The Effect of 8 Weeks Resistance Training on Serum BDNF Level and Memory Performance in Middle-aged Women with Metabolic Syndrome

Document Type : original article


Aim: The purpose of this study to verify the effects of resistance training on Serum BDNF Level and Memory Performance in Middle-aged Women with Metabolic Syndrome.
Methods: 22 volunteers middle-age woman with metabolic syndrome for sampling, were selected and randomly assigned to a resistance training protocol (n = 12, 43.08 ± 5.14 years, 74.13 ± 7.16 kg) or a control group (n = 10, 39.9 ± 4.53 years, 82.23 ± 11.61 kg). In the resistance training protocol, ten exercises were performed, with 3 × 8–10 maximal repetitions three times per week With regard to the principle of overload. Short term, midterm and long term memory tests and also blood sampling were conducted before and after training. Data were analyzed using independent and depended t-test, analysis of variance with repeated measures 2 × 2 with the level of statistical significance was set at P ≤ 0.05.
Results: No significant changes in the levels of BDNF and midterm memory in the control and exercise and control groups was not observed (P ≥ 0.05).The dependent t test results showed a significant decrease in short term and long term memory in the exercise group (P ≤ 0.05), but after interactive exercise effect no significant changes was not observed (P ≥ 0.05).
Conclusion: In spite of the fact the BDNF as a metatrophin, mediating the effects of exercise on cognitive function is known, but eight weeks of resistance training cannot have a favorable effect on increasing BDNF and memory function in middle-aged women with metabolic syndrome.


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  • Receive Date: 11 December 2015
  • Revise Date: 25 May 2024
  • Accept Date: 31 December 2020
  • First Publish Date: 31 December 2020
  • Publish Date: 21 November 2016