نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، واحد بین المللی کیش، دانشگاه آزاد اسلامی، کیش، ایران
2 گروه تربیت بدنی و علوم ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران
3 گروه فیزیولوژی ورزشی، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران
4 گروه تربیت بدنی و علوم ورزشی، واحد شهر قدس، دانشگاه آزاد اسلامی، شهر قدس، ایران
5 گروه تربیت بدنی و علوم ورزشی، واحد بوشهر، دانشگاه آزاد اسلامی، بوشهر، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Purpose: The occurrence of systemic inflammation in prostate tissue is a factor in the progression of prostate cancer (PCa). The aim of the present study was to investigate the effects of simultaneous aerobic training (AT) with gallic acid (GA) on some inflammatory and anti-inflammatory markers of prostate tissue in rats with PCa.
Material and Methods: 40 male rats (age 10- 12 months and weight 260- 300 g) with PCa (with the LNCaP cell line) were randomly assigned to the following groups: 1) PCa, 2) sham (solvent of GA/(Sh)), 3) GA, 4) AT, and 5) AT+GA. Also, to investigate the effect of prostate cancer induction on the research variables, 8 healthy rats were assigned to the healthy control (HC) group. The AT groups ran three sessions per week at an intensity of 15 m/min on a 15 degree incline for 30-60 minutes for eight weeks. The GA groups also consumed daily 20 mg/kg orally.
Results: The levels of VEGF, IL-8 and CSF-1 in the PCa group were significantly higher than HC group (P=0.001). However, in the AT, GA and AT+GA groups, the levels of VEGF, IL-8 and CSF-1 were significantly lower than PCa group. The levels of IL-8, CSF-1 and VEGF in the AT+GA group were significantly lower than AT and GA groups. The levels of VEGF in the GA group were significantly lower than AT group, and the levels of CSF-1 in the AT group were significantly lower than GA group. (P=0.002).
Conclusion: It seems that although AT and GA supplementation only share a common pathway in reducing IL-8, VEGF, and CSF-1, it seems that despite differences in some signaling pathways, these two interventions can simultaneously have a more favorable effect on improving the inflammatory signaling pathway in an animal model of PCa.
Background and Purpose: The occurrence of systemic inflammation in prostate tissue is a factor in the progression of prostate cancer (PCa). The aim of the present study was to investigate the effects of simultaneous aerobic training (AT) with gallic acid (GA) on some inflammatory and anti-inflammatory markers of prostate tissue in rats with PCa.
Material and Methods: 40 male rats (age 10- 12 months and weight 260- 300 g) with PCa (with the LNCaP cell line) were randomly assigned to the following groups: 1) PCa, 2) sham (solvent of GA/(Sh)), 3) GA, 4) AT, and 5) AT+GA. Also, to investigate the effect of prostate cancer induction on the research variables, 8 healthy rats were assigned to the healthy control (HC) group. The AT groups ran three sessions per week at an intensity of 15 m/min on a 15 degree incline for 30-60 minutes for eight weeks. The GA groups also consumed daily 20 mg/kg orally.
Results: The levels of VEGF, IL-8 and CSF-1 in the PCa group were significantly higher than HC group (P=0.001). However, in the AT, GA and AT+GA groups, the levels of VEGF, IL-8 and CSF-1 were significantly lower than PCa group. The levels of IL-8, CSF-1 and VEGF in the AT+GA group were significantly lower than AT and GA groups.The levels of VEGF in the GA group were significantly lower than AT group, and the levels of CSF-1 in the AT group were significantly lower than GA group. (P=0.002).
کلیدواژهها [English]
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