Background and Objective: To find the effect of new resistance training, including Myostatin, on hypertrophy compared to other traditional exercises, it is better to examine the balance of the two hormones folstatin and myostatin. Since little research has been done on the Myostatin training system in terms of hormones and there are still uncertainties about it compared to the traditional system, therefore, in this regard, the present study aimed to investigate the effect of resistance training using the Myostatin, traditional and their combination methods on hypertrophy and muscle strength, plasma levels of folstatin and myostatin in trained men.
Materials and Methods: 30 men (age: 20-30 years) who had a history of resistance training for at least one year were selected. Participants were randomly divided into three groups (10 people): Myostatin (MT), traditional (TT) and hybrid training group (HT). Resistance training was performed 3 days a week for 10 weeks. The training intensity in all three groups was 75% of one repetition maximum for weeks 1 to 4, 80% of one repetition maximum for weeks 5 to 7, and 85% of one repetition maximum for weeks 8 to 10. Plasma folstatin and myostatin levels, as well as the cross-sectional area of ​​the rectus femoris, vastus lateralis, and biceps brachii muscles, were measured by ultrasound. Maximum strength of the chest and leg muscles was also evaluated. Data were analyzed with SPSS27 software at a significance level of P<0.05. Graphs were drawn with GraphPadPrism10 software.
Results: A significant decrease in folstatin (P=0.033) in the MT group at the post-test compared to the pre-test and a significant increase in folstatin; was observed in the HT (P=0.027) and TT (P=0.005) groups compared to MT. In the variable of biceps cross-sectional area, a significant increase was seen in the HT group compared to MT (P=0.025) and in the variable of rectus femoris cross-sectional area, a significant increase was seen in the combined group compared to TT (P=0.036). A significant increase in chest muscle strength was observed in the MT group compared to TT (P=0.002). After examining the pre-post test times in each group; a significant increase in the cross-sectional area of ​​biceps and rectus femoris, leg and chest strength was observed (P=0.001).
Conclusion:. Due to the high training load, Myorps can be used in shorter training periods (less than 10 weeks), and if this type of training system is used in long training periods such as 10 weeks, it should be combined with a traditional training system to bring desirable results for the athlete.