تغییرات آسپروسین، اسپکسین و لپتین در پاسخ به تمرینات مقاومتی دایره‌ای با شدت‌های بالا و متوسط در مردان مبتلا به دیابت نوع دو

Background and Purpose: Adipose tissue is a source for releasing adipokines that interact with insulin to regulate glucose metabolism. Some of these adipokines that can be mentioned include asprosin, spexin and leptin. In the conditions of type 2 diabetes, the amount of these hormones is disturbed and in addition to changes in insulin sensitivity, it leads to disturbances in glucose metabolism. Among the solutions to confrontation with type 2 diabetes, regular exercise as well as the issue of insulin sensitivity can influence energy metabolism in the prevention and non-pharmacological treatment of type 2 diabetes. The purpose of this study was to investigate the response of asprosin, spexin and leptin to the eight weeks of circuit resistance training with moderate and high intensities in men with type 2 diabetes.
Materials and Methods: In this semi-experimental study with a pre-test and post-test design, 36 men with type 2 diabetes with an average age of 40.3 ± 3.6 years were randomly divided into three equal groups (n=12 in each group) including: control, moderate intensity circuit resistance training (MICT) and high intensity circuit resistance training (HICT). The training groups performed a circuit resistance training protocol for eight weeks, with a frequency of three sessions per week and each session consisting of eight movements. In the moderate intensity training group, the movements were performed in three sets of 13 repetitions and with an intensity of 60% of one repetition maximum, and in the high intensity training group, the movements were performed in three sets of 10 repetitions and with an intensity of 80% of one repetition maximum. There was two-minute inactive rest between the sets. 48 hours before and after the training intervention, blood sampling was done under conditions of 10 hours of overnight fasting. The serum levels of asprosin, spexin and leptin were evaluated by ELISA method. To evaluate the insulin sensitivity, HOMA-IR index was measured and calculated. In order to examine the intra-group changes, the paired t-test was used, and the one-way analysis of variance test was used for the between-group changes, accompanied with Tukey's post hoc test. The significance level was set at p<0.05.
Results: The findings indicated that eight weeks of circuit resistance training with moderate and high intensities caused to significant decrease in body weight (p=0.0001), asprosin (p=0.0001) and leptin (p=0.0001). Also, serum levels of spexin were accompanied with significant increase (p=0.0001) in training groups. Between groups comparison, reveals that in all research variables, training with high intensity has more positive effect on these changes. Also, Insulin sensitivity decreased significantly (p=0.0001).
Conclusion: In conclusion, the findings of this study showed that eight weeks of high and moderate intensity circuit resistance training led to positive changes in the levels of adipokines such as, asprosin, spexin and leptin, which are related to glucose metabolism. These changes were associated with improved insulin resistance. By comparing these two training intensities, it seems that the high intensity training has more effects on these changes.