1. Jansen K, Kiefer SM. Understanding brain development: Investing in young adolescents’ cognitive and social-emotional development. Middle School Journal. 2020;51(4):18–25.DOI:https://doi.org/10.1080/00940771.2020.1787749 2. Mualem R, Morales-Quezada L, Farraj RH, Shance S, Bernshtein DH, Cohen S, et al. Econeurobiology and brain development in children: key factors affecting development, behavioral outcomes, and school interventions. Front Public Health. 2024;12:1376075.DOI:https://doi.org/10.3389/fpubh.2024.1376075 3. Srinivas NS, Vimalan V, Padmanabhan P, Gulyas B. An Overview on Cognitive Function Enhancement through Physical Exercises. Brain Sci. 2021;11(10):1289.DOI:https://doi.org/10.3390/brainsci11101289 4. Singh R, Biswas DA. Physiological Role of Orexin/Hypocretin in the Human Body in Motivated Behavior: A Comprehensive Review. Cureus. 2023;15(1):e34009.DOI:https://doi.org/10.7759/cureus.34009 5. Abounoori M, Maddah MM, Ardeshiri MR. Orexin neuropeptides modulate the hippocampal-dependent memory through basolateral amygdala interconnections. Cereb Circ Cogn Behav. 2022;3:100035.DOI:https://doi.org/10.1016/j.cccb.2021.100035 6. Zhuang C, Yan H, Lu J, Zhou Y, Liu Y, Shi G, et al. Compensatory enhancement of orexinergic system functionality induced by amyloid-beta protein: a neuroprotective response in Alzheimer's disease. Front Physiol. 2025;16:1529981.DOI:https://doi.org/10.3389/fphys.2025.1529981 7. Treu SP, Plante DT. Cerebrospinal fluid orexin in Alzheimer's disease: a systematic review and meta-analysis. Sleep Med. 2021;85:230–8.DOI:https://doi.org/10.1016/j.sleep.2021.07.007 8. Polito R, Monda V, Nigro E, Messina A, Di Maio G, Giuliano MT, et al. The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity. Front Physiol. 2020;11:356.DOI:https://doi.org/10.3389/fphys.2020.00356 9. Messina G, Di Bernardo G, Viggiano A, De Luca V, Monda V, Messina A, et al. Exercise increases the level of plasma orexin A in humans. J Basic Clin Physiol Pharmacol. 2016;27(6):611–6.DOI:https://doi.org/10.1515/jbcpp-2015-0133 10. Han D, Shi Y, Han F. The effects of orexin-A and orexin receptors on anxiety- and depression-related behaviors in a male rat model of post-traumatic stress disorder. J Comp Neurol. 2022;530(3):592–606.DOI:https://doi.org/10.1002/cne.25231 11. Han Y, Yuan K, Zheng Y, Lu L. Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders. Neurosci Bull. 2020;36(4):432–48.DOI:https://doi.org/10.1007/s12264-019-00447-9 12. Al-Kuraishy HM, Abdulhadi MH, Hussien NR, Al-Niemi MS, Rasheed HA, Al-Gareeb AI. Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review. Brain Circ. 2020;6(2):70–80.DOI:https://doi.org/10.4103/bc.bc_42_19 13. Bonaventure P, Dugovic C, Shireman B, Preville C, Yun S, Lord B, et al. Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation. Front Pharmacol. 2017;8:357.DOI:https://doi.org/10.3389/fphar.2017.00357 14. Gagliano H, Ortega-Sanchez JA, Nadal R, Armario A. Psychostimulants and forced swim stress interaction: how activation of the hypothalamic-pituitary-adrenal axis and stress-induced hyperglycemia are affected. Psychopharmacology (Berl). 2017;234(19):2859–69.DOI:https://doi.org/10.1007/s00213-017-4675-9 15. Grigsby KB, Kerr NR, Kelty TJ, Mao X, Childs TE, Booth FW. Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats. J Funct Morphol Kinesiol. 2022;8(1):6.DOI:https://doi.org/10.3390/jfmk8010006 16. Yaruskina N, Zenko MY, Morozova OY, Komkova O, Baranova K, Zhuikova S, et al. The influence of social isolation and enriched environment on the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis, pain sensitivity, and behavior in rats after exposure to an ulcerogenic stressor. Rossijskij fiziologičeskij žurnal im IM Sečenova. 2024;110(9):1510–28.DOI:https://doi.org/10.31857/S0869813924090162 17. Lu J, Li X, Wang L, Fan J, Zhang Y, Lu X, et al. Effects of different-intensity swimming exercises on spatial learning and memory ability and the expression of Orexin A in the rat cerebellum. Chinese Journal of Tissue Engineering Research. 2021;25(23):3697.DOI:https://doi.org/10.12307/2021.042 18. Haskell-Luevano C, Schaub JW, Andreasen A, Haskell KR, Moore MC, Koerper LM, et al. Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. FASEB J. 2009;23(2):642–55.DOI:https://doi.org/10.1096/fj.08-109686 19. Niswender KD, Magnuson MA. Obesity and the beta cell: lessons from leptin. J Clin Invest. 2007;117(10):2753–6.DOI:https://doi.org/10.1172/JCI33528 20. Martins PJ, D'Almeida V, Pedrazzoli M, Lin L, Mignot E, Tufik S. Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity. Regul Pept. 2004;117(3):155–8.DOI:https://doi.org/10.1016/j.regpep.2003.10.003 21. Parastesh M, Saremi A. The Effect of Endurance and Resistance Training on Serum Level of Orexin A, Lipid Profiles and Food Intake in Male Rats: An Experimental Study. Journal of Rafsanjan University of Medical Sciences. 2019;17(12):1143–54.DOI:https://dor.isc.ac/dor/20.1001.1.17353165.1397.17.12.7.8 22. Droste SK, Chandramohan Y, Hill LE, Linthorst AC, Reul JM. Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level. Neuroendocrinology. 2007;86(1):26–37.DOI:https://doi.org/10.1159/000104770 23. Control CftPo, Animals SoEo. CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol. 2003;35(4):257–74 24. Huang AM, Jen CJ, Chen HF, Yu L, Kuo YM, Chen HI. Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor. J Neural Transm (Vienna). 2006;113(7):803–11.DOI:https://doi.org/10.1007/s00702-005-0359-4 25. Gomes da Silva S, Unsain N, Masco DH, Toscano-Silva M, de Amorim HA, Silva Araujo BH, et al. Early exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of rats. Hippocampus. 2012;22(2):347–58.DOI:https://doi.org/10.1002/hipo.20903 26. Rostami S, Haghparast A, Fayazmilani R. The downstream effects of forced exercise training and voluntary physical activity in an enriched environment on hippocampal plasticity in preadolescent rats. Brain Res. 2021;1759:147373.DOI:https://doi.org/10.1016/j.brainres.2021.147373 27. Stranahan AM, Khalil D, Gould E. Social isolation delays the positive effects of running on adult neurogenesis. Nat Neurosci. 2006;9(4):526–33.DOI:https://doi.org/10.1038/nn1668 28. Armario A, Ortiz R, Balasch J. Effect of crowding on some physiological and behavioral variables in adult male rats. Physiol Behav. 1984;32(1):35–7.DOI:https://doi.org/10.1016/0031-9384(84)90066-0 29. Ang ET, Dawe GS, Wong PT, Moochhala S, Ng YK. Alterations in spatial learning and memory after forced exercise. Brain Res. 2006;1113(1):186–93.DOI:https://doi.org/10.1016/j.brainres.2006.07.023 30. Zaias J, Queeney TJ, Kelley JB, Zakharova ES, Izenwasser S. Social and physical environmental enrichment differentially affect growth and activity of preadolescent and adolescent male rats. J Am Assoc Lab Anim Sci. 2008;47(2):30–4 31. Gorostegi-Anduaga I, Corres P, MartinezAguirre-Betolaza A, Perez-Asenjo J, Aispuru GR, Fryer SM, et al. Effects of different aerobic exercise programmes with nutritional intervention in sedentary adults with overweight/obesity and hypertension: EXERDIET-HTA study. Eur J Prev Cardiol. 2018;25(4):343–53.DOI:https://doi.org/10.1177/2047487317749956 32. Kotz CM, Teske JA, Billington CJ. Neuroregulation of nonexercise activity thermogenesis and obesity resistance. Am J Physiol Regul Integr Comp Physiol. 2008;294(3):R699–710.DOI:https://doi.org/10.1152/ajpregu.00095.2007 33. Wu MF, Nienhuis R, Maidment N, Lam HA, Siegel JM. Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes. Arch Ital Biol. 2011;149(4):492–8.DOI:https://doi.org/10.4449/aib.v149i4.1315 34. Chieffi S, Messina G, Villano I, Messina A, Esposito M, Monda V, et al. Exercise Influence on Hippocampal Function: Possible Involvement of Orexin-A. Front Physiol. 2017;8:85.DOI:https://doi.org/10.3389/fphys.2017.00085 35. James MH, Campbell EJ, Dayas CV. Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders. Curr Top Behav Neurosci. 2017;33:197–219.DOI:https://doi.org/10.1007/7854_2016_56 36. Chieffi S, Carotenuto M, Monda V, Valenzano A, Villano I, Precenzano F, et al. Orexin System: The Key for a Healthy Life. Front Physiol. 2017;8:357.DOI:https://doi.org/10.3389/fphys.2017.00357 37. Williams RH, Jensen LT, Verkhratsky A, Fugger L, Burdakov D. Control of hypothalamic orexin neurons by acid and CO2. Proc Natl Acad Sci U S A. 2007;104(25):10685–90.DOI:https://doi.org/10.1073/pnas.0702676104 38. Moraska A, Deak T, Spencer RL, Roth D, Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2000;279(4):R1321–9.DOI:https://doi.org/10.1152/ajpregu.2000.279.4.R1321 39. Makatsori A, Duncko R, Schwendt M, Moncek F, Johansson BB, Jezova D. Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats. Psychoneuroendocrinology. 2003;28(5):702–14.DOI:https://doi.org/10.1016/s0306-4530(02)00062-8