تغییرات آسپروسین، اسپکسین و لپتین متعاقب تمرینات مقاومتی دایره‌ای با شدت‌های بالا و متوسط در مردان مبتلا به دیابت نوع دو

کریمی, محمد

doi:10.48308/joeppa.2024.236760.1292

تغییرات آسپروسین، اسپکسین و لپتین متعاقب تمرینات مقاومتی دایره‌ای با شدت‌های بالا و متوسط در مردان مبتلا به دیابت نوع دو

نوع مقاله : مقاله پژوهشی

نویسنده

محمد کریمی

دانشگاه صنعتی قم، قم، ایران.

10.48308/joeppa.2024.236760.1292

چکیده

زمینه و هدف: بافت چربی به‌عنوان منبعی برای آزادسازی آدیپوکاین‌ها، از جمله آسپروسین، اسپکسین و لپتین، در تنظیم سوخت‌وساز گلوکز و تعامل با انسولین نقش دارد. در دیابت نوع دو، اختلال در مقادیر این هورمون‌ها بر حساسیت انسولینی و سوخت‌وساز گلوکز تأثیر می‌گذارد. تمرینات ورزشی منظم به‌عنوان روشی مؤثر در پیشگیری و درمان غیردارویی دیابت نوع دو مطرح است. هدف این تحقیق بررسی پاسخ آسپروسین، اسپکسین و لپتین به هشت هفته تمرینات مقاومتی دایره‌ای با شدت‌های متوسط و بالا در مردان مبتلا به دیابت نوع دو بود.
مواد و روش‌ها: در این پژوهش نیمه‌تجربی با طرح پیش‌آزمون-پس‌آزمون، 36 مرد مبتلا به دیابت نوع دو (میانگین سنی 6/3 ± 3/40 سال) به‌طور تصادفی به سه گروه کنترل، تمرین مقاومتی دایره‌ای با شدت متوسط (MICT) و تمرین مقاومتی دایره‌ای با شدت بالا (HICT) تقسیم شدند. گروه‌های تمرین یک پروتکل تمرین مقاومتی دایره‌ای را به مدت هشت هفته و سه جلسه در هفته انجام دادند. در گروه MICT، حرکات در سه ست 13 تکراری و با 60 درصد یک تکرار بیشینه و در گروه HICT در سه ست 10 تکراری با 80% یک تکرار بیشینه انجام شد. خون‌گیری پیش و پس از مداخله انجام و مقادیر سرمی آسپروسین، اسپکسین و لپتین به روش الایزا ارزیابی شد. همچنین شاخص HOMA-IR برای ارزیابی حساسیت انسولینی محاسبه شد. برای تحلیل داده‌ها از t همبسته و تحلیل واریانس یکطرفه همراه با آزمون تعقیبی توکی استفاده شد و سطح معناداری 05/0>P در نظر گرفته شد.
نتایج: یافته‌ها نشان داد که هشت هفته تمرینات مقاومتی دایره‌ای با شدت متوسط و بالا به‌طور معناداری وزن بدن (0001/0=P)، آسپروسین (0001/0=P) و لپتین (0001/0=P) را کاهش داد. همچنین سطوح سرمی اسپکسین به‌طور معناداری افزایش یافت (0001/0=P). تمرینات با شدت بالا در همه متغیرهای مورد مطالعه تأثیر بیشتری داشتند و شاخص مقاومت انسولینی نیز کاهش معناداری را نشان داد (0001/0=P).
نتیجه‌گیری: این تحقیق نشان داد که هشت هفته تمرینات مقاومتی دایره‌ای با شدت‌های بالا و متوسط به تغییرات مثبت در سطوح آدیپوکاین‌هایی مانند آسپروسین، اسپکسین و لپتین منجر شد که با بهبود مقاومت انسولینی همراه بود. به‌نظر می‌رسد تمرینات با شدت بالا تأثیر بیشتری در این تغییرات داشته باشند.

کلیدواژه‌ها

موضوعات

فیزیولوژی ورزشی (عمومی)

عنوان مقاله [English]

Changes in Asprosin, spexin, and leptin following circuit resistance training with high and moderate intensities in men with type II diabetes

نویسنده [English]

Mohammad Karimi

Qom University of Technology, Qom, Iran

چکیده [English]

Background and Purpose: Adipose tissue serves as a source for the release of adipokines, including Asprosin, Spexin, and Leptin, which play a role in regulating glucose metabolism and interacting with insulin. In type II diabetes, the disruption of these hormones affect insulin sensitivity and glucose metabolism. Regular exercise is considered an effective method for the non-pharmacological prevention and treatment of type II diabetes. The objective of this study was to investigate the responses of asprosin, spexin, and leptin to eight weeks of circuit resistance training with moderate and high intensities in men with type II diabetes.
Materials and Methods: In this semi-experimental study with a pre-test/post-test design, 36 men with type II diabetes (age, 40.3 ± 3.6 years) were randomly divided into three groups: a control group, a moderate-intensity circuit resistance training group (MICT), and a high-intensity circuit resistance training group (HICT). The training groups followed a circuit resistance training protocol for eight weeks, three sessions per week. In the MICT group, exercises were performed in three sets of 13 repetitions at 60% of one repetition maximum (1RM), while in the HICT group, exercise protocol encompassed three sets of 10 repetitions at 80% of 1RM. Blood samples were taken before and after the intervention to evaluate serum levels of asprosin, spexin, and leptin by using the ELISA technique. Additionally, the HOMA-IR index was calculated to assess insulin resistance. Data analyses were conducted using paired t-tests and one-way ANOVA with Tukey's post hoc test, considering a significance level of p < 0.05.
Results: Data analyses indicated that eight weeks of circuit resistance training at moderate and high intensities significantly reduced body weight (p = 0.0001), asprosin (p = 0.0001), leptin (p = 0.0001) and insulin resistance index (p = 0.0001). Additionally, serum levels of spexin was significantly increased (p = 0.0001). When responses to two exercise protocols were compared, the high-intensity training had a greater impact on all the studied variables.
Conclusion: This study demonstrated that eight weeks of circuit resistance training at high and moderate intensities led to positive changes in the levels of adipokines such as Asprosin, Spexin, and Leptin, which were associated with improved insulin resistance. It appears that high-intensity training had a greater impact than MICT.

کلیدواژه‌ها [English]

Circuit training
Insulin sensitivity
Adipokines
Glucose metabolism

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