerobic exercise. Thrombosis research. 1997;85(4):351-6.
  4. El-Sayed MS, Ali ZE-S, Ahmadizad S. Exercise and training effects on blood haemostasis in health and disease. Sports medicine. 2004;34(3):181-200.
  5. Ribeiro J, Almeida-Dias A, Ascensão A, Magalhães J, Oliveira A, Carlson J, et al. Hemostatic response to acute physical exercise in healthy adolescents. Journal of science and medicine in sport. 2007;10(3):164-9.
  6. BASHAFAAT H, AFZALPOUR MI, FALLAHI AA, NAZIFI S, ILBEIGI S. The effects of acute interval cycling and blood flow restriction on hematologic factors of beginner cyclists. Turkish Journal of Sport and Exercise. 2017;19(1):70-6.
  7. Nakajima T, Takano H, Kurano M, Iida H, Kubota N, Yasuda T, et al. Effects of KAATSU training on haemostasis in healthy subjects. International Journal of KAATSU Training Research. 2007;3(1):11-20.
  8. Hegde SS, Goldfarb AH, Hegde S. Clotting and fibrinolytic activity change during the 1 h after a submaximal run. Medicine and science in sports and exercise. 2001;33(6):887-92.
  9. Ahmadizad S, Nouri-Habashi A, Rahmani H, Maleki M, Naderi N, Lotfian S, et al. Platelet activation and function in response to high intensity interval exercise and moderate continuous exercise in CABG and PCI patients. Clinical hemorheology and microcirculation. 2016;64(4):911-9.
  10. Preston RA, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Valle M, et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension. 2003;41(2):211-7.
  11. Naesh O, Haedersdal C, Hindberg I, Trap‐Jensen J. Platelet activation in mental stress. Clinical Physiology. 1993;13(3):299-307.