نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه علوم ورزشی، دانشکده ادبیات، دانشگاه زابل، زابل ایران
2 گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه سیستان و بلوچستان، زاهدان، ایران.
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background& purpose: Nowadays, exercises activity and the use of food supplements containing flavonoids are considered as the main drivers of positive regulation of nerve growth factors and improvement of neuromuscular function. Quercetin is one of the plant flavonoids that crosses the blood-brain barrier and plays an effective role in improving brain health. The aim of this research was to investigate the effect of quercetin supplementation on the response of sirtuin-1 (SIRT-1), brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) to high intensity interval and continuous exercises in female athletes
Materials and Methods:
This is a semi-experimental, double-blind, practical study with a pre-test-post-test design. 40 female athletes from Zabol University with sports experience between one and three years (average age: 21.3±61.03; body mass index: 21.79±3.12) were selected by purposive sampling method and were randomly divided into equal groups including: 1) high intensity interval exercise+ quercetin, 2) continuous exercise + quercetin, 3) high intensity interval + placebo and 4) continuous + placebo. At the beginning and at the end of 14 days, the participants performed a session of continuous exercise (with an intensity of 60% of maximum oxygen consumption (VO2max)) and interval exercise (performing 4 intervals of 4 minutes with an intensity of 90% of VO2max) and during these 14 days,
the supplement and placebo groups consumed two 500 mg capsules of quercetin and dextrose daily.
Fasting blood sampling in the first four stages (before and immediately after the first acute activity) and at the end of 14 days of quercetin supplementation (before and immediately after the second acute activity) to measure SIRT-1, BDNF and IGF-1 by ELISA method was performed. Statistical analysis was performed using the analysis of variance with repeated measures and Bonferroni post hoc.
Results: After high intensity interval and continuous exercises, the response of SIRT-1 (P≤0.001), BDNF (P≤0.001) and IGF-1 (P≤0.001) increased significantly. After 14 days of quercetin consumption, the response of SIRT-1 (P=0.01 and P=0.001), BDNF (P=0.01 and P=0.01) and IGF-1 (P=0.001 and P=0.001) to acute high intensity interval and continuous exercises increased significantly. However, no significant difference was observed between the response of SIRT-1 (P=0.14), BDNF (P=0.32) and IGF-1 (P=0.16) to high intensity interval and continuous exercises.
Conclusions: It seems that short-term quercetin supplementation increases the baseline levels and response of SIRT-1, BDNF and IGF-1 indices to high intensity interval and continuous exercises in female athletes, and probably in this way, it will stimulate nerve growth and improve neuromuscular function, but two types of high-intensity interval and continuous exercises did not make a difference in the response of these indicators, which requires further study in this field.
کلیدواژهها [English]
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