determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men

Document Type : original article


1 Department of Physical Education and Sports Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran

2 Department of Physical Education and Sports Sciences, Yadegare Emam Branch,Shahre Ray, Islamic Azad University of Tehran, Iran

3 PHD student of biochemistry and sports metabolism, Department of Physical Education and Sports Sciences, Tehran Markaz Branch, Islamic Azad University, Tehran, Iran


Objective: The aim of this study was to determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men. Methods: 20 obese men (age 29/76±2/01 years, height 1/79±0/07m, weight 108/24±5/69 kg, BMI 33/49±1/18kg/square meters) divided into resistance training and control groups. The resistance training consisted of 6 stations with 55-75% of one repetition maximum, 3 days a week for 8 weeks. Blood in two phases, before and after 8 weeks (48 hours after the last training session) was collected after 12 hours fasting. Data were analyzed with ANONA repeated measures at P≤0.05. Results: serum levels of GLP-1 training group compared with the group control significantly increased (P=0.027). Glucose and DPP-4 serum levels of training group were significantly decreased compared with the control group (P = 0.019 and P = 0.003). But in training group did not change insulin resistance compared with the control group (P = 0.49). Conclusion: probably Protocol of resistance training due to in a significant increase in GLP-1 and significantly reduced in DPP-4 and these changes is Accompanied with reducing appetite and the regulation of glucose metabolism in obese men, but probably either had no significant effect on insulin resistance or more time of resistance training requires to see a significant difference in the parameter.


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Volume 10, Issue 1 - Serial Number 1
September 2017
Pages 21-30
  • Receive Date: 28 February 2016
  • Revise Date: 07 June 2023
  • Accept Date: 31 December 2020
  • First Publish Date: 31 December 2020
  • Publish Date: 22 November 2017