نشریه فیزیولوژی ورزش و فعالیت بدنی

نشریه فیزیولوژی ورزش و فعالیت بدنی

تأثیر 12 هفته تمرین تداومی با شدت بالا (HICT) به همراه مصرف کورکومین بر مقادیر سرمی مایونکتین، LECT2، FGF21 و فتوئین A در مردان جوان مبتلا به کبد چرب غیرالکلی

نوع مقاله : مقاله پژوهشی

نویسندگان
گروه فیزیولوژی ورزشی و حرکات اصلاحی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران
چکیده
زمینه و هدف: کبد چرب غیرالکلی (NAFLD) از شایع‌ترین بیماری‌های مزمن کبدی در سطح جهان است که با اختلالات سوخت‌وسازی و التهابی همراه است و خطر پیشرفت به سیروز و کارسینوم هپاتوسلولار را افزایش می‌دهد. مایونکتین، LECT2، FGF21 و فتوئین A به عنوان نشانگرهای زیستی کلیدی در پاتوژنز NAFLD شناخته می‌شوند؛ به طوری که مایونکتین و LECT2 سطوح التهابی را افزایش می‌دهند، FGF21 مقاومت به انسولین را تعدیل می‌کند و فتوئین A در تنظیم سوخت‌وساز چربی نقش دارد. پژوهش حاضر با هدف بررسی اثرات 12 هفته مداخلۀ تمرینی مداوم با شدت بالا (HICT) همراه با مصرف کورکومین بر مقادیر سرمی این نشانگرهای زیستی در مردان مبتلا به NAFLD انجام شد.
مواد و روش‌ها: در این کارآزمایی بالینی تصادفی‌شده و کنترل‌شده با طرح عاملی 2×2، شصت مرد مبتلا به NAFLD در محدودۀ سنی 30 تا 40 سال به صورت تصادفی در چهار گروه 15 نفره قرار گرفتند: 1- تمرین + کورکومین، 2- تمرین تنها، 3- کورکومین تنها و 4- دارونما. پروتکل HICT شامل 30 دقیقه دویدن با شدت 75 تا 90 درصد اکسیژن مصرفی بیشینه (VO2max)، سه جلسه در هفته به مدت 12 هفته بود. مکمل‌دهی کورکومین شامل مصرف روزانه یک کپسول 80 میلی‌گرمی به مدت 12 هفته انجام شد. سطوح سرمی فتوئین A، FGF21، LECT2 و مایونکتین، پیش و پس از مداخله با روش الایزا (ELISA) اندازه‌گیری شد. نیم‌رخ لیپیدی (HDL، LDL، تری‌گلیسیرید و کلسترول تام) نیز در همین دو نقطۀ زمانی بررسی گردید. داده‌ها با استفاده از آزمون تحلیل واریانس‌ دو در دو (ANOVA عاملی) و آزمون t همبسته برای مقایسات درون‌گروهی تحلیل شدند. سطح معناداری در تمام آزمون‌ها، P
کلیدواژه‌ها
موضوعات

عنوان مقاله English

The effect of 12 weeks of high-intensity continuous training (HICT) with curcumin supplementation on serum levels of myonectin, LECT2, FGF21, and fetuin-A in young men with nonalcoholic fatty liver disease

نویسندگان English

Mohamad Ali Zarzoor
Asghar Tofighi
Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran
چکیده English

Background and Purpose: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver disorders worldwide, characterized by metabolic dysregulation and low-grade inflammation, with a substantial risk of progression to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Myonectin and LECT2 are recognized as inflammatory mediators, FGF21 as a regulator of insulin resistance, and fetuin-A as a modulator of lipid metabolism, all playing central roles in NAFLD pathogenesis. The present study investigated the effects of 12 weeks of high-intensity continuous training (HICT) combined with curcumin supplementation on the serum levels of these biomarkers in men diagnosed with NAFLD.
Materials and Methods: This randomized controlled trial employed a 2×2 factorial design. 60 men with NAFLD aged 30-40 years were randomly allocated to four equal groups (n= 15): (1) exercise + curcumin, (2) exercise only, (3) curcumin only, and (4) placebo. The HICT protocol consisted of 30 minutes of treadmill running at 75-90% of maximal oxygen uptake (VO2max), three sessions per week for 12 weeks. Curcumin supplementation involved the daily oral intake of one 80 mg capsule for 12 weeks. Serum levels of fetuin-A, FGF21, LECT2, and myonectin were measured at baseline and post-intervention using enzyme-linked immunosorbent assay (ELISA). Lipid profile markers, including HDL-cholesterol, LDL-cholesterol, triglycerides, and total cholesterol, were assessed at the same time points. Data were analyzed using two-way factorial ANOVA for between-group comparisons and paired-samples t-tests for within-group changes. Statistical significance was set at P

کلیدواژه‌ها English

HICT, NAFLD, Curcumin
FGF21, LECT2, Fetuin-A
Myonectin
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