نوع مقاله : علمی - پژوهشی
نویسندگان
1 دانشیار گروه فیزیولوژی ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
2 گروه فیزیولوژی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
3 کارشناس ارشد گروه فیزیولوژی ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Abstract
Background and Objective: Obesity, as one of the major public health problems, is increasing as a result of decreased physical activity and lifestyle changes and is associated with the incidence of chronic diseases and various cancers. About 25% of cancer cases are related to overweight and inactivity. Among them, breast cancer, as the most common cancer in women, increases under the influence of metabolic, hormonal and inflammatory mechanisms caused by obesity. Evidence suggests a direct relationship between the risk of breast cancer and IGF-1 and IGFALS levels. However, the effect of exercise activities, especially aerobic exercise, on these IGF-1 and IGFALS levels in overweight and obese postmenopausal women has not been fully determined. Therefore, the aim of the present study was to investigate the effect of eight weeks of aerobic exercise on serum IGF-1 levels and IGFALS protein expression in overweight and obese postmenopausal women.
Materials and Methods: This semi-experimental study was conducted on 40 inactive obese postmenopausal women, who were randomly assigned to experimental and control groups. The experimental group participated in an eight-week aerobic exercise program, with four sessions per week, while the control group did not engage in any physical activity or exercise program during the study period. Blood samples were collected from the participants to measure the variables before the intervention and 48 hours after the completion of the exercise program. Serum IGF-1 levels and IGFALS protein expression were measured using standard laboratory methods and specific commercial kits. For statistical analysis, paired t-tests, independent t-tests, and Pearson correlation coefficients were used, and all analyses were performed using SPSS version 23, with a significance level of (P ≥ 0.05).
Findings: The results showed that, compared to the control group, the exercise group exhibited significant increases in serum adiponectin (p = 0.001), HDL (p = 0.001), and maximal oxygen consumption, and significant decreases in LDL (p = 0.006), TG (p = 0.015), TC (p = 0.033), insulin resistance index (p = 0.001), and body composition indices including BMI (p = 0.033), PBF (p = 0.001), and waist circumference (p = 0.001) as a result of the exercise intervention. Furthermore, after eight weeks of aerobic exercise, the exercise group showed significant reductions compared to the control group in serum IGF-1 levels (p = 0.03), IGFALS protein expression (p = 0.04), body weight (p = 0.005), and BMI (p = 0.001). However, changes in WHR (p = 0.1) were not significant between the two groups. Additionally, Pearson correlation analysis indicated a significant correlation between body weight and BMI with IGF-1 and IGFALS following eight weeks of aerobic exercise (P ≥ 0.05).
Conclusion: Based on the findings of this study, implementing aerobic exercises similar to the training program used in this research can be recommended as an effective strategy to modulate molecular factors involved in the development of breast cancer, including IGF-1 and IGFALS, in overweight and obese postmenopausal women.
کلیدواژهها [English]
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