نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه خوارزمی، تهران، ایران
2 دانشیار فیزیولوژی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه خوارزمی تهران، تهران، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Abstract
Background and Aim: Obesity and overweight are recognized as major public health concerns in recent years, and their management requires multidimensional approaches. Regular physical activity not only improves body composition but also influences metabolic and inflammatory processes through the secretion of myokines. Among these, Leukemia Inhibitory Factor (LIF) is an exercise-induced myokine that plays a crucial role in glucose uptake, energy metabolism, and the modulation of inflammatory responses. On the other hand, yohimbine, an α₂-adrenergic receptor antagonist, acts as a lipolysis-stimulating supplement that affects metabolic pathways. Accordingly, this study aimed to investigate the effect of concurrent training combined with high and low doses of yohimbine on plasma LIF concentrations in overweight men.
Materials and Methods: In this quasi-experimental study, twenty-four overweight men (age 24 ± 3 years, BMI ≥ 25) were randomly assigned to three groups: concurrent training + high-dose yohimbine (40 mg), concurrent training + low-dose yohimbine (20 mg), and control. The intervention lasted four weeks with three sessions per week, consisting of included compound movement resistance training and high-intensity interval training (HIIT). Supplements were administered in two daily doses. Body composition indices, aerobic fitness, muscle strength, and serum LIF levels were assessed before and after the intervention. Data were analyzed using paired t-tests and analysis of covariance (ANCOVA).
Results: Both experimental groups showed significant reductions in body weight (P < 0.01) and body fat percentage (P < 0.01) compared to the control group. Specifically, the high-dose group experienced a 2.37% reduction in body weight, and the low-dose group a 1.83% reduction, while the control group showed a 0.37% increase. Serum LIF levels increased in both training groups, with the greatest increase observed in the low-dose group, which differed significantly from the high-dose and control groups (P < 0.01). Aerobic fitness and muscle strength also improved significantly in both experimental groups, though no significant differences were detected between the two supplementation doses.
Conclusion: The findings suggest that concurrent training combined with yohimbine supplementation can improve body composition, physical performance, and serum LIF levels in overweight men over a short period. Considering the adverse effects of high-dose yohimbine, such as elevated blood pressure, and the superior effectiveness of the low dose in increasing LIF levels, concurrent training with low-dose yohimbine may represent a safer and more effective strategy for reducing metabolic and inflammatory risk factors in overweight individuals.
Keywords: body composition, myokine, cytokine, aerobic fitness, concurrent training, physical performance
کلیدواژهها [English]
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