مقاسه سه شیوه تمرین ورزشی بر غلظت پروتئین واکنش‌دهندهC و گلبول‌های سفید خونی در بیماران دیابتی نوع2

نوع مقاله : علمی - پژوهشی

نویسنده

دانشگاه بوعلی سینا همدان، دانشکده تربیت بدنی و علوم ورزشی

چکیده

زمینه و هدف: دیابت از جمله بیماری­هایی است که باعث کاهش عملکرد سیستم دفاعی بدن در برابر عفونت­ها می­شود. از گونه میانجی­های التهابی که به­دنبال فعل­و­انفعالات التهاب در کنار گلبول­های سفید ترشح می­شود، پروتئین واکنش­دهنده(CRP) C است، که نشانگر حساسی برای التهاب سیستمیک محسوب می­شود. تمرین منظم با کنترل سوخت ­و­ ساز در دیابتی­ها باعث کنترل قند خون می­شود و به­دنبال آن پاسخ دفاعی بدن را افزایش می­دهد. به­همین منظور این مطالعه به­مقایسه اثر سه شیوه تمرین ورزشی بر CRPو گلبول­های سفید در بیماران دیابتی نوع II  طراحی شده است.مواد وروش ها: در این پژوهش، 52 بیمار مرد دیابتی نوعII (65-40 سال) بطور تصادفی به 4 گروه تمرینی هوازی، مقاومتی، ترکیبی و کنترل تقسیم شدند. در هر گروه 13 نفر قرار گرفت. تمرینات سه جلسه در هفته، هر جلسه 60 دقیقه بمدت 10هفته بطول انجامید. hs-CRP  به روش الایزا و شمارش عناصر WBC در ابتدا و پایان مطالعه اندازه­گیری شد. یافته­ها: یافته­ها تحقیق نشان داد که تمرینات هوازی بطور معنی­داری باعث کاهشhs-CRP و افزایش مونوسیت­ها شد. همچنین تمرینات ترکیبی نیز باعث کاهش سطح CRP و نوتروفیل­ها و افزایش مونوسیت­ها و لنفوسیت­ها شد. کاهش CRP در گروه ترکیبی نسبت به گروه هوازی بتنهایی بارزتر بود ولی در عناصرWBC تفاوتی نداشت.نتیجه گیری: براساس یافته­های پژوهش تجویز تمرینات ورزشی هوازی و بویژه ترکیبی می­تواند روش مناسب برای جلوگیری از بروز عوارض دیابت نوع IIباشد.

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of three exercise training method on plasma CRP levels and WBC in patients with type II diabetes

چکیده [English]

Background: Diabetes is a disease that affects the immune system and causes a decrease in the immune function of body against infections. Among the inflammatory mediators that are secreted that following interaction inflammation with WBC, is CRP, which is a sensitive marker for systemic inflammation. Regular exercise with controlling the glucose metabolism in diabetes control and subsequently it increases immune response of body. The purpose of this study was to compare three different ways of training on CRP and WBC levels in type 2 diabetic patients.
Materials and Methods: 52 patients with type 2 diabetes (40-65 years old) were randomly divided into four groups: aerobic training, resistance, combined (aerobic and resistance) and control groups and each group consisted of 13 subjects. The exercises were done 3 times a week for 60 minutes each session and lasted for 10 weeks. The WBC counts and high-sensitivity CRP (hs-CRP) at baseline and at the end of the study were measured by ELISA.
Results: The research findings showed significant reduction in hs-CRP and increased MONO, aerobic exercise group and decrease in CRP and NEUT levels and increase in MONO and LYM were seen in the combination group. CRP in the combination group was significantly higher than aerobic alone, but no difference in WBC groups was noticed.
Conclusion: According to the findings, the research prescribes aerobic exercise training can be a particularly suitable compound to prevent complications of type 2 diabetes.

کلیدواژه‌ها [English]

  • C-reactive protein- white blood cell-exercise training- type 2 diabetes
  1. REFERENCES:
  2. Festa A, D’Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM.)1. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2002; 102(1):42-7
  3. WHO. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Department of Noncommunicable Disease Surveillance. Geneva. WHO;1999.
  4. Russo AF, Dickerson IM. CGRP: A multifunctional neuropeptide. In: Lim R, editor. Handboook of Neurochemistry and Molecular Neurobiology. 3rd. springer-Verlag Berlin Heidelberg; 2006. P 390-426.
  5. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB.Low-grade systemic inflammation in overweight children. Pediatrics2001; 107:E13.
  6. Peter P. The immune system is body. translator, Niknam, kaghazian M, Tehran, vafagh 1384, vol 1 (Persian)
  7. Saad MJA, Maciel RMB, Mendonça BB. Endocrinologia. Slo Paulo: Atheneu.2007
  8. McLaughlin, T., FahimLamendola, CindyLiang, LynnReaven, GeraldSchaaf, PatriciaReaven, Peter. "Differentiation between obesity and insulin resistance in the association with C-reactive protein." Circulation 2002.106(23): 2908-2912.
  9. Bots, M. L. L. Lenore J Lindemans, Jan Hoes, Arno W Hofman, Albert Witteman, Jacqueline Koudstaal, Peter J Grobbee, Diederick E . Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam Study. Archives of internal medicine1999. 159(1): 38
  10. Hotamisligil, G. S. S., Narinder S Spiegelman, Bruce M . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993.259(5091): 87-91.
  11. Paffen, E., Hans L Bertina, Rogier M . C-reactive protein does not directly induce tissue factor in human monocytes." Arteriosclerosis, thrombosis, and vascular biology2004. 24(5): 975-981.
  12. Dandona, P., AhmadBandyopadhyay, Arindam . Inflammation: the link between insulin resistance, obesity and diabetes. Trends in immunology2004. 25(1): 4-7.
  13. King, D. E., Arch GBuchanan, Thomas APearson, William S . C-reactive protein and glycemic control in adults with diabetes. Diabetes Care2003. 26(5): 1535-1539.
  14. Kasapis C, Thompson P. The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers: A Systematic Review. Journal of the American College of Cardiology 2005; 45(10):1563-9.
  15. Frydelund-Larsen L, Akerstrom T, Nielsen S, Keller P, Keller C, Pedersen BK. VisfatinmRNA expression in human subcutaneous adipose tissue is regulated by exercise. Am J Physiol Endocrinol Metab 2007; 292(1): E24-31.
  16. Ellinger, V., Carlini, L. T., Moreira, R. O., & Meirelles, R. M. Relation between insulin resistance and hematological parameters in a Brazilian sample. Arquivos Brasileiros de Endocrinologia & Metabologia 2006, 50(1), 114-117.
  17. Harrison T, Cecil, Lafayette R. Hematology and Oncology, translation: khodaamorzide D, Tehran , lofty thoughts.1388 (Persian)
  18. Nyström T. C-reactive protein: a marker or a player? Clin Sci (Lond) 2007; 113(2):79-81.
  19. Balducci, S., SNicolucci, AFernando, FCavallo, SCardelli, PFallucca, SAlessi, ELetizia, CJimenez, A . "Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss." Nutrition, Metabolism and Cardiovascular Diseases 2010. 20(8): 608-617.
  20. Jorge, M. L. M. P., de Oliveira, V. N., Resende, N. M., Paraiso, L. F., Calixto, A., Diniz, A. L. D., . & Geloneze, B.. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011, 60(9), 1244-1252.
  21. zamani M. Effect of 8 week aerobic exercise on hematological parameters dependent on morphine withdrawal syndrome. MA thesis Faculty of Literature and Human Sciences, Bu-Ali Sina University1391 (Persian)
  22. Nikseresht, A., Sh, F. H., Solhjoo, K., & Kargar Jahromy, H.. Effect of maximum activity on the immune system cells in diabetic rats. Journal of Jahrom University of Medical Sciences 2013, 10(4), 43.
  23. Çakamakci, E., Sanioglu, A., Vatansev, H., & Marakoglu, K. The effects of 8-week step-aerobic exercise on the body composition and hematologlic parameters in the obese and overweight females. Sci Mov Health 2010, 10, 808-813.
  24. Mel nikov AA, Kylosov AA, Vikulov AD. Relationships of Inflammatory Activitywith biochemical parameters of the blood and sympathovagal balance of young athletes.Human Physiology 2007,vol.33,No.5. PP624-631.
  25. Shin .Y, Keun Oh. J, Sik Sohn. H, Sang Bae. J ,Young Lee. M , Beom Lee J, Mo Yang .H,Ki Min .Y, Yeon Song H, Kyune Ko .K , Matsumot.T Expression of exercise-induced HSP70 in long-distance runner’s leukocytes, Journal of Thermal Biology 2004, 29:769–774.
  26. Bhatti R, Shaikh D,The effect of exercise on blood parameters, Pak J Physiology 2007 ;3(2).
  27. Bobeuf, F., Labonte, M., Khalil, A., & Dionne, I. J. Effect of resistance training on hematological blood markers in older men and women: a pilot study. Current gerontology and geriatrics research, 2009
  28. Karanysh M, Islami S, Marandi S, zandmoghadam A and Hqyqyzadh M., Effect of protein whey supplementation on blood parameters in healthy young Drvrzshkaran resistance activities. Journal of Endocrinology. Shaheed Beheshti University of Medical Sciences 1387(period I, No. Y4, page-Hay379 373)( Persian)
  29. Arazi H, Damirchi A, Mostafalu, Ardabil. Changes in haematological parameters after repeated sessions of resistance training and endurance simultaneously. University Journal of Medical Sciences 1390. Volume 9, Volume 2 ( Persian)
  30. Abul Abbas, Laytmn A, Play S , Translator Mohamdnya M, amozegar A Cellular and molecular immunology ,Tehran: the next generation 1391 (Persian)
  31. Alba-Loureiro, T., Hirabara, S., Mendonca, J., Curi, R., & Pithon-Curi, T. Diabetes causes marked changes in function and metabolism of rat neutrophils. Journal of endocrinology 2006, 188(2), 295-3
  • تاریخ دریافت: 06 شهریور 1394
  • تاریخ بازنگری: 31 اردیبهشت 1403
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 خرداد 1395