1. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-82. https://doi.org/10.1111/epi.12550
2. Pitkänen A, Lukasiuk K. Mechanisms of epileptogenesis and potential treatment targets. Lancet Neurol. 2011;10(2):173-86. https://doi.org/10.1016/S1474-4422(10)70310-0
3. Hollis A, Lukens JR. Role of inflammasomes and neuroinflammation in epilepsy. Immunol Rev. 2025;329(1):e13421. https://doi.org/10.1111/imr.13421
4. Kong H, Yin F, He F, Omran A, Li L, Wu T, et al. The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation. J Mol Neurosci. 2015;57(1):28-37. https://doi.org/10.1007/s12031-015-0574-x
5. Liu H, Roy M, Tian FF. MicroRNA-based therapy: a new dimension in epilepsy treatment. Int J Neurosci. 2013;123(9):617-22. https://doi.org/10.3109/00207454.2013.789513
6. Gan N, Yang L, Omran A, Peng J, Wu L, He F, et al. Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is involved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-κB pathway in astrocytes. Mol Neurobiol. 2014;49(1):337-51. https://doi.org/10.1007/s12035-013-8522-7
7. Zhang S, Chen F, Zhai F, Liang S. Role of HMGB1/TLR4 and IL-1β/IL-1R1 Signaling Pathways in Epilepsy. Front Neurol. 2022;13:904225. https://doi.org/10.3389/fneur.2022.904225
8. Cavalcante BRR, Improta-Caria AC, Melo VH, De Sousa RAL. Exercise-linked consequences on epilepsy. Epilepsy Behav. 2021;121(Pt A):108079. https://doi.org/10.1016/j.yebeh.2021.108079
9. Ribarič S. Physical exercise, a potential non-pharmacological intervention for attenuating neuroinflammation and cognitive decline in Alzheimer’s disease patients. International journal of molecular sciences. 2022;23(6):3245. https://doi.org/10.3390/ijms23063245
10. Häfele CA, Freitas MP, da Silva MC, Rombaldi AJ. Are physical activity levels associated with better health outcomes in people with epilepsy? Epilepsy & Behavior. 2017;72:28-34. https://doi.org/10.1016/j.yebeh.2017.04.038
11. Allendorfer JB, Brokamp GA, Nenert R, Szaflarski JP, Morgan CJ, Tuggle SC, et al. A pilot study of combined endurance and resistance exercise rehabilitation for verbal memory and functional connectivity improvement in epilepsy. Epilepsy & Behavior. 2019;96:44-56. https://doi.org/10.1016/j.yebeh.2019.04.020
12. Feter N, Alt R, Häfele CA, da Silva MC, Rombaldi AJ. Effect of combined physical training on cognitive function in people with epilepsy: results from a randomized controlled trial. Epilepsia. 2020;61(8):1649-58. https://doi.org/10.1111/epi.16588
13. McAuley JW, Long L, Heise J, Kirby T, Buckworth J, Pitt C, et al. A prospective evaluation of the effects of a 12-week outpatient exercise program on clinical and behavioral outcomes in patients with epilepsy. Epilepsy & Behavior. 2001;2(6):592-600. https://doi.org/10.1006/ebeh.2001.0271
14. Shishmanova-Doseva M, Georgieva K, Uzunova Y, Ioanidu L, Atanasova M, Nenchovska Z, Tchekalarova J. Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. Int J Mol Sci. 2022;23(21). https://doi.org/10.3390/ijms232113188
15. de Lima Rosa G, Guzzo EFM, Nunes SEB, Padilha RB, Domingues AM, Barbosa BB, et al. Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. Epilepsy Res. 2022;186:107018. https://doi.org/10.1016/j.eplepsyres.2022.107018
16. Allendorfer JB, Brokamp GA, Nenert R, Szaflarski JP, Morgan CJ, Tuggle SC, et al. A pilot study of combined endurance and resistance exercise rehabilitation for verbal memory and functional connectivity improvement in epilepsy. Epilepsy Behav. 2019;96:44-56. https://doi.org/10.1016/j.yebeh.2019.04.020
17. Tchekalarova J, Shishmanova M, Atanasova D, Stefanova M, Alova L, Lazarov N, Georgieva K. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain Res. 2015;1625:39-53. https://doi.org/10.1016/j.brainres.2015.08.022
18. Gomes da Silva S, de Almeida AA, Silva Araújo BH, Scorza FA, Cavalheiro EA, Arida RM. Early physical exercise and seizure susceptibility later in life. Int J Dev Neurosci. 2011;29(8):861-5. https://doi.org/10.1016/j.ijdevneu.2011.07.011
19. Cerqueira É, Marinho DA, Neiva HP, Lourenço O. Inflammatory effects of high and moderate intensity exercise—a systematic review. Frontiers in physiology. 2020;10:489354. https://doi.org/10.3389/fphys.2019.01550
20. Paolucci EM, Loukov D, Bowdish DM, Heisz JJ. Exercise reduces depression and inflammation but intensity matters. Biological psychology. 2018;133:79-84. https://doi.org/10.1016/j.biopsycho.2018.01.015
21. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972;32(3):281-94. https://doi.org/10.1016/0013-4694(72)90177-0
22. Arida RM, Sanabria ERG, da Silva AC, Faria LC, Scorza FA, Cavalheiro EA. Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy. Physiology & behavior. 2004;83(1):165-71. https://doi.org/10.1016/j.physbeh.2004.08.008
23. Michev A, Orsini A, Santi V, Bassanese F, Veraldi D, Brambilla I, et al. An Overview of The Role of Tumor Necrosis Factor-Alpha in Epileptogenesis and Its Terapeutic Implications. Acta Biomed. 2022;92(S4):e2021418. https://doi.org/ 10.23750/abm.v92iS4.12667
24. Jia Y, Tang L, Yao Y, Zhuo L, Qu D, Chen X, et al. Low-intensity exercise combined with sodium valproate attenuates kainic acid-induced seizures and associated co-morbidities by inhibiting NF-κB signaling in mice. Front Neurol. 2022;13:993405. https://doi.org/10.3389/fneur.2022.993405
25. Gill R, Tsung A, Billiar T. Linking oxidative stress to inflammation: Toll-like receptors. Free Radical Biology and Medicine. 2010;48(9):1121-32. https://doi.org/10.1016/j.freeradbiomed.2010.01.006
26. Zhao T, Zhang X, Cui X, Su S, Li L, Chen Y, et al. Inhibiting the IRAK4/NF-κB/NLRP3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy. Experimental Neurology. 2024;377:114794. https://doi.org/10.1016/j.expneurol.2024.114794
27. Ogunsuyi O, Aro P, Umar H, Oboh G. Administration of curcumin plus treadmill exercise modulate some neuronal enzyme activities, redox markers and BDNF mRNA expression in pilocarpine-induced epileptic seizure in rats. Neurochemical Journal. 2023;17(3):467-76. https://doi.org/10.1134/S1819712423030145
28. Holmes PV, Reiss JI, Murray PS, Dishman RK, Spradley JM. Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats. Behavioural Brain Research. 2015;284:19-23. https://doi.org/10.1016/j.bbr.2015.02.002