تاثیر هشت هفته تمرین ترکیبی بر نسبت هورمون رشد به عامل رشد شبه انسولین یک سرم زنان سالمند

نوع مقاله : علمی - پژوهشی

نویسندگان

داﻧﺸﮕﺎه ﺷﻬﺮﮐﺮد،

چکیده

هدف: امروزه استفاده از الگوهای متفاوت تمرین بویژه تمرینات ترکیبی در بین سالمندان متداول است. تاثیر تمرینات ورزش ترکیبی بر سطوح هورمون ها و عوامل رشدی سالمندان مورد بررسی چندانی قرار نگرفته است. هدف تحقیق حاضر تاثیر 8 هفته تمرین ترکیبی بر سطوح هورمون رشد، IGF-1 و نسبت GH به IGF-1 سرمی زنان سالمند بود. روش تحقیق: در این تحقیق نیمه تجربی با طرح پیش آزمون و پس آزمون، تعداد 21 نفر از زنان سالمند 70- 55 سال انتخاب و بطور تصادفی ساده در دو گروه تمرین ترکیبی (12n=) و کنترل (9n=) تقسیم شدند. برنامه­ تمرینی به مدت 8 هفته و 3 روز در هفته انجام شد. از آزمون تی وابسته جهت تغییرات درون گروهی و از آزمون تی مستقل جهت بررسی اختلاف بین دو گروه استفاده شد. نتایج: نتایج این تحقیق نشان داد مقدار GH، IGF-1 و نسبت GH/IGF-1 پس از تمرین ترکیبی تغییر معنی­داری نیافت (05/0 ≤p ). وزن (005/0=p)، شاخص توده بدنی (005/0=p) و درصد چربی بدن (001/0=)p، پس از 8 هفته تمرین ترکیبی کاهش معنی­داری یافت. افزایش معنی­داری در میزان VO2max مشاهده شد (024/0=p ).  نتیجه‌گیری: در این تحقیق به واسطه انجام 8 هفته تمرین ترکیبی نسبت GH/IGF-1 اندکی افزایش داشت، هرچند معنی­دار نبود. ممکن است انجام این تمرین در طولانی مدت منجر به تغییر GH و IGF-1 گردد. با توجه به بهبود ترکیب بدنی  و توان هوازی، ممکن است انجام این تمرین در طولانی مدت بر نحوه عملکرد دستگاه قلبی عروقی اثر مفیدی داشته باشد و از بروز بیماری آتروسکلروزیس جلوگیری نماید.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of 8 Weeks Combined Training on The Ratio of Growth hormone to Insulin-like growth factor1 of Elderly Women

چکیده [English]



Purpose: The use of different models of training, especially combined training exercises are common
among the elderly. The effect of combined training exercises on hormones and growth factors levels have
been little studied in aging. The purpose of this study was to investigate the effect of 8 weeks concurrent
training on growth hormone, IGF-1 serum concentration and GH/IGF-1 ratio in elderly women.Methods:
In this quasi-experimental study with pre test and post test design, twenty-one healthy elderly women (55-
70 years) were randomly placed into two groups, concurrent training (n=12) and control (n=9) groups.
Training program was done eight weeks, 3 times per week. In order to compare data within and between
groups, dependent t-test and independent t-test was used respectively. Results: The data showed GH,
IGF-1 and GH/IGF-1 ratio were not significantly changed (P≥0.05) following combined training. Also, a
significant decrease observed in body mass(P=0.005), BMI(P=0.005) and body fat percentage (P=0.001)
following 8 weeks combined training (P≤0.05) . VO2max increase significantly (P = 0.024) Conclusion:
In this study, 8 weeks of combined training led to non-significant increase in GH/IGF-1. Maybe, this
training in long-term leads to changes in GH and IGF-1. Therefore, Due to improvements in body
composition and aerobic power, maybe performing the long-term training program have a beneficial
effect on the performance of the cardiovascular system and can be prevented from developing
atherosclerosis.

کلیدواژه‌ها [English]

  • GH
  • IGF-1
  • GH/IGF-1 and combined training

مراجع

  1. Iran. (2011). Statistical Center of Iran. the detailed results of general population and Housing Census. Tehran: Statistical Center of Iran.
  2. Li Q, Wu S, Li S-Y, Lopez FL, Du M, Kajstura J, et al. (2007). Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage. American Journal of Physiology-Heart and Circulatory Physiology. 292(3):H1398-H403.
  3. Kaplan RC, Strickler HD, Rohan TE, Muzumdar R, Brown DL. (2005). Insulin-like growth factors and coronary heart disease. Cardiology in review. 13(1):35-9.
  4. Andreassen M, Raymond I, Kistorp C, Hildebrandt P, Faber J, Kristensen L. (2009). IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population. European Journal of Endocrinology. 160(1):25-31.
  5. Chesik D, Wilczak N, De Keyser J. (2008). IGF-1 regulates cAMP levels in astrocytes through a β2-adrenergic receptor-dependant mechanism. International journal of medical sciences. 5(5):240.
  6. Khan AS, Sane DC, Wannenburg T, Sonntag WE. (2002). Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovascular research. 54(1):25-35.
  7. Gibney J, Healy M-L, Sönksen PH. (2007). The growth hormone/insulin-like growth factor-I axis in exercise and sport. Endocrine reviews. 28(6):603-624.
  8. Chisalita SI, Dahlström U, Arnqvist HJ, Alehagen U. (2011). Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors. European Journal of Endocrinology. 165(6):891-898.
  9. Mangkala J, Buranasukajorn P, Sunthornyothin S, Suwanwalaikorn S, Weerapan Khovidhunkit M, Sridama V, et al. (2008). Normal Reference Range of Serum Insulin-Like Growth Factor (IGF)-I in Healthy Thai Adults. J Med Assoc Thai. 91(11):1681-1684.
  10. Sukhanov S, Higashi Y, Shai S-Y, Vaughn C, Mohler J, Li Y, et al. (2007). IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 27(12):2684-2690.
  11. Hoffman J. (2014). Physiological aspects of sport training and performance: Human Kinetics. 195-207.
  12. Seo D-I, Jun T-W, Park K-S, Chang H, So W-Y, Song W. (2010). 12 weeks of combined exercise is better than aerobic exercise for increasing growth hormone in middle-aged women. International journal of sport nutrition. 20(1):21.
  13. Coffey VG, Jemiolo B, Edge J, Garnham AP, Trappe SW, Hawley JA. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 290(5): 849-856.
  14. Tofighi A, Dehkordi AJ, Tartibian B, Shourabeh FF, Sinaei M. (2012). Effects of Aerobic, Resistance, and Concurrent Training on Secretion of Growth Hormone and Insulin-Like Growth Factor-1 in Elderly Women. Journal of Isfahan Medical School. 30(184) [In persian].
  15. Copeland JL, Consitt LA, Tremblay MS. (2002). Hormonal responses to endurance and resistance exercise in females aged 19–69 years. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 57(4):B158-B65.
  16. Wieczorek-Baranowska A, Nowak A, Michalak E, Karolkiewicz J, Pospieszna B, Rutkowski R, et al. (2011). Effect of aerobic exercise on insulin, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in overweight and obese postmenopausal women. J Sports Med Phys Fitness. 51(3):525-32.
  17. Copeland JL, Chu SY, Tremblay MS. (2004). Aging, physical activity, and hormones in women-a review. Journal of aging and physical activity. 12(1):101-116.
  18. Coburn JW, Malek MH. (2012). NSCA's essentials of personal training: Human Kinetics.
  19. TANG Q-H, XIE X-R. (2008). Research of the Physical Function and Fitness of Elder Intellectuals by Health Qigong· BaDuanJin [J]. Journal of Physical Education Institute of Shanxi Teachers University. 1(6):043.
  20. Cadore E, Pinto R, Lhullier F, Correa C, Alberton C, Pinto S, et al. (2010). Physiological effects of concurrent training in elderly men. International journal of sports medicine. 31(10):689.
  21. Parkhouse WS, Coupland DC, Li C, Vanderhoek KJ. (2000). IGF-1 bioavailability is increased by resistance training in older women with low bone mineral density. Mechanisms of ageing and development. 113(2):75-83.
  22. Nishida Y, Matsubara T, Tobina T, Shindo M, Tokuyama K, Tanaka K, et al. (2010). Effect of low-intensity aerobic exercise on insulin-like growth factor-I and insulin-like growth factor-binding proteins in healthy men. International journal of endocrinology. 10(11): 1-8.
  23. Vitiello MV, Wilkinson CW, Merriam GR, Moe KE, Prinz PN, Ralph DD, et al. (1997). Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 52(3):M149-M54.
  24. Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, et al. (2011). Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocrine-related cancer. 18(3):357-369.
  25. Orsatti FL, Nahas EA, Maesta N, Nahas-Neto J, Burini RC. (2008). Plasma hormones, muscle mass and strength in resistance-trained postmenopausal women. Maturitas. 59(4):394-404.
  26. Nindl BC, Pierce JR. (2010). Insulin-like growth factor I as a biomarker of health, fitness, and training status. Med Sci Sports Exerc. 42(1):39-49.
  27. Eliakim A, Nemet D. (2013). Exercise and the GH–IGF-I Axis. Endocrinology of Physical Activity and Sport: Springer. p. 69-83.
  28. Büyükyazi G, Karamizrak SO, Islegen C. (2003). Effects of continuous and interval running training on serum growth and cortisol hormones in junior male basketball players. Acta Physiologica Hungarica. 90(1):69-79.
  29. Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR. (2003). Effects of Exercise Training on Fasting Insulin, Insulin Resistance, Insulin-like Growth Factors, and Insulin-like Growth Factor Binding Proteins in Postmenopausal Breast Cancer Survivors A Randomized Controlled Trial. Cancer Epidemiology Biomarkers & Prevention. 12(8):721-7.
  30. Viru A. (1992). Plasma hormones and physical exercise. International journal of sports medicine. 13(03):201-209.
  31. Astorino TA, Allen RP, Roberson DW, Jurancich M. (2012). Effect of high-intensity interval training on cardiovascular function, VO2max, and muscular force. Journal of strength and conditioning research / National Strength & Conditioning Association. 26(1):138-45.

فایل ها

سابقه مقاله

  • تاریخ دریافت: 30 خرداد 1395
  • تاریخ بازنگری: 22 خرداد 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 آذر 1394

هم رسانی

ارجاع به این مقاله

آمار