Journal of Sport and Exercise Physiology

Journal of Sport and Exercise Physiology

The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats

Document Type : original article

Authors
babisan askari 1
nahid bijeh 2
amir rashidlamir 2
1 PhD student in Sport Physiology, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2 Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
10.52547/joeppa.12.1.115
Abstract
Abstract
Purpose: The aim of this study was to determine the effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats. Methods: A total of 28 male Wistar rats were randomly divided into 4 groups; saline injected control (Control), resistance training+saline injected (Training), resistance training+IGF-1 injected (Combined) and IGF-1 injected (Injection). Resistance training protocol consisted of climbing (three days/week, 5 reps/3 sets) a ladder carrying a load suspended from the tail for 8 weeks. IGF-1 and saline (1.5 µg/kg/day) were injected before and after exercise sessions. Three days after the last bout of exercise, colorectal tissues were collected and gene expression levels were analyzed using real-time PCR. Results: In Training, Combined and Injection groups, p53 expression in the colorectal decreased compared with Control (p
Keywords
Key Words: Exercise training
colorectal cancer
insulin
like growth factor
1
Apoptosis
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  • Receive Date 16 January 2018
  • Revise Date 07 February 2021
  • Accept Date 31 December 2020
  • First Publish Date 31 December 2020
  • Publish Date 20 February 2019