The effect of different intensity circuit resistance training on gremlin-1, Macrophage migration inhibitory factor and some cardiovascular risk factors in obese men

Document Type : original article


1 Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran

2 2Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran


Background and Purpose: More Adipose tissue is associated with the increase of inflammatory markers in obesity. This study aimed to evaluate the effect of different intensity circuit resistance training on gremlin-1, Macrophage migration inhibitory factor and some cardiovascular risk factors in obese men.
Materials and Methods: In a semi-experimental trial, 44 obese men were selected and randomly divided into four groups including control (n=11), low intensity circuit resistance training (n=11), moderate intensity circuit resistance training (n=11) and high-intensity circuit resistance training (n=11) groups. Resistance training was performed in different intensities included 1) High-intensity circuit resistance training (80% 1RM) 2) Moderate intensity circuit resistance (60% 1RM) and 3) Low intensity circuit resistance training (40% 1RM), three sessions per week for 12 weeks. Serum levels of gremlin-1, MIFand Lipid profile (cholesterol, triglyceride, LDL and HDL) were measured using kit and ELISA method. Data were analyzed with Analysis of variance with repeated measures, dependent t-test and Bonferroni post hoc test at the P < 0.05.
Results:12 weeks of circular resistance training with low, moderate and high intensity caused a significant decrease in gremlin-1 and MIF levels, significant decrease in cholesterol, triglyceride and LDL-c levels and significant increase in HDL-c levels (P = 0.001).
Conclusion: It seems that circular resistance training with different intensities and especially high intensity can be an effective factor in counteracting the increase in observation of cardiovascular risk factors in obese people.


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  • Receive Date: 14 January 2021
  • Revise Date: 26 September 2021
  • Accept Date: 16 October 2021
  • First Publish Date: 19 June 2022
  • Publish Date: 22 June 2022