نوع مقاله : علمی - پژوهشی

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی،دانشگاه شهید چمران اهواز، اهواز، ایران

3 پزشک متخصص داخلی، (MD)، ماهشهر، ایران

چکیده

هدف: بیماری کبد چرب غیر الکلی (NAFLD) به شدت با تغییر سطح سایتوکاین‌های التهابی و افزایش ناهنجاری‌های متابولیکی همراه است. در این مطالعه اثر تمرین ترکیبی بر غلظت سرمی سایتوکاین‌های پیش التهابی اینترلوکین 18(IL18)، ضد التهابی اینترلوکین 10(IL10) و عوامل مرتبط با اختلال متابولیک در زنان سالمند مبتلا به کبد چرب بررسی شد.
روش­ ها : تعداد 24 زن سالمند مبتلا به NAFLD با روش هدفمند انتخاب و به طور تصادفی به گروه تمرین (n=12) و کنترل (n=12) تقسیم شدند. تمرین ترکیبی به مدت ده هفته اجرا شد. سطوح IL18 و IL10 با بسته آزمایشگاهی زلبایو به روش الایزا و کبد چرب با روش سونوگرافی سنجیده شدند. سایر عوامل خونی و تن سنجی اندازه گیری شدند. تحلیل آماری با آزمون‌های تی زوجی و ویلکاکسون، کواریانس و همبستگی اسپیرمن انجام شد.
نتایج: در گروه تمرین تری گلیسرید (TG) (00/0p=)، شاخص مقاومت به انسولین (HOMA-IR) (01/0p=) ، چربی کبد (00/0p=)، آسپارتات آمینو ترانسفراز (AST) (04/0p=) و گلوکز (00/0p=) به طور قابل توجهی کاهش یافتند. مقدار انسولین (11/0p=) و آلانین آمینو ترانسفراز (ALT) (07/0p=) بین گروه‌ها تفاوت معناداری نداشت.
نتیجه ­گیری: تمرین ترکیبی می تواند باعث بهبود سطح سایتوکاین‌های التهابی و کاهش عوامل خطر متابولیکی مرتبط با کبد چرب غیر الکلی شود و با افزایش اثرات ضد التهابی نقش مؤثری در سلامتی سالمندان ایفا کند.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of combined training on serum concentrations of inflammatory cytokines and factors associated with metabolic syndrome in elderly women with fatty liver

نویسندگان [English]

  • Masoumeh Norouzpour 1
  • Seyed Mohammad Marandi 1
  • Mohsen Ghanbarzadeh 2
  • Abbas Ali Zare Mayavan 3

1 Department of Exercise Physiology, Faculty of Physical Education, University of Isfahan, Isfahan, Iran

2 Department of Sports Physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

3 Internal Medicine (MD), Mahshahr, Iran

چکیده [English]

Purpose: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with altered levels of inflammatory cytokines and increased metabolic abnormalities. In this study, the effect of combined training on serum concentrations of proinflammatory cytokines interleukin 18 (IL18), anti-inflammatory interleukin 10 (IL10) and metabolic syndrome-related factors in elderly women with fatty liver was investigated.
Methods: twenty-four elderly women with NAFLD were selected purposively and were randomly divided into training (n = 12) and control (n = 12) groups. Combined training was performed for ten weeks. Using ZellBio kit, IL18 and IL10 levels were measured by ELISA and fatty liver levels by ultrasound procedure. Blood and anthropometric factors were measured as well. Statistical analysis was performed using paired samples t-test and Wilcoxon, covariance and Spearman correlation procedures.
Results: Decreased and increased serum concentrations of interleukin 18 (P = 0.00) and interleukin 10 (P = 0.00) were observed in the training group compared to the control group, respectively. Also, weight, waist circumference (P = 0.00) and metabolic markers including triglyceride (TG) (P = 0.00), insulin resistance index (HOMA-IR) (P = 0.01), liver fat (P = 0.00), aspartate aminotransferase (AST) (P = 0.04) and glucose (P = 0.00) levels were significantly reduced. Moreover, there was no significant difference between insulin (P = 0.11) and alanine aminotransferase (ALT) (P = 0.07) levels.
Conclusion: Combined training can improve the levels of inflammatory cytokines and reduce metabolic risk factors associated with non-alcoholic fatty liver and play an effective role in the health of the elderly by augmenting anti-inflammatory effects.

کلیدواژه‌ها [English]

  • Hepatic steatosis
  • Combined training
  • Inflammation
  • aging
  • metabolic syndrome
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