تأثیر تمرین ورزشی بر واسپین سرمی در افراد چاق و بیماران دیابت نوع دو: مطالعة متاآنالیز

مقالات آماده انتشار

نوع مقاله : مقاله مروری

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشکدة علوم اجتماعی، دانشگاه کردستان، سنندج، ایران

2 گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد مریوان، مریوان، ایران

چکیده

زمینه و هدف: واسپین (سرپین مشتق از بافت چربی احشایی) یک آدیپوکین ترشح‌شده از بافت چربی است که در تنظیم سوخت‌وساز گلوکز و لیپیدها نقش دارد. افزایش تراز واسپین به چاقی، نشانگان ساخت‌وسازی و دیابت نوع دو (T2DM) وابسته است. اثر انواع تمرین منظم ورزشی بر سطوح آن روشن نیست.
مواد و روش‌ها: همة کارآزمایی‌های بالینی کنترل‌شدة تصادفی از سال 2000 تا 2023 که به انجام تمرین ورزشی هوازی، مقاومتی و HIIT روی نشانگر واسپین در افراد چاق و T2DM پرداخته بودند، از طریق جست‌وجوی نظام‌مند از پایگاه‌های اطلاعاتی شامل WOS، PubMed و Google Scholar انتخاب شدند. در جست‌وجوی اولیه از پایگاه‌های معتبر 560 مقالة مرتبط با موضوع یافت شد که در نهایت بر پایة معیارهای مدنظر، 20 مقاله برای فراتحلیل انتخاب شدند. از الگوی تأثیرات تصادفی در صورت وجود ناهمگونی بین پژوهش‌ها و الگوی تأثیرات ثابت در صورت نبود ناهمگونی برای برآورد اندازة اثر استفاده شد. سطح معناداری 05/0>p در نظر گرفته شد و تجزیه‌وتحلیل داده‌ها توسط نرم‌افزار CMA 3.0، انجام گرفت.
نتایج: نتایج فراتحلیل نشان‌دهندة کاهش معنادار تراز واسپین در اثر تمرین ورزشی با اندازة اثر 260/0-=SMD و فاصلة اطمینان 95 درصد برابر با 517/0- تا 002/0- است (048/0=p). همچنین تمرین مقاومتی (0001/0=p، 327/0-؛ 021/1-=CL 95%، 674/0-=SMD) با کاهش معنادار واسپین همراه بود. با این همه، پس از تمرین هوازی و HIIT تغییرات واسپین معنادار نبود. در بررسی زیرگروه‌ها سن، جنسیت و نوع بیماری (چاق یا T2DM) در اثرگذاری تمرین بر واسپین اثر معناداری نداشت، اما BMI (384/0-=SMD، 005/0=p) و نوع تمرین (396/0-=SMD، 001/0=p) اثر معناداری از لحاظ میزان کاهش واسپین داشتند که بیشترین کاهش مربوط به BMI 25 تا 30 بود و کاهش واسپین ناشی از تمرین مقاومتی بیشتر از تمرین دیگر بود.
نتیجه‌گیری: یافته‌های این فراتحلیل نشان‌دهندة کاهش معنادار تراز واسپین گردش خون در افراد چاق و دارای T2DM بر اثر تمرین ورزشی است؛ همچنین از دیدگاه اثر نوع تمرین، تنها انجام تمرین مقاومتی موجب کاهش معنادار میزان واسپین می‌شود و افراد دارای BMI بین 25 تا 30 با انجام تمرین مقاومتی، کاهش بیشتری در تراز واسپین تجربه کرده‌اند. یافته‌های به‌دست‌آمده از زیرگروه‌های دیگر نشان‌دهندة آن است که اثر تمرین بر تراز واسپین معنادار نیست. پژوهش‌های کنترل تصادفی دقیق‌تری دربارة تأثیر این عوامل به‌ویژه تمرین هوازی و HIIT و متغیرهای مختلف تمرینی در افراد با وضعیت‌های سلامتی دیگر مورد نیاز است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of exercise training on vaspin serum levels in obese individuals and type 2 diabetes patients: a meta-analysis study

نویسندگان [English]

  • Mohammad Rahman Rahimi 1
  • Hassan Faraji 2
  • Fataneh Samzadeh Kermani 1
1 Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran
2 Department of Physical Education and Sport Sciences, Islamic Azad University, Marivan Branch, Marivan, Iran
چکیده [English]

Background and Purpose: Vaspin (serpin derived from visceral adipose tissue) is an adipokine secreted from adipose tissue that plays a role in regulating glucose and lipid metabolism. Elevated vaspin levels are associated with obesity, metabolic syndrome, and type 2 diabetes (T2DM). The effect of regular sports training on its levels is not known.
Materials and Methods: All randomized controlled clinical trials from 2000 to 2023 that performed aerobic, resistance and HIIT exercise training on the vaspin index in obese and T2DM subjects were systemically searched and selected through databases including WOS, PubMed and Google Scholar. In the initial search, 560 articles related to the topic were found and finally, based on the criteria, 20 articles were selected for meta-analysis. The random effects model was used in the case of heterogeneity between studies and the fixed effects model in the absence of heterogeneity was used to calculate the effect size. A significance level of p<0.05 was considered and data analysis was performed by CMA 3.0 software.
Results: The meta-analysis results indicated a significant decrease in vaspin levels due to exercise training with an effect size of SMD=-0.260 and a 95% confidence interval of -0.517 to -0.002 (p=0.048). Also, resistance training (SMD=-0.674, 95% CL=-1.021; -0.327, p=0.001) was associated with a significant decrease in vaspin. However, vaspin changes were not significant after aerobic and HIIT exercise training protocols. In the subgroup analysis, age, gender and type of disease (obese or T2DM) had no significant effect on the effect of training on vaspin, but BMI (p=0.005, SMD =-0.384) and type of exercise (p=0.001, SMD =-0.396) had a significant effect in terms of the reduction of vaspin, the largest reduction was related to BMI 25 to 30, and the reduction of vaspin due to resistance training was more than other exercises.
Conclusion: The general finding of the present meta-analysis indicates a significant decrease in circulating vaspin levels in obese individuals with T2DM as a result of training. Meanwhile, in relation to the type of training, only performing resistance training caused a significant decrease in vaspin levels, and individuals with a BMI between 25 and 30 have experienced a greater decrease in vaspin levels following performing resistance training. The subgroups analysis did not show a significant effect of training on the level of vaspin. More accurate randomized controlled studies are needed to investigate the effect of training type, especially aerobic and HIIT training and different exercise variables in individuals with other health conditions.

کلیدواژه‌ها [English]

  • Physical training
  • Aerobic training
  • Resistance training
  • Serpin derived from visceral fat tissue

مراجع

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    1. Rezaeimanesh D: Responses of plasma levels of irisin, follistatin and insulin resistance index to two types of high intensity interval training in overweight men. Journal of Sport and Exercise Physiology 2024, 16(4):31-40.
    2. Khabiri P: Effect of aerobic exercise on fetoin A: elucidating the relationship between obesity and related metabolic problems. Research in Exercise Nutrition 2023, 2(2):60-47.
    3. Dimova R, Tankova T: The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis. BioMed research international 2015, 2015(1):823481.
    4. Zain S, Pung Y, Mohamed R: Association of vaspin rs2236242 with type 2 diabetes mellitus and obesity: a meta-analysis of case-control studies. Journal of Diabetes & Metabolic Disorders 2023, 22(1):237-243.
    5. Nicholson T, Church C, Tsintzas K, Jones R, Breen L, Davis ET, Baker DJ, Jones SW: Vaspin promotes insulin sensitivity in elderly muscle and is upregulated in obesity. Journal of Endocrinology 2019, 241(1):31-43.
    6. Miyatake N, Wada J, Nakatsuka A, Sakano N, Teshigawara S, Miyachi M, Tabata I, Numata T: Serum vaspin levels are associated with physical activity or physical fitness in Japanese: a pilot study. Environmental health and preventive medicine 2014, 19:200-206.
    7. Heiker JT, Klöting N, Kovacs P, Kuettner EB, Sträter N, Schultz S, Kern M, Stumvoll M, Blüher M, Beck-Sickinger AG: Vaspin inhibits kallikrein 7 by serpin mechanism. Cellular and Molecular Life Sciences 2013, 70:2569-2583.
    8. Feng R, Li Y, Wang C, Luo C, Liu L, Chuo F, Li Q, Sun C: Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: a meta-analysis. Diabetes research and clinical practice 2014, 106(1):88-94.
    9. Wang H, Wang Q: Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis. Brazilian Journal of Medical and Biological Research 2016, 49(7):e5231.
    10. Youn B-S, Kloting N, Kratzsch J, Lee N, Park JW, Song E-S, Ruschke K, Oberbach A, Fasshauer M, Stumvoll M: Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes 2008, 57(2):372-377.
    11. Yang HW, Huang Yg, Gai Cl, Chai Gr, Lee S: Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus. Journal of Diabetes Investigation 2021, 12(4):566-573.
    12. Ji S, Kou W, Luan P, Jian W, Zhuang J, Xu X, Zhao Y, Li H, Peng W: Plasma vaspin is an effective biomarker for evaluation of future cardiovascular events in patients with chest pain: a 5-year retrospective observational study. Annals of Translational Medicine 2020, 8(7).
    13. Askin L, Tanriverdi O, Tibilli H, Turkmen S: Associations between Vaspin levels and coronary artery disease. Cardiovascular Innovations and Applications 2020, 4(3):211.
    14. Seeger J, Ziegelmeier M, Bachmann A, Lossner U, Kratzsch J, Bluher M, Stumvoll M, Fasshauer M: Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. The Journal of Clinical Endocrinology & Metabolism 2008, 93(1):247-251.
    15. Choi SH, Kwak SH, Lee Y, Moon MK, Lim S, Park YJ, Jang HC, Kim MS: Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women. Clinical Endocrinology 2011, 75(5):628-635.
    16. Niyazi A, Yasrebi SMA, Yazdanian M, Mohammad Rahimi GR: High-Intensity Interval Versus Moderate-Intensity Continuous Exercise Training on Glycemic Control, Beta Cell Function, and Aerobic Fitness in Women with Type 2 Diabetes. Biological Research For Nursing 2024, 26(3):449-459.
    17. Lee MK, Jekal Y, Im J-A, Kim E, Lee SH, Park J-H, Chu SH, Chung K-M, Lee HC, Oh EG: Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification. Clinica chimica acta 2010, 411(5-6):381-385.
    18. Kim SM, Cho GJ, Yannakoulia M, Hwang TG, Kim IH, Park EK, Mantzoros CS: Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations. Metabolism 2011, 60(9):1294-1299.
    19. KAZEMI A, RAHMATI M, DABAGHZADEH R, RAISI S, AGHAMOLAIE S: The effect of high volume high intensity interval training on serum visfatin and vaspin, insulin resistance, lipid profile and body composition of overweight men. 2015.
    20. Montazerifar F, Mogharnasi M, Mousavi Gilan R, Dashipour A: The Effect of Endurance Exercise Training on Vaspin, Lipid Profile, and Anthropometric Indices in Young People. Journal of Nutrition and Food Security 2019, 4(4):263-271.
    21. Mogharnasi M, TaheriChadorneshin H, Abbasi-Deloei N: Effect of exercise training type on plasma levels of vaspin, nesfatin-1, and high-sensitivity C-reactive protein in overweight and obese women. Obesity medicine 2019, 13:34-38.
    22. Jalali-Kahnooj B, Batavani MR, Ghofrani M: Effects of 8 weeks of combined training (resistance and endurance) on the serum vaspin level in obese girls. New Approaches in Exercise Physiology 2021, 3(6):99-110.
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  • تاریخ دریافت: 08 مرداد 1403
  • تاریخ بازنگری: 06 آبان 1403
  • تاریخ پذیرش: 02 دی 1403
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