Optimization of Muscle Hypertrophy Through a Combined Myorps and Traditional Resistance Protocol: The Mediating Role of Follistatin and Myokines

Bigdeli, Sima; Saidie, Payam; Arazi, Hamid; Rajabi, Hamid

doi:10.48308/joeppa.2026.244037.1449

Optimization of Muscle Hypertrophy Through a Combined Myorps and Traditional Resistance Protocol: The Mediating Role of Follistatin and Myokines

Articles in Press

Document Type : Original Article

Authors

Sima Bigdeli ¹

payam saidie ²

Hamid Arazi ³

Hamid Rajabi ⁴

¹ Faculty of Sport Sciences, University of Guilan, Guilan, Iran

² Exercise Physiology faculty, University of Guilan, Rasht, IRAN

³ Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

⁴ Faculty of Sport Sciences, Kharazmi University of Tehran, Tehran, Iran

10.48308/joeppa.2026.244037.1449

Abstract

Background and Objective: To find the effect of new resistance training, including Myostatin, on hypertrophy compared to other traditional exercises, it is better to examine the balance of the two hormones folstatin and myostatin. Since little research has been done on the Myostatin training system in terms of hormones and there are still uncertainties about it compared to the traditional system, therefore, in this regard, the present study aimed to investigate the effect of resistance training using the Myostatin, traditional and their combination methods on hypertrophy and muscle strength, plasma levels of folstatin and myostatin in trained men.
Materials and Methods: 30 men (age: 20-30 years) who had a history of resistance training for at least one year were selected. Participants were randomly divided into three groups (10 people): Myostatin (MT), traditional (TT) and hybrid training group (HT). Resistance training was performed 3 days a week for 10 weeks. The training intensity in all three groups was 75% of one repetition maximum for weeks 1 to 4, 80% of one repetition maximum for weeks 5 to 7, and 85% of one repetition maximum for weeks 8 to 10. Plasma folstatin and myostatin levels, as well as the cross-sectional area of the rectus femoris, vastus lateralis, and biceps brachii muscles, were measured by ultrasound. Maximum strength of the chest and leg muscles was also evaluated. Data were analyzed with SPSS27 software at a significance level of P

Keywords

Myorps

Traditional

Follistatin

Myostatin

Hypertrophy

Subjects