Introduction: The aim of this study was to investigate the effect of 12 weeks walking on inflammatory factors
in postmenopausal women with breast cancer. Methods: nineteen postmenopausal women with breast cancer
with range age of 50 to 65 years (55.05±2.7) who received surgery, chemotherapy and radiation-therapy with
current hormone therapy by letrozol were randomly divided into two groups; (Control:8, experimental:11).
Subjects in the experimental group were performed 12 weeks exercise training program which consisted of 25
to 45 minutes of walking with intensity of %45 -%65 of THR, three times a week. The control group did not
participate in exercise training. In pre and post tests, CRP, IL-6, TNF-α, anthropometric variables (body
weight, BMI, WHR), body fat percentage and Vo2peak were measured in both groups. Data were analyzed
through analysis of covariance (ANCOVA) and t test (P<0.05). Results: The results of this study showed that
Vo2peak, body weight and BMI had significant differences between the experimental and control groups, after
12 weeks (P<0.05). There is no significant differences between CRP, IL-6, TNF-α, WHR and body fat
percentage, in both groups (P>0.05). After 12 weeks, body weight was decreased in the experimental group
and was increased in control group; BMI was decreased in the experimental group and was increased in control
group. Also, VO2peak was increased in the experimental group and was decreased in control group. Conclusion:
It can be concluded that 12 weeks walking there have no effect on inflammatory factors in postmenopausal
women with breast cancer, but may improve VO2peak, body weight and BMI.