مقایسة اثر هشت هفته تمرین مقاومتی با و بدون محدودیت جریان خون بر عامل القای هایپوکسی و عامل رشد اندوتلیال عروقی در مردان غیرفعال ورزشی دچار پیش‌پرفشاری خون

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه فیزیولوژی ورزش، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران

2 گروه فیزیولوژی ورزش، واحد کنگاور، دانشگاه آزاد اسلامی، کنگاور، ایران

چکیده

زمینه و هدف: پیش‌پرفشاری خون یک نگرانی عمده برای سلامت عمومی است و به‌طور مستقل خطر فشار خون بالا و حوادث قلبی- عروقی بعدی را افزایش می‌دهد و از مهم‌ترین عوامل خطر بروز آترواسکلروزیس، نارسایی قلبی، سکتة مغزی و نارسایی کلیوی در بسیاری از کشورهاست. بنابراین پژوهش حاضر با هدف بررسی تعیین اثر هشت هفته تمرین مقاومتی با محدودیت جریان خون و تمرین مقاومتی سنتی بر سطوح VEGF و HIF-1 در مردان غیرفعال ورزشی دچار پیش‌پرفشاری خون انجام گرفت.
 مواد و روش‌ها: 36 مرد جوان غیرفعال ورزشی مبتلا به پیش‌پرفشاری خون داوطلب شرکت در پژوهش شدند (26/5±5/39 سال؛ 43/2±66/78 کیلوگرم؛ 29/4±91/176 سانتی‌متر) و به‌صورت تصادفی ساده در یکی از سه گروه کنترل (تمرین مقاومتی شدت پایین بدون محدودیت جریان خون)، گروه تمرین مقاومتی شدت پایین با محدودیت جریان خون و گروه تمرین مقاومتی سنتی (تمرین مقاومتی شدت بالا بدون محدودیت جریان خون( قرار گرفتند. برنامه‌های تمرینی به مدت هشت هفته (سه روز در هر هفته) انجام گرفت. تمرین مقاومتی برای گروه کنترل با شدت 30 درصد تکرار بیشینه بدون محدودیت جریان خون و برای گروه تمرینی مقاومتی شدت پایین با محدودیت جریان خون با شدت 30 درصد تکرار بیشینه و برای گروه تمرینی مقاومتی سنتی با شدت 75 درصد تکرار بیشینه انجام گرفت. 48 ساعت پیش و پس از تمرینات، فشار خون سیستولی و دیاستولی با دستگاه فشارسنج و نیز سطوح پلاسما VEGF و HIF-1a به روش الایزا اندازه‌گیری شد. برای ایجاد محدودیت جریان خون از کاف فشاری استفاده شد. به‌منظور تجزیه‌وتحلیل داده‌ها، از نرم‌افزار SPSS نسخة 24 و برای بررسی طبیعی بودن توزیع داده‌ها از آزمون آماری شاپیروویلک و برای همگنی واریانس‌ها از همگنی شیب‌های رگرسیون و آزمون لوین استفاده شد. برای مقایسة میانگین‌های درون‌گروهی و بین‌گروهی به‌ترتیب از آزمون آماری تی وابسته و تحلیل کوواریانس (ANCOVA) با تست تعقیبی بنفرونی استفاده شد.
نتایج: افزایش معناداری در سطح پلاسما VEGF (001/0P=) و HIF-1a (001/0P=) و نیز کاهش معناداری در میزان فشار خون سیستولیک (001/0P=) و دیاستولیک (001/0P=) در دو گروه تجربی در مقایسه با گروه کنترل دیده شد.
نتیجه‌گیری: بر اساس نتایج این پژوهش تمرینات مقاومتی با محدودیت جریان خون اثری مشابه با تمرینات مقاومتی سنتی دارد که می‌توان گفت تمرینات مقاومتی با و بدون محدودیت جریان خون به‌طور ایمن و مؤثر برای بیماران پیش‌پرفشاری خون مفید است.
 
 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Comparison of the effects of 8 weeks of resistance training with and without blood flow restriction on hypoxia-inducible factor 1α and vascular endothelial growth factor in sedentary men with pre-hypertension

نویسندگان [English]

  • Ali Yari 1
  • Sedigheh Hossein pour delavar 1
  • Ali Zabet 2
1 Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
2 Department of Exercise Physiology, Kangavar branch, Islamic Azad University, Kangavar, Iran
چکیده [English]

Background and Purpose: Prehypertension is a major public health concern and independently increases the risk of hypertension and subsequent cardiovascular events. Prehypertension is one of the most significant risk factors for the development of atherosclerosis, heart failure, stroke, and renal failure in many countries. Therefore, in the present study attempts are made to investigate the effects of eight weeks of resistance/blood flow restriction training and traditional resistance training on hypoxia-inducible factor 1α (HIF-1) and vascular endothelial growth factor (VEGF) levels in sedentary men with prehypertension.
Materials and Methods: In the present study, 36 young sedentary men with prehypertension (age, 39.5 ± 5.26 years; weight, 78.66 ± 2.43 kg; height, 176.91 ± 4.29 cm) volunteered to participate in the study. They were randomly assigned to one of three groups: control group (low-intensity resistance training without blood flow restriction), a low-intensity resistance training group with blood flow restriction, and a traditional resistance training group (high-intensity resistance training without blood flow restriction). The training programs were carried out over an eight-week period, three sessions per week. The control group performed resistance exercises at 30% of one-repetition maximum (1RM) without blood flow restriction, while the low-intensity resistance training group with blood flow restriction performed training at 30% of 1RM and traditional resistance training group performed exercises at 75% of 1RM. Forty eight hours before and after the training systolic and diastolic blood pressure were measured using a sphygmomanometer, and plasma levels of VEGF and HIF-1α were measured by using the ELISA method. A pneumatic cuff was employed to induce blood flow restriction. Data were analyzed using SPSS software, version 24. Within- and between-group comparisons were done using dependent t-test and analysis of covariance (ANCOVA) with Bonferroni post-hoc tests for post-hoc comparisons.
Results: A significant increase in VEGF (p = 0.001) and HIF-1α (p = 0.001) plasma levels was observed, along with a significant reduction in systolic blood pressure (p = 0.001) and diastolic blood pressure (p = 0.001) in both experimental groups compared to the control group.
Conclusion: The findings suggest that resistance training with blood flow restriction produces effects comparable to traditional resistance training. Therefore, it can be concluded that resistance training with and without blood flow restriction are safe and effective strategies that can benefit patients with prehypertension.

کلیدواژه‌ها [English]

  • Hypertension
  • Resistance Training
  • Blood Flow Restriction
  • VEGF
  • HIF-1a

مراجع

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  • تاریخ دریافت: 03 مرداد 1403
  • تاریخ بازنگری: 05 شهریور 1403
  • تاریخ پذیرش: 24 شهریور 1403
  • تاریخ اولین انتشار: 24 شهریور 1403
  • تاریخ انتشار: 01 آبان 1403

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