نوع مقاله : علمی - پژوهشی
نویسندگان
1 دانشگاه آزاد اسلامی
2 دانشگاه شهید بهشتی
چکیده
چکیدههدف: هدف از این پژوهش بررسی اثر یک دوره تمرین استقامتی بر کلاژن 18 پلاسمایی و عضله قلبی موشهای نر ویستار بود.و تمرین (C) 135 گرم) به طور تصادفی به دو گروه کنترل - 6 هفتهای و 125 - روش شناسی: 16 سر موش صحرایی نر ویستار ( 4تقسیم شدند. برنامه تمرینی شامل 8 هفته، 5 روز در هفته، به مدت 20 تا 60 دقیقه و سرعت 28 تا 34 متر در دقیقه بود. (T)72 ساعت پس از آخرین جلسه تمرینی نمونهگیری خون و بافت برداری انجام شد. مقدار کلاژن 18 به روش الایزا اندازهگیری شد.تجزیه و تحلیل شد. نتایج: مقدار کلاژن 18 پلاسمایی α<0/ مستقل در سطح معنیداری 05 t دادهها با استفاده ازپس از هشت هفته فعالیت (T=40/476±11/933 ،C=20/080±3/ و عضله قلبی ( 169 (T=0/839±0/079 ،C=0/721±0/142)بحث و نتیجهگیری: افزایش کلاژن .( P=0/ ورزشی افزایش داشت، ولی این افزایش فقط در سطح عضله قلبی معنیدار بود ( 04618 احتمالاً نشان دهنده تأثیر فعالیتهای ورزشی بر مهار رگزایی بوده و گواه دیگری بر اثرات ضد سرطانی فعالیتهای ورزشیمیباشد.
کلیدواژه‌ها
- منابع
- - O'Reilly MS, Holmgren L, Shing Y, Chen C,
- Rosenthal RA, Moses M, et al. (1994).
- Angiostatin: a novel angiogenesis inhibitor that
- mediates the suppression of metastases by a
- Lewis lung carcinoma. cell. 79(2):315-28.
- - Hanahan D.( 1996). Patterns and emerging
- mechanisms of the angiogenic switch during
- tumorigenesis. cell.86:353-64.
- - Folkman J, Merler E, Abernathy C, Williams
- G.( 1971). Isolation of a tumor factor
- responsible for angiogenesis. The Journal of
- experimental medicine.133(2):275-88.
- - Richardson R, Wagner H, Mudaliar S, Saucedo
- E, Henry R, Wagner P.( 2000). Exercise
- adaptation attenuates VEGF gene expression in
- human skeletal muscle. American Journal of
- اثر هشت هفته تمرین استقامتی بر کلاژن 18 پلاسمایی و عضله قلبی موشهای صحرایی نر ویستار 700
- Physiology-Heart and Circulatory Physiology
- .279(2):H772-H8.
- - Asano M, Kaneoka K, Nomura T, Asano K,
- Sone H, Tsurumaru K, et al.( 1998). Increase in
- serum vascular endothelial growth factor levels
- during altitude training. Acta physiologica
- scandinavica.162(4):455-60.
- - Gunga HC, Kirsch K, Röcker L, Behn C,
- Koralewski E, Davila EH, et al.( 1999).
- Vascular endothelial growth factor in exercising
- humans under different environmental
- conditions. European journal of applied
- physiology and occupational
- physiology.79(6):484-90.
- - Gustafsson T, Knutsson A, Puntschart A,
- Kaijser L, Nordqvist SAC, Sundberg C ,et al.
- Increased expression of vascular endothelial
- growth factor in human skeletal muscle in
- response to short-term one-legged exercise
- training. Pflügers Archiv European Journal of
- Physiology.444(6):752-9.
- - Saarela J, Rehn M, Oikarinen A, Autio-
- Harmainen H, Pihlajaniemi T.( 2002). The short
- and long forms of type XVIII collagen show
- clear tissue specificities in their expression and
- location in basement membrane zones in
- humans. The American journal of pathology.
- ;153(2):611-26.
- - Sasaki T, Fukai N, Mann K, Göhring W, Olsen
- BR, Timpl R.( 1998). Structure, function and
- tissue forms of the C-terminal globular domain
- of collagen XVIII containing the angiogenesis
- inhibitor endostatin. The EMBO
- journal.17(15):4249-56.
- - O'Reilly MS, Boehm T, Shing Y, Fukai N,
- Vasios G, Lane WS, et al.( 1997). Endostatin:
- an endogenous inhibitor of angiogenesis and
- tumor growth. cell.88(2):277-85.
- - Marneros AG, Olsen BR.( 2005). Physiological
- role of collagen XVIII and endostatin. The
- FASEB Journal.19(7):716-28.
- - Ferreras M, Felbor U, Lenhard T, Olsen BR,
- Delaisse JM.( 2000). Generation and
- degradation of human endostatin proteins by
- various proteinases. FEBS letters.486(3):247-
- - Kovanen V, Suominen H.( 1989). Age-and
- training-related changes in the collagen
- metabolism of rat skeletal muscle. European
- journal of applied physiology and occupational
- physiology.58(7):765-71.
- - Thomas DP, McCormick RJ, Zimmerman SD,
- Vadlamudi RK, Gosselin L.( 1992). Aging-and
- training-induced alterations in collagen
- characteristics of rat left ventricle and papillary
- muscle. American Journal of Physiology-Heart
- and Circulatory Physiology.263(3):H778-H83.
- - Marneros AG.( 2009). Tumor angiogenesis in
- melanoma. Hematology/oncology clinics of
- North America.23(3):431.
- - Kivela R, Silvennoinen M, Lehti M, Jalava S,
- Vihko V, Kainulainen H.( 2008). Exerciseinduced
- expression of angiogenic growth
- factors in skeletal muscle and in capillaries of
- healthy and diabetic mice. Cardiovasc Diabetol.
- (13):10.1186.
- - Deininger MH, Fimmen B, Kremsner PG ,
- Meyermann R, Schluesener HJ.( 2002).
- Accumulation of endostatin/collagenXVIII in
- brains of patients who died with cerebral
- malaria. Journal of
- neuroimmunology.131(1):216-21.
- - Mueller C, Schluesener H, Fauser U, Conrad S,
- Schwab J.( 2007). Lesional expression of the
- endogenous angiogenesis inhibitor
- endostatin/collagen XVIII following traumatic
- brain injury (TBI). Experimental neurology.
- (2):228-37.
- - Castro-Giner F, Bustamante M, Gonzalez JR,
- Kogevinas M, Jarvis D, Heinrich J, et al.(
- . A pooling-based genome-wide analysis
- identifies new potential candidate genes for
- atopy in the European Community Respiratory
- Health Survey (ECRHS). BMC medical
- genetics.10(1):128.
- - Santos S, Oliveira G, Tavares A, Massensini A,
- Carvalhaes L, Reljasvaara R, et al.( 2005).
- Collagen XVIII and fibronectin involvement in
- bullous scleroderma. Dermatology online
- journal.11(1):17.
- - Musso O, Theret N, Heljasvaara R, Rehn M,
- Turlin B, Campion JP, et al.( 2003). Tumor
- hepatocytes and basement membrane–
- Producing cells specifically express two
- different forms of the endostatin precursor,
- collagen XVIII, in human liver cancers.
- Hepatology.33(4):868-76.
- - Hu TH, Huang CC, Wu CL, Lin PR, Liu SY,
- Lin JW, et al.( 2004). Increased
- endostatin/collagen XVIII expression correlates
- with elevated VEGF level and poor prognosis in
- hepatocellular carcinoma. Modern pathology.
- (5):663-72.
- - Passos-Bueno MR, Suzuki OT, Armelin-Correa
- LM, Sertie AL, Errera IV F, Bagatini K, et al.(
- . Mutations in Collagen 18A1 (COL18A1)
- and their relevance to the human phenotype.
- Anais da Academia Brasileira de Ciências.
- (1):123-31.
- - Fathi R, Ghanbari-Niaki A, Rahbarizadeh F,
- Hedayati M, Ghahramanloo E, Farshidi Z.(
- حجت الله نیکبخت و همکاران
- . The effect of exercise on plasma acylated
- ghrelin concentrations and gastrocnemius
- muscle MRNA expression in male rats. Iranian
- Journal of Endocrinology and Metabolism.
- (5):519-26.
- - van Royen N, Piek JJ, Schaper W, Bode C,
- Buschmann I.( 2001). Arteriogenesis:
- mechanisms and modulation of collateral artery
- development. Journal of Nuclear
- Cardiology.8(6):687-93.
- - Risau W.( 1997). Mechanisms of angiogenesis.
- Nature.386(6626):671-4.
- - Muragaki Y, Abe N, Ninomiya Y, Olsen BR,
- Ooshima A.( 1994). The human alpha 1 (XV)
- collagen chain contains a large amino-terminal
- non-triple helical domain with a tandem repeat
- structure and homology to alpha 1 (XVIII)
- collagen. Journal of Biological
- Chemistry.269(6):4042-6.
- - Rehn M, Pihlajaniemi T.( 1994). Alpha 1
- (XVIII), a collagen chain with frequent
- interruptions in the collagenous sequence, a
- distinct tissue distribution, and homology with
- type XV collagen. Proceedings of the National
- Academy of Sciences. 91(10):4234-8.
- - Väänänen A, Ylipalosaari M, Parikka M,
- Kainulainen T, Rehn M, Heljasvaara R, et al.(
- . Collagen XVIII modulation is altered
- during progression of oral dysplasia and
- carcinoma. Journal of oral pathology &
- medicine. 36(1):35-42.
- - Quelard D, Lavergne E, Hendaoui I, Elamaa H,
- Tiirola U, Heljasvaara R, et al.( 2008). A
- Cryptic Frizzled Module in Cell Surface
- Collagen 18 Inhibits Wnt/β −Catenin Signaling.
- PLoS One.3(4):e1878.
- - Sakimoto T, Kim T-i, Ellenberg D, Fukai N,
- Jain S, Azar DT, et al.( 2008). Collagen XVIII
- and corneal reinnervation following
- keratectomy. FEBS letters. 582(25):3674-80.
- - Muragaki Y, Timmons S, Griffith CM, Oh SP,
- Fadel B, Quertermous T, et al.( 1995). Mouse
- Col18a1 is expressed in a tissue-specific manner
- as three alternative variants and is localized in
- basement membrane zones. Proceedings of the
- National Academy of Sciences.92(19):8763-7.
- - Ylikärppä R ,Eklund L, Sormunen R, Kontiola
- AI, Utriainen A, Määttä M, et al.( 2003). Lack
- of type XVIII collagen results in anterior ocular
- defects. The FASEB Journal. 17(15):2257-9.
- - Määttä M, Heljasvaara R, Pihlajaniemi T,
- Uusitalo M.( 2007). Collagen XVIII/endostatin
- shows a ubiquitous distribution in human ocular
- tissues and endostatin-containing fragments
- accumulate in ocular fluid samples. Graefe's
- Archive for Clinical and Experimental
- Ophthalmology. 245(1):74-81.
- - Musso O, Rehn M, Saarela J, Theret N, Lietard
- J, Hintikka E, et al.( 1998). Collagen XVIII is
- localized in sinusoids and basement membrane
- zones and expressed by hepatocytes and
- activated stellate cells in fibrotic human liver.
- Hepatology.28(1):98-107.
- - Beck L, D'Amore PA.( 1997). Vascular
- development: cellular and molecular regulation.
- The FASEB journal.11(5):365-73.
- - Celletti FL, Hilfiker PR, Ghafouri P, Dake
- MD.( 2001). Effect of human recombinant
- vascular endothelial growth factor165 on
- progression of atherosclerotic plaque. Journal of
- the American College of Cardiology.
- (8):2126-30.
- - Hamano Y, Okude T, Shirai R, Sato I, Kimura
- R, Ogawa M, et al.( 2010). Lack of collagen
- XVIII/endostatin exacerbates immune-mediated
- glomerulonephritis. Journal of the American
- Society of Nephrology. 21(9):1445-5.5
- - Lin Y, Zhang S, Rehn M, Itaranta P, Tuukkanen
- J, Heljasvaara R, et al.(2000) Induced
- repatterning of type XVIII collagen expression
- in ureter
)