The effect of eight-week interval hypoxic training on serum level of brain-derived neurotrophic factor in active women

Document Type : original article


Faculty of Physical Education and Sport Science, Kharazmi University, Tehran, Iran


Purpose: In the present study, the effect of eight weeks of interval hypoxic training (respiratory control
method) on the serum level of Brain-derived neurotrophic factor (BDNF) in active women was envestigated.
Methods: Fourteen active women were randomly assigned to either the control (n=7) or experimental (n=7)
group. The women in the control group performed running interval training under normoxi condition and the
subjects in the experimental group performed runnig interval under hypoxic condition for eight weeks. At the
beginning of the survey and 24 hours after the last training session of the eighth week, the blood samples of
both groups were collected to determine serum Brain-derived neurotrophic factor level. KolmogorovSmirnov and Leven's test were used to determine normal distribution of data and homogeneity variation of
groups, respectively. For data analysis, statistical methods including paired and independent-samples t-test
at a significance level (p≤0.05) were used.
Results: The results showed a significant increase in serum levels of Brain-derived neurotrophic factor after
eight-week interval hypoxic training compared to the interval training. In this regard, the study of
betweengroups’differences showed that there is significant difference between post-test phase of control
and experimental groups (P≤0.036). While, the study of withingroups’ differences showed that there was no
significant difference between pre and post-test phase in control group after eight-week interval training
(P=0.157).The difference was significant in experimental group (P≤0.011).
Conclusions: The results of the present study suggest interval hypoxic training has an additive effect in the
levels of Brain-derived neurotrophic factor in active women. Thus, it is a good substitution for training at
altitude and blood flow restriction training in terms of time of performing physical activity, cost and
implementation. Therefore, combining sport training with hypoxic and obtaining the desired results in shorter
time seems to be an appropriate strategy. 


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Volume 11, Issue 1 - Serial Number 1
November 2018
Pages 117-128
  • Receive Date: 16 October 2017
  • Revise Date: 16 February 2018
  • Accept Date: 26 February 2018
  • First Publish Date: 21 January 2019
  • Publish Date: 21 January 2019