نوع مقاله : علمی - پژوهشی
نویسندگان
چکیده
کلیدواژهها
عنوان مقاله [English]
Purpose: SIRT3 is a member of the sirtuin family of protein deacetylases that is localized in mitochondria
and regulates mitochondrial function. The aim of this study was to investigate the effect of eight-week
aerobic continuous and high intensity interval training on levels of SIRT3 in Wistar rat’s skeletal muscle
tissue. Methods: 24 Wistar rats were randomly divided into four groups of six animals each, namely: 1)
Obese- High-intensity interval training (HIIT), 2) Obese- Continues training (CT) 3) Obese control (OB) and
4) Non-Obese control (Cont.). During the study, groups of rat 1, 2 and 3 were given a high-fat diet. After
familiarization, CT and HIIT rats performed aerobic continuous training and high intensity interval training
three times a week for eight weeks, respectively. 48 hours after the last training session, the rats were
sacrificed. Results: Western blot analysis showed that the amount of SIRT3 protein of Soleus muscle in HIIT
and CT groups was higher than OB and Cont. groups significantly (p< 0.05). Also, SIRT3 content was higher
in HIIT than CT group, though insignificant. Also, no significant difference was observed between SIRT3
content of OB and Cont. However, SIRT3 content was lower in OB group. Conclusion: It seems that using
HIIT exercise can be as effective as continuous training on muscle mitochondrial function and ultimately
contribute to longevity, especially in obese patients and raises important factors such as SIRT3.
کلیدواژهها [English]