نوع مقاله : علمی - پژوهشی
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، کردستان، ایران.
2 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، کردستان، ایران
3 گروه علوم ورزشی، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران.
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Purpose:
Obesity is one of the most important metabolic disorders of modern life and is associated with insulin resistance, low-grade chronic inflammation, oxidative stress, and impaired liver function. Among the emerging biomarkers involved in obesity-related metabolic disturbances, the hepatokines Fetuin-A and Fetuin-B have received increasing attention due to their associations with obesity, non-alcoholic fatty liver disease, and metabolic dysfunction. In parallel, exercise training and nutritional interventions are considered effective non-pharmacological strategies for improving these abnormalities. Therefore, the present study aimed to investigate the effects of 12 weeks of combined functional and aerobic training with folic acid supplementation on selected hepatokines in obese men.
Methods:
This study was designed as a randomized, double-blind, placebo-controlled clinical trial with a pretest–posttest format. Forty-four obese men aged 23–32 years were voluntarily recruited according to the inclusion and exclusion criteria and were homogeneously assigned into four groups (n=11 each): control-placebo, supplement, training-placebo, and training-supplement. The intervention lasted 12 weeks and included 40 minutes of functional training consisting of stability, strength, and intermittent exercise blocks, followed by treadmill running at 50–60% of maximum heart rate. Participants in the supplementation groups received 500 µg folic acid daily, whereas placebo groups received visually identical cornstarch tablets. Fasting blood samples were collected 48 hours before and 48 hours after the intervention, and plasma Fetuin-A and Fetuin-B concentrations were measured using ELISA. Data were analyzed using Shapiro–Wilk and Levene’s tests, paired t-test, ANCOVA, Bonferroni post hoc test, and Pearson correlation coefficient in SPSS version 26.
Results:
The findings revealed significant time × group interactions for body weight, body mass index, Fetuin-A, and Fetuin-B (P=0.001). Body weight decreased significantly only in the training-supplement group (P=0.001), whereas body mass index significantly decreased in the training (P=0.012) and training-supplement groups (P=0.001). In addition, Fetuin-A levels significantly decreased in the supplement (P=0.001), training (P=0.001), and training-supplement (P=0.001) groups, while Fetuin-B levels significantly decreased in the supplement (P=0.049), training (P=0.009), and training-supplement (P=0.001) groups, with no significant changes in the control group. The greatest reductions in both hepatokines were observed in the training-supplement group. A significant positive correlation was also found between Fetuin-A and Fetuin-B (r=0.617, P<0.001). Moreover, both hepatokines were positively correlated with body weight.
Conclusion:
Twelve weeks of combined functional and aerobic training, particularly when accompanied by folic acid supplementation, reduced Fetuin-A and Fetuin-B levels in obese men. These effects may be mediated through improved insulin sensitivity, reduced low-grade inflammation, enhanced antioxidant status, and improved hepatic metabolic function. Therefore, combining exercise training with folic acid supplementation may represent an effective strategy for improving obesity-related metabolic disturbances.
کلیدواژهها [English]
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