تاثیر یک دوره تمرین قدرتی بر غلظت کمرین سرم و مقاومت انسولینی در مردان جوان چاق غیرفعال

نوع مقاله : علمی - پژوهشی

نویسندگان

دانشگاه آزاد اسلامی

چکیده

هدف: هدف از مطالعه حاضر بررسی تاثیر یک دوره تمرین قدرتی بر غلظت کمرین سرم و مقاومت انسولینی در مردان جوان چاق غیرفعال بود. روش‌ شناسی: در یک کارآزمایی نیمه‌تجربی، 21 مرد جوان چاق غیرفعال بطور تصادفی به دو گروه تمرین قدرتی (10 نفر، 3/3 ± 7/26 سال، 5/5 ± 1/96 کیلوگرم، 9/2 ± 2/31 درصد چربی، 8/2 ± 6/32 کیلوگرم بر متر مربع) و کنترل (11 نفر، 7/3 ± 1/28 سال، 7/5 ± 7/95 کیلوگرم، 2/3 ± 9/30 درصد چربی، 7/3 ± 1/32 کیلوگرم بر متر مربع) تقسیم شدند. وزن، درصد چربی، نمایه توده بدن، سطوح در گردش کمرین، انسولین و گلوکز و شاخص مقاومت انسولینی (HOMA-IR) قبل و پس از دوره تمرین اندازه‌گیری شد. پروتکل تمرین قدرتی شامل دوازده هفته تمرین با وزنه بود. تجزیه و تحلیل داده‌ها با بکارگیری نرم‌افزار آماری SPSS-16 و با استفاده از آزمون‌های t همبسته و مستقل و ضریب همبستگی پیرسون صورت گرفت. نتایج: تمرین قدرتی غلظت سرمی کمرین (011/0=P) و انسولین (013/0=P) و HOMA-IR (007/0=P) را بطور معنی‌داری کاهش داد، اما غلظت گلوکز سرم تغییر معنی‌داری نیافت. همچنین، تغییرات غلظت کمرین سرم متعاقب تمرین با تغییرات غلظت انسولین سرم (012/0=P، 51/0=r) و HOMA-IR (027/0=P، 52/0=r) همبستگی مستقیم داشت، اما همبستگی معنی‌داری با تغییرات غلظت گلوکز سرم نشان نداد. بحث و نتیجه‌گیری: به نظر می‌رسد تمرین قدرتی از طریق کاهش سطوح کمرین و انسولین سرم و مقاومت انسولینی می‌تواند خطر ابتلا به بیماری‌های قلبی-عروقی و متابولیکی را در مردان جوان چاق غیرفعال کاهش دهد. بر اساس یافته‌های مطالعه حاضر، تغییرات سطوح کمرین سرم متعاقب دوره تمرین قدرتی با تغییرات سطوح انسولین سرم و مقاومت انسولینی همبستگی مستقیم دارد.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of a period of strength training on serum chemerin concentration and insulin resistance in inactive young obese men

چکیده [English]



Purpose: The purpose of present study was to survey effect of a period of strength training on serum chemerin concentration and insulin resistance in inactive young obese men. Materials & Methods: In a semi- experimental study, twenty one inactive young obese men were randomly placed at two groups: strength training (n=10, 26.7 ± 3.3 yr, 96.15.5 kg, 31.22.9%, 32.6 2.8 kg/m2) and control (n=11, 28.1 ± 3.7 yr, 95.75.7 kg, 30.9 3.2 %, 32.1 ± 3.7 kg/m3). Weight, fat percent, body mass index, circulating levels of chemerin, insulin, and glucose, and insulin resistance index (HOMA-IR) were assessed before and after the training. Strength training protocol consisted of twelve weeks weight training. Data were analyzed by SPSS16 software and using Independent and Paired t-tests and Pearson's correlation analysis. Results: Strength training significantly decreased serum concentrations of chemerin (P-0.011), insulin (P-0.013) and HOMA- IR (P=0.007), while scrum glucose concentration didn't change significantly. Also, changes of serum chemerin concentration following the training was directly correlated to changes of serum insulin concentration (r-0.51, p=0.012) and HOMA-IR (r=0.52, p=0.027), while didn't show significant correlation with serum glucose concentration. Conclusion: It appears that, via decrease of circulating levels of chemerin and insulin and insulin resistance, strength training can reduce the risk of cardiovascular and metabolic diseases in inactive young obese men. According to findings of the study, changes of serum chemerin levels following strength training has direct correlations with changes of serum levels of insulin and insulin resistance.

کلیدواژه‌ها [English]

  • Strength Training
  • Chemerin
  • Insulin
  • Insulin Resistance
  • Obese

مراجع

  1. منابع
  2. Tanti JF, Ceppo F, Jager J, Berthou F. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne) 2012; 3:181.
  3. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006; 7:85–96.
  4. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29:415–45.
  5. Lolmede K, Duffaut C, Zakaroff-Girard A, Bouloumie A. Immune cells in adipose tissue: key players in metabolic disorders. Diabetes Metab 2011; 37:283–90.
  6. Bertola A, Ciucci T, Rousseau D, Bourlier V, Duffaut C, Bonnafous S, et al. Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes 2012; 61:2238–47.
  7. Sun S, Ji Y, Kersten S, Qi L. Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr 2012; 32:261–86.
  8. Regazzetti C, Peraldi P, Gremeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 2009; 58:95–103.
  9. Wood IS, de Heredia FP, Wang B, Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc 2009; 68:370–377.
  10. Cianflone K, Lu H, Smith J, Yu W, and Wang H. Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children. Clin Endocrinol 2005; 62:567–72.
  11. Wellen KE, and Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Investig 2005; 115:1111–9.
  12. Zabel BA, Zuniga L, Ohyama T, Allen SJ, Cichy J, Handel TM, et al. Chemoattractants, extracellular proteases, and the integrated host defense response. Exp Hematol 2006; 34:1021–32.
  13. Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, et al. Chemerin activation by serine proteases of the coagu- lation, fibrinolytic and inflammatory cascades. J Biol Chem 2005; 280:34661–6.
  14. Zabel BA, Silverio AM, and Butcher EC. Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J Immunol 2005; 174:244–51.
  15. Wittamer V, Bondue B, Guillabert A, Vassart G, Parmentier M, and Communi D. Neutrophil-mediated maturation of chemerin : a link between innate and adaptive immunity. J Immunol 2005; 175:487–93.
  16. Goralski KB, Acott PD, Fraser AD, Worth D, and Sinal CJ. Brain cyclosporin A levels are determined by ontogenic regulation of mdr1a expression. Drug Metab Dispos 2006; 34:288–95.
  17. Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, et al. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 2007; 148:4687–94.
  18. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007; 282(38):28175-88.
  19. Ouwens DM, Bekaert M, Lapauw B, Van Nieuwenhove Y, Lehr S, Hartwig S, et al. Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome. Arch Physiol Biochem 2012; 118(3):135-8.
  20. Yang M, Yang G, Dong J, Liu Y, Zong H, Liu H, Boden G, Li L. Elevated plasma levels of chemerin in newly diagnosed type 2 diabetes mellitus with hypertension. J Investig Med 2010; 58(7):883-6.
  21. Chakaroun R, Raschpichler M, Klöting N, Oberbach A, Flehmig G, Kern M, et al. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism 2012; 61(5):706-14.
  22. Venojärvi M, Wasenius N, Manderoos S, Heinonen OJ, Hernelahti M, Lindholm H, et al. Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation. Ann Med 2013; 45(2):162-70.
  23. Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-Week Aerobic Training Decreases Chemerin Level and Improves Cardiometabolic Risk Factors in Overweight and Obese Men. Asian J Sports Med 2010; 1(3):151–8.
  24. Ford E. Does exercise reduce inflammation? Physical activity and C-reactive protein among U. S. adults. Epidemiology 2002; 13:561–8.
  25. Matinhomaee H, Moradi F, Azarbayjani MA, Peeri M. Growth Hormone, Insulin Resistance Index, Lipid Profile, and Cardiorespiratory Function in Obese and Lean Inactive Young Men: Correlations with Plasma Acylated Ghrelin Levels. Knowledge & Health 2011; 6(2):18-25.
  26. English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JP. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 2002; 87(6):2984-7.
  27. Goral M. Effects of leptin, diet and various exercises on the obesity. Research Journal of Biological Sciences 2008; 3(11): 1356-64.
  28. Maud PJ, Foster C. Physiological assessment of human fitness. Human Kinetics 2006; 2nd ed. pp: 185-190.
  29. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr 1978; 40 497-504.
  30. Siri WE 1993. Body composition from fluid spaces and density: analysis of methods. 1961. Nutrition 1993; 9:480-91.
  31. American College of Sports Medicine. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2009; 41(3):687-708.
  32. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. Eur J Endocrinol 2007; 157: 625-31.
  33. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-9.
  34. Maddah M, Jazayery A, Mirdamadi R, Eshraghiyan MR, Jalali M. Sex hormones, leptin and anthropometric indices in men. J Reprod Infertil 2001; 2(2):4-13. [Persian]
  35. Rahmani-nia F, Rahnama N, Hojjati Z, Soltani B. Acute effects of aerobic and resistance exercises on serum leptin and risk factors for coronary heart disease in obese females. Sport Sci Health 2008; 2(3):118-24.
  36. Alfadda AA, Sallam RM, Chishti MA, Moustafa AS, Fatma S, Alomaim WS, et al. Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: Adipose depot specificity and gender dimorphism. Mol Cells 2012; 33(6):591-6.
  37. DeFronzo RA, Sherwin RS, Kraemer N. Effect of physical training on insulin action in obesity. Diabetes. 1987; 36:1379–85.
  38. Henriksson J. Influence of exercise on insulin sensitivity. J Cardiovasc Risk 1995; 2:303–9.
  39. Buemann B, Tremblay A. Effects of exercise training on abdominal obesity and related metabolic complications. Sports Med 1996; 21:191–212.
  40. Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 1996; 335:1357–62.
  41. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. American College of Sports Medicine; American Diabetes Association. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010; 33:e147–e167.
  42. Davidson L, Hudson R, Kilpatrick K, Kuk J, McMillan K, Janiszewski P, et al. Effects of exercise modality on insulin resistance and functional limitation in older adults. Arch Intern Med 2009; 169:122–31.
  43. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab 2011; 301(5):E1033–E1039.
  44. Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA. Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. J Clin Endocrinol Metab 2000; 85:2463–8.
  45. Suh S, Jeong I, Kim MY, Kim YS, Shin S, Kim SS, et al. Effects of resistance training and aerobic exercise on insulin sensitivity in overweight Korean adolescents: a controlled randomized trial. Diabetes Metab J 2011; 35(4):418–26.
  46. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil 2005; 86:1527–1533.
  47. Holloszy JO, Narahara HT. Studies of tissue permeability. X. Changes in permeability to 3-methylglucose associated with contraction of isolated frog muscle. J Biol Chem 1965; 240:3493–3500.
  48. Winett RA, Carpinelli RN. Potential health-related benefits of resistance training. Prev Med 2001; 33:503–13.
  49. Chu SH, Lee MK, Ahn KY, Im J-A, Park MS, Lee D-C, et al. Chemerin and adiponectin contribute reciprocally to metabolic syndrome. PloS ONE 2012; 7(4):E34710.
  50. Shin HY, Lee DC, Chu SH, Jeon JY, Lee MK, Im JA, Lee JW. Chemerin levels are positively correlated with abdominal visceral fat accumulation. Clin Endocrinol (Oxf) 2012; 77(1):47-50.
  51. Yan Q, Zhang Y, Hong J, Gu W, Dai M, Shi J, et al. The association of serum chemerin level with risk of coronary artery disease in Chinese adults. Endocrine. 2012; 41(2):281-8.
  52. Yoo HJ, Choi HY, Ynag SJ, Kim HY, Seo JA, Kim SG, et al. Circulating chemerin level is independently correlated with arterial stiffness. J Atheroscler Thromb 2012; 19:59-68.
  53. Dong B, Ji W, Zhang Y. Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with metabolic syndrome. Intern Med 2011; 50:1093-7.
  54. Lin X, Tang X, Jiang Q, Liu Q, Lin Z, Lin J, et al. Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with type 2 diabetes. Clin Lab 2012; 58(5-6):539-44.
  55. Hah Y, Kim N, Kim M, Kim H, Hur S, Yoon H, et al. Relationship between chemerin levels and cardiometabolic parameters and degree of coronary stenosis in Korean patients with coronary artery disease. Diabetes Metab J 2011; 35:248-54.
  56. Ernst MC, Sinal CJ. Chemerin: at the crossroads of inflammation and obesity. Trends Endocrinol Metab 2010; 21(11):660-7.
  57.  

فایل ها

سابقه مقاله

  • تاریخ دریافت: 27 اردیبهشت 1394
  • تاریخ بازنگری: 29 خرداد 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 اردیبهشت 1392

هم رسانی

ارجاع به این مقاله

آمار