اثر هشت هفته تمرین مقاومتی و استقامتی بر برخی عوامل آنژیوژنزی بافت هیپوکمپ، در موش‌های صحرایی نر نژاد ویستار

نوع مقاله : علمی - پژوهشی

نویسندگان

دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تربیت دبیر شهید رجایی، تهران، ایران

چکیده

هدف: یکی از سازگاری‌های حاصله ناشی از تمرینات ورزشی، افزایش چگالی مویرگی یا آنژیوژنز است. افزایش خون‌رسانی به بافت هیپوکمپ سبب بهبود حافظه، یادگیری و فرایند نوروژنز می‌شود و از بروز بیماری‌های مغزی مانند آلزایمر جلوگیری می‌کند. هدف از این پژوهش مقایسة تأثیر 8 هفته تمرین مقاومتی و دویدن استقامتی بر سطوح VEGF-A و FGF-2 بافت هیپوکمپ در موش‌های صحرایی نر نژاد ویستار بود.
روش‌ها: به این منظور تعداد 32 سر موش صحرایی نر نژاد ویستار در قالب یک طرح تجربه- توسعه‌ای به‌طور تصادفی در 4 گروه (تمرین مقاومتی، دویدن، شم تمرین و کنترل) جایگزین شدند و گروه‌های تمرینی به مدت 8 هفته به تمرین ورزشی پرداختند. برای اندازه‌گیری غلظت‌های VEGF-A و FGF-2 بافت هیپوکمپ از روش الایزای ساندویچی و برای آزمون فرضیه‌ها از آزمون تحلیل واریانس یکراهه و آزمون تعقیبی توکی استفاده شد.
نتایج: نتایج نشان داد که 8 هفته تمرین مقاومتی و استقامتی به‌ترتیب سبب افزایش معنادار VEGF-A (000/0P=)،
 (000/0P=) و FGF-2 (000/0P=)، (000/0P=)  نسبت به گروه کنترل می‌شود. همچنین تفاوت معناداری در غلظت VEGF-A (000/0P=)  و FGF-2 (000/0P=)  هیپوکمپ، بین گروه‌های تمرین مقاومتی و تمرین دویدن استقامتی وجود دارد. علاوه‌بر این بین گروه شم تمرین و کنترل در شاخص‌های VEGF-A (982/0P=) و FGF-2 (000/1P=) هیپوکمپ تفاوت معناداری مشاهده نشد.
نتیجه‌گیری: نتایج نشان می‌دهد که 8 هفته تمرین مقاومتی، بیشتر از تمرین دویدن استقامتی سبب افزایش معنادار عوامل مؤثر در رگ‌زایی در بافت هیپوکمپ موش‌های صحرایی نر نژاد ویستار می‌شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Eight Weeks Resistance and Endurance training on Some Angiogenesis factors of Hippocampus Tissue in male Wistar rats

نویسندگان [English]

  • Mojtaba Sadegh Ghomi
  • Majid Kashef
  • Mojtaba Salehpour
Faculty of Physical Education and Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
چکیده [English]

Purpose: One of the cause of adaptations due to exercise training is increased capillary density or angiogenesis. increased blood flow to hippocampus tissue causes improvement of memory, learning and neurogenesis process and prevention from accession brain disease like Alzheimer. The Aim of this study was to compare the effect of Eight weeks resistance and Endurance running on VEGF-A and FGF-2 levels of hippocampus tissue in male Wistar rats.
Methods: This study in aim perspective was developmental and in method perspective was Experimental. For this aim 32 male Wistar rats, divided randomly in four groups (Resistance Training, Running, Sham and control) and training groups exercised for eight weeks. For evaluation of VEGF-A and FGF-2 concentrations of hippocampus tissue used from sandwich Elisa method and for hypothesizes test from one-way ANOVA and Tukey post hoc used.
Results: Results show that Eight weeks’ resistance and endurance training Respectively cause significant increase in VEGF-A (P = 0.000), (P = 0.000) and FGF-2 (P = 0.000), (P = 0.000) than to control group. Also there are significant different in concentrations of VEGF-A (P = 0.000) and FGF-2 (P = 0.000) of hippocampus tissue between resistance and endurance running groups. In addition, no significant differences was observed in VEGF-A (P = 0.982) and FGF-2 (P = 1.000) indexes between exercise sham and control groups.
Conclusion: Results of this study show that eight weeks’ resistance training cause more significant increase on effective angiogenic factors in hippocampus tissue of male Wistar rats than endurance running training group.

کلیدواژه‌ها [English]

  • Resistance exercise
  • Endurance exercise
  • Hippocampus
  • VEGF-A
  • FGF-2
  • Angiogenesis
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  • تاریخ دریافت: 31 فروردین 1399
  • تاریخ بازنگری: 21 فروردین 1400
  • تاریخ پذیرش: 01 اردیبهشت 1400
  • تاریخ اولین انتشار: 01 مهر 1400
  • تاریخ انتشار: 01 مهر 1400