تاثیر 12 هفته تمرینات تداومی با شدت بالا (HICT) به همراه مکمل کورکومین بر مقادیر سرمی مایونکتین، LECT2، FGF21، فتوئین آ

Background and Objective: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in most parts of the world. The pathological spectrum of this disease is associated with different clinical prognoses; and it can generally be divided into two types: nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). In nonalcoholic fatty liver disease, hepatic steatosis manifests itself without inflammation, but in nonalcoholic steatohepatitis, steatosis manifests itself with liver inflammation, which is difficult to differentiate pathologically from alcoholic steatohepatitis. Myonectin, LECT2, FGF21, and fetoin A are known as key biomarkers in the pathogenesis of NAFLD; myonectin and LECT2 increase inflammatory levels, FGF21 modulates insulin resistance, and fetoin A plays a role in regulating lipid metabolism. This study investigated the effects of 12 weeks of high-intensity continuous training (HICT) intervention with curcumin supplementation on serum levels of these biomarkers in men with NAFLD.
Materials and Methods: In this randomized controlled trial, 60 men aged 30-40 years were divided into four groups: training + curcumin (n = 15), continuous training (n = 15), curcumin supplementation (n = 15), and placebo group (n = 15); the high-intensity continuous training group training protocol consisted of 30 minutes of running at an intensity of 75-90% of maximum oxygen consumption. In the first session, training began at an intensity of 75% of maximum oxygen consumption, and gradually, as the subjects' fitness improved, the training intensity was increased by 5% each week; after reaching an intensity of 90%, this condition was maintained until the end of the protocol and the intake of curcumin supplement was one tablet daily for 12 weeks. Serum levels of biomarkers were measured before and after the intervention by ELISA.
Results: The results of the two-by-two analysis of variance test showed that the changes in photoin A, FGF21, LECT2 and myonectin were significant after the exercise intervention, so that the changes in photoin A, FGF21, LECT2 in the curcumin supplement, supplement + exercise and exercise groups had a significant decrease compared to the placebo group, and myonectin also showed a significant increase in the curcumin supplement, supplement + exercise and exercise groups (P<0.05). The results of the paired t-test showed that the within-group changes in photoin A, FGF21, LECT2 and myonectin in the curcumin supplement, supplement + exercise and exercise groups were significant (P<0.05). The findings related to the lipid profile showed that HDL levels increased significantly after the exercise intervention and curcumin supplementation in the curcumin intervention and high-intensity continuous exercise groups compared to the placebo group. Also, the levels of triglycerides, LDL and cholesterol in the curcumin supplement, supplement + exercise and exercise groups were significantly reduced compared to the placebo group (P<0.05). Also, the within-group results in HDL, triglycerides, LDL and cholesterol levels showed a significant difference compared to the pre-test (P<0.05).
Conclusion: These findings indicate the potential of HICT with curcumin as a non-invasive strategy in the management of NAFLD through the regulation of serum biomarkers. Future studies with larger samples and long-term follow-up are recommended.