تأثیر رژیم غذایی به‌همراه لیراگلوتاید و تمرین ورزشی بر ترکیب بدن و حفظ وزن در زنان چاق

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه علوم ورزشی، دانشکدۀ علوم انسانی، دانشگاه سمنان، سمنان، ایران

چکیده

زمینه و هدف: چاقی یک اختلال پیچیده و چندعاملی است که با افزایش بافت چربی به‌وجود می‌آید. اختلال‌های سوخت‌وسازی همچون دیابت نوع دو، فشار خون سراسری و عمومی، دیس لیپیدمی، و بیماری عروق کرونر از عوارض چاقی است. کاهش وزن می‌تواند عوارض ناشی از چاقی را محدود کند. با این همه، حفظ وزن جدید پس از پایان دورۀ کاهش وزن دشوار است. هدف این پژوهش مقایسۀ اثر رژیم غذایی به‌همراه تزریق داروی لیراگلوتاید و تمرین ورزشی، بر کاهش وزن، ترکیب بدنی و حفظ وزن جدید زنان چاق بود.
مواد و روش‌ها: آزمودنی‌های پژوهش از بین زنان چاق شهر مشهد، 234 نفر با 30P با نرم‌افزار آماری SPSS26 انجام شد.
نتایج: ارزیابی درون‌گروهی نشان داد که بین پیش‌آزمون و پس‌آزمون گروه‌ها پس از مداخله در همۀ متغیرهای پژوهش تفاوت معناداری وجود دارد. ارزیابی بین‌گروهی کاهش وزن بیشتر را در گروه‌های لیراگلوتاید (7/6- کیلوگرم) لیراگلوتاید و تمرین ورزشی (7/8- کیلوگرم) و تمرین ورزشی (5/6- کیلوگرم) نسبت به رژیم تنها (8/3-کیلوگرم) نشان داد. اندازه‌گیری وزن پس از یک سال نشان داد که روند کاهش وزن در گروه‌های تمرین ورزشی (13/4- کیلوگرم) لیراگلوتاید و تمرین ورزشی (22/2- کیلوگرم) و رژیم (73/2- کیلوگرم) ادامه یافت و در گروه لیراگلوتاید وزن به‌دست‌آمده حفظ شد. دور کمر در گروه‌های تمرین ورزشی و لیراگلوتاید و گروه تمرین ورزشی به‌ترتیب 8 و 7 سانتی‌متر و در گروه‌های رژیم و لیراگلوتاید 5 سانتی‌متر کاهش داشت.
نتیجه‌گیری: تمرین ورزشی، رژیم و تزریق لیراگلوتاید به کاهش وزن و شاخص تودۀ بدنی منجر شد. تغییر سبک زندگی با و بدون تزریق دارو به حفظ کاهش وزن جدید یک سال پس از مداخله منتج شد.
 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effects of diet plus liraglutide and exercise training on body composition and weight maintenance in obese women

نویسندگان [English]

  • Arezoo Rezaee
  • Hakimeh Akbari
Department of Sport Sciences, Faculty of Humanities, Semnan University, Semnan, Iran
چکیده [English]

Background and Purpose: Obesity is a complex metabolic disorder characterized by an imbalance in energy hemostasis and abnormal increases of adipose tissue. Obesity is directly related to cardiovascular risk factors, including dyslipidemia, type 2 diabetes, and hypertension. Body weight loss can significantly reduce the risk of developing obesity-related complications. However, long-term maintanance of weight loss is difficult. This study aimed at comparing the effect of diet along with liraglutide drug injection and exercise training on weight loss, body composition, weight loss and maintenance in obese women.
Material and Methods: For this purepose, 234 women with BMI>30 kg/m2 and average age of 34±9 years old were divided into four groups: diet (n=75), exercise+diet (n=48), liraglutide+diet (n=56), and liraglutide+exercise+diet (n=55). Body composition and anthropometric variables were measured before and after 12 weeks intervention. All groups had a low-calorie diet (caloric deficit of 500-600 kcal daily). Two groups of exercise training with and without liraglutide performed combined exercises (180-220 minutes of aerobic training plus two days of resistance training per week). In two liraglutide groups, the medicine was administered by subcutaneous injection. The initial dose was 0.6 mg daily and increased to 1.2 mg in the second week, and 1.8 mg in the third week until the twelfth week. Body composition variables were measured before, and after 12 weeks period. The subjects' weight was measured one year after the start of the intervention. Data were analyzed using variance analysis with repeated measurements at a significant level (P < 0.05) with SPSS26 statistical software.
Results: Within-group comparisons showed that there is a significant difference between the pre- and post-test measurements for all variables (p<0.01). Moreover,  between-group comparisons revealed significant differences among the study groups for weight, BMI, waist circumference and WHtR (p<0.05). The follow-up test showed more weight loss in the groups of liraglutide (-6.7 kg), liraglutide and exercise training (-8.7 kg) and exercise training (-6.5 kg) compared to diet (-3.8 kg). Weight measurement after one year showed that the trend of weight loss continued in the exercise training (-4.13 kg), liraglutide +exercise training (-2.22 kg) and diet (-2.73 kg) groups, whereas, in the liraglutide group there was a weight maintenance with no significant changes. Waist circumference decreased by 8 and 7 cm in the exercise training+liraglutide, and exercise training groups, respectively, and by 5 cm in the diet+liraglutide groups.
Conclusion: Physical activity, diet and liraglutide injection led to weight loss and reductions in body mass index. The combination of modified lifestyle and drug injection enhanced long-term maintanance ofweight loss.
 

کلیدواژه‌ها [English]

  • Lifestyle
  • drug intervention
  • low-calorie diet
  • waist circumference
  • weight maintenance

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  • تاریخ دریافت: 13 تیر 1403
  • تاریخ بازنگری: 28 شهریور 1403
  • تاریخ پذیرش: 02 مهر 1403
  • تاریخ اولین انتشار: 02 مهر 1403
  • تاریخ انتشار: 01 آبان 1403

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