نوع مقاله : مقاله مروری
نویسندگان
1 دانشیار فیزیولوژی ورزشی ، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران.
2 دانشگاه آزاد اسلامی، واحد مریوان، مریوان، ایران،
3 گروه فیزیولوژی ورزشی، دانشکده علوم اجتماعی، دانشگاه کردستان، سنندج، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Purpose: Vaspin (serpin derived from visceral adipose tissue) is an adipokine secreted from adipose tissue that plays a role in regulating glucose and lipid metabolism. Elevated vaspin levels are associated with obesity, metabolic syndrome, and type 2 diabetes (T2DM). The effect of regular exercise training on its levels is not known. Therefore, the present meta-analysis study was conducted with the aim of investigating the effect of various types of regular exercise on vaspin levels in order to obtain more specific results in this field and to improve our knowledge in this field.
Materials and methods: In order to conduct the research, databases including EMBASE, EBSCO, WOS, PubMed, Mogiran, Alam Net and SID site and finally Google Scholar were searched. All the randomized controlled clinical trials from 2000 to 2023 that dealt with aerobic, resistance and HIIT training on the spin index in obese and T2DM subjects were selected. The investigation of fixed and random effects models for the meta-analysis of average effect size in studies related to vaspin was done with the help of CMA2 software. In the initial search, 560 articles related to the topic were found, and finally, based on the criteria, 20 articles were selected as available study samples for analysis. The subgroups related to each class such as age, gender, health status, type of exercise, duration of exercise and BMI were compared and the differences between the subgroups were investigated. Comprehensive software CMA version 2 was used for data analysis. The random effects model was used in case of heterogeneity between studies and the fixed effects model was used in the absence of heterogeneity. The significance level of data analysis was considered using CMA software, P<0.05.
Results: The results of the meta-analysis showed that resistance exercise training (ES=-0.674, 95% CL=-1.021; -0.327, P <0.001) was associated with a significant decrease in vaspin. However, after aerobic and HIIT training, vaspin changes were not significant. In the subgroup analysis, age, gender and type of disease (obese or T2DM) had no significant effect on the effect of exercise on vaspin, but BMI (p=0.005, ES=-0.384) and type of exercise (p=0.001, ES=-0 396/) had a significant effect in terms of the reduction of vaspin, the largest reduction was related to BMI 25 to 30, and the reduction of vaspin due to resistance training was more than other exercises.
Conclusion: The findings of this meta-analysis showed that performing resistance training significantly reduces the amount of vaspin in obese people with T2DM, and people with BMI between 25 and 30 have a greater decrease in vaspin levels by performing resistance training. Age, gender and type of disease (obesity or T2DM) have no significant effect on the effect of training on vaspin. More accurate randomized control studies are needed in relation to the effect of these factors, especially aerobic and HIIT training and different exercise variables in people with other health conditions.
کلیدواژه‌ها [English]
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